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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2013 3
2014 21
2015 46
2016 41
2017 49
2018 58
2019 53
2020 56
2021 54
2022 44
2023 40
2024 13

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407 results

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Page 1
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Larabi A, Barnich N, Nguyen HTT. Larabi A, et al. Autophagy. 2020 Jan;16(1):38-51. doi: 10.1080/15548627.2019.1635384. Epub 2019 Jul 9. Autophagy. 2020. PMID: 31286804 Free PMC article. Review.
A better understanding of the role of autophagy in IBD pathogenesis may provide better sub-classification of IBD phenotypes and novel approaches for disease management.Abbreviations: AIEC: adherent-invasive Escherichia coli; AMPK: AMP-activated protein kinase; ATF6: activating tr …
A better understanding of the role of autophagy in IBD pathogenesis may provide better sub-classification of IBD phenotypes and novel approa …
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Zhang Z, Guo M, Li Y, Shen M, Kong D, Shao J, Ding H, Tan S, Chen A, Zhang F, Zheng S. Zhang Z, et al. Autophagy. 2020 Aug;16(8):1482-1505. doi: 10.1080/15548627.2019.1687985. Epub 2019 Nov 11. Autophagy. 2020. PMID: 31679460 Free PMC article.
Interestingly, ZFP36 plasmid inhibited macroautophagy/autophagy activation by destabilizing ATG16L1 (autophagy related 16 like 1) mRNA. ATG16L1 plasmid eliminated the inhibitory action of ZFP36 plasmid on ferroptosis, and FBXW7 plasmid enhanced the effect of ATG1 …
Interestingly, ZFP36 plasmid inhibited macroautophagy/autophagy activation by destabilizing ATG16L1 (autophagy related 16 like 1) mRN …
Autophagy in the physiological endometrium and cancer.
Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D. Devis-Jauregui L, et al. Autophagy. 2021 May;17(5):1077-1095. doi: 10.1080/15548627.2020.1752548. Epub 2020 May 13. Autophagy. 2021. PMID: 32401642 Free PMC article. Review.
Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.Abbreviations: 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; …
Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.Abbreviations: 3-M …
A comprehensive review and update on Crohn's disease.
Gajendran M, Loganathan P, Catinella AP, Hashash JG. Gajendran M, et al. Dis Mon. 2018 Feb;64(2):20-57. doi: 10.1016/j.disamonth.2017.07.001. Epub 2017 Aug 18. Dis Mon. 2018. PMID: 28826742 Review.
Several genes have been studied so for with respect to CD, but thus far the strong and replicated associations have been identified with NOD2, IL23R and ATG16L1 genes. The risk factors implicated with CD include smoking, low fiber- high carbohydrate diet, altered microbiom …
Several genes have been studied so for with respect to CD, but thus far the strong and replicated associations have been identified with NOD …
Tethering ATG16L1 or LC3 induces targeted autophagic degradation of protein aggregates and mitochondria.
Mei L, Chen X, Wei F, Huang X, Liu L, Yao J, Chen J, Luo X, Wang Z, Yang A. Mei L, et al. Autophagy. 2023 Nov;19(11):2997-3013. doi: 10.1080/15548627.2023.2234797. Epub 2023 Jul 13. Autophagy. 2023. PMID: 37424101
Our results suggested that tethering large target models to phagophore-associated ATG16L1 or LC3 induced targeted autophagic degradation of the large target models. ...Specifically, chimeras consisting of polyQ-binding peptide 1 (QBP) and ATG16L1-binding peptide (AB …
Our results suggested that tethering large target models to phagophore-associated ATG16L1 or LC3 induced targeted autophagic degradat …
Decoy exosomes provide protection against bacterial toxins.
Keller MD, Ching KL, Liang FX, Dhabaria A, Tam K, Ueberheide BM, Unutmaz D, Torres VJ, Cadwell K. Keller MD, et al. Nature. 2020 Mar;579(7798):260-264. doi: 10.1038/s41586-020-2066-6. Epub 2020 Mar 4. Nature. 2020. PMID: 32132711 Free PMC article.
It is unclear, however, whether host species possess innate immune mechanisms that can neutralize pore-forming toxins during infection. We previously showed that the autophagy protein ATG16L1 is necessary for protection against MRSA strains encoding alpha-toxin(4)-a pore-f …
It is unclear, however, whether host species possess innate immune mechanisms that can neutralize pore-forming toxins during infection. We p …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Dayani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, Kim WH, Morris AP, Poustchi H, Newman WG, Midha V, Orchard TR, Vahedi H, Sood A, Sung JY, Malekzadeh R, Westra HJ, Yamazaki K, Yang SK; International Multiple Sclerosis Genetics Consortium; International IBD Genetics Consortium; Barrett JC, Alizadeh BZ, Parkes M, Bk T, Daly MJ, Kubo M, Anderson CA, Weersma RK. Liu JZ, et al. Nat Genet. 2015 Sep;47(9):979-986. doi: 10.1038/ng.3359. Epub 2015 Jul 20. Nat Genet. 2015. PMID: 26192919 Free PMC article.
Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biolo …
Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allel …
Identification and Validation of Autophagy-Related Genes in Chronic Obstructive Pulmonary Disease.
Sun S, Shen Y, Wang J, Li J, Cao J, Zhang J. Sun S, et al. Int J Chron Obstruct Pulmon Dis. 2021 Jan 12;16:67-78. doi: 10.2147/COPD.S288428. eCollection 2021. Int J Chron Obstruct Pulmon Dis. 2021. PMID: 33469280 Free PMC article.
The results of qRT-PCR showed that the expression levels of HIF1A, CDKN1A, BAG3, ERBB2 and ATG16L1 in COPD patients and healthy controls were consistent with the bioinformatics analysis results from mRNA microarray. CONCLUSION: We identified 40 potential autophagy-related …
The results of qRT-PCR showed that the expression levels of HIF1A, CDKN1A, BAG3, ERBB2 and ATG16L1 in COPD patients and healthy contr …
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, Huo L, Yu Y, Chen Y, Gong R, Wu Y, Zhang R, Zhong L, Wang X, Chen Q, Gao S, Jiang Z, Wei D, Kang T. Gao Y, et al. Cell Res. 2022 Dec;32(12):1086-1104. doi: 10.1038/s41422-022-00731-w. Epub 2022 Oct 24. Cell Res. 2022. PMID: 36280710 Free PMC article.
Mechanistically, RAB22A engages PI4K2A to generate PI4P that recruits the Atg12-Atg5-Atg16L1 complex, inducing the formation of ER-derived RAB22A-mediated non-canonical autophagosome, in which STING activated by agonists or chemoradiotherapy is packaged. ...
Mechanistically, RAB22A engages PI4K2A to generate PI4P that recruits the Atg12-Atg5-Atg16L1 complex, inducing the formation of ER-de …
V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy.
Hooper KM, Jacquin E, Li T, Goodwin JM, Brumell JH, Durgan J, Florey O. Hooper KM, et al. J Cell Biol. 2022 Jun 6;221(6):e202105112. doi: 10.1083/jcb.202105112. Epub 2022 May 5. J Cell Biol. 2022. PMID: 35511089 Free PMC article.
CASM is activated by engulfment (endocytosis, phagocytosis), agonists (STING, TRPML1), and infection (influenza), dependent on K490 in the ATG16L1 WD40-domain. However, factors associated with non-canonical ATG16L1 recruitment and CASM induction remain unknown. ...F …
CASM is activated by engulfment (endocytosis, phagocytosis), agonists (STING, TRPML1), and infection (influenza), dependent on K490 in the …
407 results