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CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.
Manfrevola F, Ferraro B, Sellitto C, Rocco D, Fasano S, Pierantoni R, Chianese R. Manfrevola F, et al. Cells. 2021 Jul 31;10(8):1956. doi: 10.3390/cells10081956. Cells. 2021. PMID: 34440724 Free PMC article.
Recently, we have identified differentially expressed circRNAs (DE-circRNAs) in normozoospermic and asthenozoospermic patients, associated with high-quality (A-spermatozoa) and low-quality (B-spermatozoa) sperm. Here, we carried out a differential analysis of CRISP2, CATSPER1 …
Recently, we have identified differentially expressed circRNAs (DE-circRNAs) in normozoospermic and asthenozoospermic patients, associated w …
Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population.
Behvarz M, Rahmani SA, Siasi Torbati E, Danaei Mehrabad S, Bikhof Torbati M. Behvarz M, et al. BMC Med Genomics. 2022 Mar 5;15(1):47. doi: 10.1186/s12920-022-01197-w. BMC Med Genomics. 2022. PMID: 35248021 Free PMC article.

RESULTS: We found a significant difference in the frequencies of heterozygote AB and mutant homozygote BB genotypes in the CATSPER1 (rs2845570) gene polymorphism between patients and healthy controls (p < 0.05). ...However, no significant difference was found in genotyp

…
RESULTS: We found a significant difference in the frequencies of heterozygote AB and mutant homozygote BB genotypes in the CATSPER1 ( …
Human CATSPER1 Promoter Is Regulated by CREB1 and CREMtau Transcriptional Factors In Vitro.
Oviedo N, Ortiz-Borrayo L, Hernández-Sánchez J, Jiménez-Badillo SE, Tesoro-Cruz E, Moreno-Navor E, Aguirre-Alvarado C, Bekker-Méndez VC. Oviedo N, et al. Arch Med Res. 2018 Apr;49(3):135-146. doi: 10.1016/j.arcmed.2018.06.004. Epub 2018 Jul 13. Arch Med Res. 2018. PMID: 30017233
RESULTS: The deletion of the CRE1 site dramatically increased the transcriptional activity of the CATSPER1 promoter in HEK293 and GC1-spg cells. In HEK293 cells, the CREB-A transcription factor positively regulated CATSPER1 gene expression, while the presence of CRE …
RESULTS: The deletion of the CRE1 site dramatically increased the transcriptional activity of the CATSPER1 promoter in HEK293 and GC1 …
Regulation of CATSPER1 expression by the testis-determining gene SRY.
Olivares A, Hernández-Reyes A, Felix R, Forero Á, Mata-Rocha M, Hernández-Sánchez J, Santos I, Aguirre-Alvarado C, Oviedo N. Olivares A, et al. PLoS One. 2018 Oct 31;13(10):e0205744. doi: 10.1371/journal.pone.0205744. eCollection 2018. PLoS One. 2018. PMID: 30379860 Free PMC article.
Previous studies have shown that the murine Catsper1 gene promoter is regulated by different Sox proteins. Likewise, it is acknowledged that the human CATSPER1 gene promoter sequence is enriched in potential interaction sites for the sex-determining region Y gene (S …
Previous studies have shown that the murine Catsper1 gene promoter is regulated by different Sox proteins. Likewise, it is acknowledg …
CatSper channel, sperm function and male fertility.
Singh AP, Rajender S. Singh AP, et al. Reprod Biomed Online. 2015 Jan;30(1):28-38. doi: 10.1016/j.rbmo.2014.09.014. Epub 2014 Oct 8. Reprod Biomed Online. 2015. PMID: 25457194 Review.
CatSper knockout models and application of patch clamp recordings have shown that it is indispensable for male fertility, and mutations and deletions in CatSper gene(s) may lead to infertility. In fact, mutations in CatSper1 and 2 have been identified in infertile individu …
CatSper knockout models and application of patch clamp recordings have shown that it is indispensable for male fertility, and mutations and …
In Silico Analysis of CatSper Family Genes and APOB Gene Regulation in Male Infertility.
Maurya S, Bhoi NR, Kesari KK, Roychoudhury S, Kumar D. Maurya S, et al. Adv Exp Med Biol. 2022;1391:323-332. doi: 10.1007/978-3-031-12966-7_18. Adv Exp Med Biol. 2022. PMID: 36472830
The CatSper genes are the novel family of four sperm-specific Ca(2+)-permeable channels which plays an important role in sperm motility, acrosome reaction, sperm, and oocyte fusion. CatSper1, CatSper2, and CatSper3 are very well-studied genes for their role in asthenozoosp …
The CatSper genes are the novel family of four sperm-specific Ca(2+)-permeable channels which plays an important role in sperm motility, acr …
Effect of selenium and pentoxifylline on expression of CATSPER1 and 2 genes and FSH/LH levels in treated mice by dexamethasone.
Kheradmand N, Kamkar R, Moshajjari M, Baazm M. Kheradmand N, et al. Andrologia. 2019 Jul;51(6):e13279. doi: 10.1111/and.13279. Epub 2019 Apr 14. Andrologia. 2019. PMID: 30983026
In this study, the effect of dexamethasone on expression of CATSPER1 and 2 genes was investigated. These two genes play an important role in sperm motility. ...Based on the results, dexamethasone decreases not only CATSPER1 and 2 gene expression but also serum level …
In this study, the effect of dexamethasone on expression of CATSPER1 and 2 genes was investigated. These two genes play an important …
The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
Ameli M, Moghimian M, Saeb F, Bashtani E, Shokoohi M, Salimnejad R, Abtahi H. Ameli M, et al. Mol Reprod Dev. 2019 Jun;86(6):738-748. doi: 10.1002/mrd.23151. Epub 2019 Apr 30. Mol Reprod Dev. 2019. PMID: 31041823
Then, histomorphometric analysis, hormonal assess, and real-time polymerase chain reaction to measure the expression of CatSper1, CatSper2, LHCGR, and SF1 genes were performed. The results showed that the concentrations of testosterone, follicle-stimulating hormone, and lu …
Then, histomorphometric analysis, hormonal assess, and real-time polymerase chain reaction to measure the expression of CatSper1, Cat …
The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.
Mata-Rocha M, Hernández-Sánchez J, Guarneros G, de la Chesnaye E, Sánchez-Tusié AA, Treviño CL, Felix R, Oviedo N. Mata-Rocha M, et al. FEBS Lett. 2014 Sep 17;588(18):3352-60. doi: 10.1016/j.febslet.2014.07.024. Epub 2014 Aug 4. FEBS Lett. 2014. PMID: 25101494 Free article.
In spite of its central role in male fertility, the transcriptional mechanisms that regulate Catsper1 expression are ill defined. In this work, we describe the identification and characterization of important regulatory elements in the murine Catsper1 gene proximal …
In spite of its central role in male fertility, the transcriptional mechanisms that regulate Catsper1 expression are ill defined. In …
Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia.
Jin ZR, Fang D, Liu BH, Cai J, Tang WH, Jiang H, Xing GG. Jin ZR, et al. Theranostics. 2021 Jan 1;11(6):2822-2844. doi: 10.7150/thno.51869. eCollection 2021. Theranostics. 2021. PMID: 33456575 Free PMC article.
In vivo fertility assay was applied to determine the fertility of rats. CatSper1 knockdown and overexpression experiments were performed to confirm the roles of CatSper channels in the pathogenesis of iAZS and the therapeutic effects of electroacupuncture (EA) treatment on …
In vivo fertility assay was applied to determine the fertility of rats. CatSper1 knockdown and overexpression experiments were perfor …
12 results