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The following term was not found in PubMed: 6-trimethylcycloheptanol
Page 1
2-{(1R,2R)-2-[Bis(4-methyl-benz-yl)amino]-cyclo-hex-yl}isoindoline-1,3-dione.
Li C, Fu XK, Wu CL, Huang J. Li C, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1483. doi: 10.1107/S1600536811018101. Epub 2011 May 20. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21754852 Free PMC article.
In the title mol-ecule, C(30)H(32)N(2)O(2), the two tolyl rings form dihedral angles of 65.8 (1) and 6.6 (1) with the isoindole-1,3-dione mean plane. The cyclo-hexane ring adopts a chair conformation....
In the title mol-ecule, C(30)H(32)N(2)O(2), the two tolyl rings form dihedral angles of 65.8 (1) and 6.6 (1) with the isoindol …
Eliglustat.
[No authors listed] [No authors listed] 2020 Apr 20. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2020 Apr 20. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 32352701 Free Books & Documents. Review.
Glecaprevir.
[No authors listed] [No authors listed] 2023 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2023 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30222286 Free Books & Documents. Review.
Grazoprevir.
[No authors listed] [No authors listed] 2023 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2023 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 29999878 Free Books & Documents. Review.
2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.
Saeed A, Vaught GM, Gavardinas K, Matthews D, Green JE, Losada PG, Bullock HA, Calvert NA, Patel NJ, Sweetana SA, Krishnan V, Henck JW, Luz JG, Wang Y, Jadhav P. Saeed A, et al. J Med Chem. 2016 Jan 28;59(2):750-5. doi: 10.1021/acs.jmedchem.5b01168. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26683992
A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) and liver-mediated decrease in HDL-C. 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)amino]-3-methyl-benzonitrile …
A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign …
Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y. Chen G, et al. Nat Commun. 2022 May 2;13(1):2375. doi: 10.1038/s41467-022-30081-5. Nat Commun. 2022. PMID: 35501348 Free PMC article.
Here we present cryo-EM structures of the human GPR88-Gi1 signaling complex with or without a synthetic agonist (1R, 2R)-2-PCCA. We show that (1R, 2R)-2-PCCA is an allosteric modulator binding to a herein identified pocket formed by the c …
Here we present cryo-EM structures of the human GPR88-Gi1 signaling complex with or without a synthetic agonist (1R, 2R)-2 …
Jasmonates from Chinese acorns (Quercus serrata var. brevipetiolata) exert pronounced anti-neuroinflammatory activities.
Wang Y, Lei Y, Huang Y, Wang Z, Xu J, He X. Wang Y, et al. Bioorg Chem. 2020 Oct;103:104143. doi: 10.1016/j.bioorg.2020.104143. Epub 2020 Jul 28. Bioorg Chem. 2020. PMID: 32750609
In this study, ten jasmonates were isolated and purified from Chinese acorn, including five new (1-5) and five known jasmonates (6-10). The new jasmonates were identified as butyl (1R,2R)-2-[(2'Z)-5'-hydroxy-penten-2'-enyl]-3-oxo-cyclopentane acetate ( …
In this study, ten jasmonates were isolated and purified from Chinese acorn, including five new (1-5) and five known jasmonates (6-10 …
Development of versatile cis- and trans-dicarbon-substituted chiral cyclopropane units: synthesis of (1S,2R)- and (1R,2R)-2-aminomethyl-1-(1H-imidazol-4-yl)cyclopropanes and their enantiomers as conformationally restricted analogues of histamine.
Kazuta Y, Matsuda A, Shuto S. Kazuta Y, et al. J Org Chem. 2002 Mar 8;67(5):1669-77. doi: 10.1021/jo010852x. J Org Chem. 2002. PMID: 11871901
The cyclopropane ring can be used effectively in restricting the conformation of biologically active compounds to improve activity and also to investigate bioactive conformations. We designed (1S,2R)- and (1R,2R)-2-aminomethyl-1-(1H-imidazol-4-yl)cyclopropane …
The cyclopropane ring can be used effectively in restricting the conformation of biologically active compounds to improve activity and also …
49 results