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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1927 1
1930 1
1931 2
1948 1
1955 1
1957 2
1959 2
1960 1
1962 3
1963 3
1964 4
1965 3
1966 6
1967 4
1968 2
1969 6
1970 8
1971 3
1972 5
1973 15
1974 10
1975 29
1976 32
1977 26
1978 30
1979 29
1980 48
1981 47
1982 71
1983 62
1984 69
1985 84
1986 180
1987 212
1988 311
1989 378
1990 508
1991 459
1992 548
1993 555
1994 576
1995 636
1996 618
1997 555
1998 572
1999 518
2000 647
2001 670
2002 694
2003 712
2004 747
2005 724
2006 803
2007 803
2008 902
2009 963
2010 1003
2011 1081
2012 1060
2013 830
2014 784
2015 726
2016 811
2017 1061
2018 1133
2019 1250
2020 1388
2021 1377
2022 1310
2023 1220
2024 538

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27,987 results

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The following term was not found in PubMed: -6-phenothiazin-10-ylhexan-2-ol
Page 1
Clinical significance of soluble interleukin-2 receptor measurement in immune-mediated diseases.
Dik WA, Heron M. Dik WA, et al. Neth J Med. 2020 Sep;78(5):220-231. Neth J Med. 2020. PMID: 33093245 Free article. Review.
A soluble form of the interleukin-2 receptor (sIL-2R) is secreted upon T-cell activation. Increased blood levels of sIL-2R occur in a variety of immunological diseases. Although the biological function of sIL-2R is incompletely understood, both in health and …
A soluble form of the interleukin-2 receptor (sIL-2R) is secreted upon T-cell activation. Increased blood levels of sIL-2R occ …
The IL-2 - IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor.
Damoiseaux J. Damoiseaux J. Clin Immunol. 2020 Sep;218:108515. doi: 10.1016/j.clim.2020.108515. Epub 2020 Jul 1. Clin Immunol. 2020. PMID: 32619646 Free article. Review.
Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicti …
Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the p …
9-(4-(2-[18F]Fluoroethyl)benzyl)-9-azabicyclo[3.3.1]nonan-3-yl-2-methoxy-5-methyl-phenylcarbamate.
Chopra A. Chopra A. 2009 Nov 10 [updated 2009 Dec 9]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2009 Nov 10 [updated 2009 Dec 9]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641520 Free Books & Documents. Review.
Sigma receptors (SR) are known to exist as subtypes 1 (Sig-1R) and 2 (Sig-2R) and are found in the central nervous system and the peripheral tissues. ...Biodistribution of the labeled compound was also studied in mice bearing murine EMT-6 cell tumors that express the Sig- …
Sigma receptors (SR) are known to exist as subtypes 1 (Sig-1R) and 2 (Sig-2R) and are found in the central nervous system and the per …
Dichloridobis[(1S,1S',2R,2R')-(+)-1,1'-di-tert-butyl-2,2'-diphospho-lane-kappaP,P']ruthenium(II).
Wang C, Tao H, Ji B. Wang C, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 May 3;64(Pt 6):m754. doi: 10.1107/S1600536808008301. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202447 Free PMC article.
The slightly distorted octa-hedral environment of the Ru center is formed by four P atoms [Ru-P = 2.4417 (6) and 2.4544 (6) A] from two different (1S,1S',2R,2R')-TangPhos ligands [(1S,1S',2R,2R')-TangPhos = (1S,1S',2R,2R')-(+)-1,1'-di-ter …
The slightly distorted octa-hedral environment of the Ru center is formed by four P atoms [Ru-P = 2.4417 (6) and 2.4544 (6) A] from two diff …
The IL-2 - IL-2 receptor pathway: Key to understanding multiple sclerosis.
Peerlings D, Mimpen M, Damoiseaux J. Peerlings D, et al. J Transl Autoimmun. 2021 Sep 21;4:100123. doi: 10.1016/j.jtauto.2021.100123. eCollection 2021. J Transl Autoimmun. 2021. PMID: 35005590 Free PMC article. Review.
Furthermore, another factor of this pathway, the soluble form of the IL-2R (sIL-2R), further complicates understanding the role of the IL-2 - IL-2R pathway in MS. ...In this review, first, the current knowledge of MS and the IL-2 - IL-2R pathway are su …
Furthermore, another factor of this pathway, the soluble form of the IL-2R (sIL-2R), further complicates understanding the rol …
Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects.
Xie NZ, Chen XR, Wang QY, Chen D, Du QS, Zhou GP, Huang RB. Xie NZ, et al. Curr Top Med Chem. 2017;17(21):2433-2439. doi: 10.2174/1568026617666170504101646. Curr Top Med Chem. 2017. PMID: 28474550 Review.
(2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. ...In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the developmen …
(2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. ...In …
(2R,6S)-tert-Butyl 2-(benzhydryl-carbamo-yl)-6-methyl-morpholine-4-carboxyl-ate.
Wang H, Xia G, Liu X, Shen J. Wang H, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1437. doi: 10.1107/S1600536811017764. Epub 2011 May 20. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21754815 Free PMC article.
The title compound, C(24)H(30)N(2)O(4), was obtained by the reaction of (2R,6S)-4-(tert-but-oxy-carbon-yl)-6-methyl-morpho-line-2-carb-oxy-lic acid with diphenyl-methanamine in dimethyl-formamide solution. ...
The title compound, C(24)H(30)N(2)O(4), was obtained by the reaction of (2R,6S)-4-(tert-but-oxy-carbon-yl)-6-methyl-morpho-line-2-car …
Antinociceptive and Analgesic Effects of (2R,6R)-Hydroxynorketamine.
Yost JG, Wulf HA, Browne CA, Lucki I. Yost JG, et al. J Pharmacol Exp Ther. 2022 Sep;382(3):256-265. doi: 10.1124/jpet.122.001278. Epub 2022 Jul 2. J Pharmacol Exp Ther. 2022. PMID: 35779947 Free PMC article.
Blockade of opioid receptors with naltrexone partially prevented the antinociceptive effect of ketamine but was ineffective against (2R,6R)-HNK. Furthermore, (2R,6R)-HNK did not produce dystaxia, even when tested at doses five times greater than those needed to prod …
Blockade of opioid receptors with naltrexone partially prevented the antinociceptive effect of ketamine but was ineffective against (2R …
Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations.
Abate C, Niso M, Berardi F. Abate C, et al. Future Med Chem. 2018 Aug 1;10(16):1997-2018. doi: 10.4155/fmc-2018-0072. Epub 2018 Jul 3. Future Med Chem. 2018. PMID: 29966437 Review.
Identification of sigma-2 receptor (sig-2R) has been controversial. Nevertheless, interest in sig-2R is high for its overexpression in tumors and potentials in oncology. ...The most representative classes of sig-2R ligands are herein treated with focus on com …
Identification of sigma-2 receptor (sig-2R) has been controversial. Nevertheless, interest in sig-2R is high for its overexpre …
(2R,6R)-hydroxynorketamine exerts mGlu(2) receptor-dependent antidepressant actions.
Zanos P, Highland JN, Stewart BW, Georgiou P, Jenne CE, Lovett J, Morris PJ, Thomas CJ, Moaddel R, Zarate CA Jr, Gould TD. Zanos P, et al. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6441-6450. doi: 10.1073/pnas.1819540116. Epub 2019 Mar 13. Proc Natl Acad Sci U S A. 2019. PMID: 30867285 Free PMC article.
In contrast, ketamine, when administered as a single subanesthetic dose, exerts rapid and sustained antidepressant actions. Preclinical studies indicate that the ketamine metabolite (2R,6R)-hydroxynorketamine [(2R,6R)-HNK] is a rapid-acting antidepressant drug candi …
In contrast, ketamine, when administered as a single subanesthetic dose, exerts rapid and sustained antidepressant actions. Preclinical stud …
27,987 results
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