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The following term was not found in PubMed: 1-cyclohexyl-2-piperidylidene
Page 1
Amine coupling through EDC/NHS: a practical approach.
Fischer MJ. Fischer MJ. Methods Mol Biol. 2010;627:55-73. doi: 10.1007/978-1-60761-670-2_3. Methods Mol Biol. 2010. PMID: 20217613
The most common technique for linking ligands covalently to a hydrophilic solid surface is amine coupling via reactive esters. In this chapter detailed methods and problem discussions will be given to assist in fast decision analysis to optimize immobilization and regenera …
The most common technique for linking ligands covalently to a hydrophilic solid surface is amine coupling via reactive esters. In thi …
Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones.
Khramtsova EE, Lystsova EA, Khokhlova EV, Dmitriev MV, Maslivets AN. Khramtsova EE, et al. Molecules. 2021 Nov 26;26(23):7179. doi: 10.3390/molecules26237179. Molecules. 2021. PMID: 34885757 Free PMC article.
We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported approaches (reactions of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones with amines). The developed approach is based on the thermal decomposit …
We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported ap …
1,2-Diamines as the Amine Sources in Amidation and Rhodium-Catalyzed Asymmetric Reductive Amination Cascade Reactions.
Xie R, Liu C, Lin R, Zhang R, Huang H, Chang M. Xie R, et al. Org Lett. 2022 Aug 12;24(31):5646-5650. doi: 10.1021/acs.orglett.2c01728. Epub 2022 Aug 2. Org Lett. 2022. PMID: 35916628
The sturdy chelation of 1,2-diamines and transition-metals would retard or even interrupt the routine catalytic cycles. In the amidation and asymmetric reductive amination (ARA) cascade reactions of diamines and ketoesters, we deployed sets of additives to ensure a smooth …
The sturdy chelation of 1,2-diamines and transition-metals would retard or even interrupt the routine catalytic cycles. In the amidation and …
Recent Advances in 1,2-Amino(hetero)arylation of Alkenes.
Kwon Y, Wang Q. Kwon Y, et al. Chem Asian J. 2022 Jun 15;17(12):e202200215. doi: 10.1002/asia.202200215. Epub 2022 May 3. Chem Asian J. 2022. PMID: 35460596 Free PMC article. Review.
Next, two-component reactions will be discussed with different combination of precursors, N-tethered alkenes and external aryl precursor, C-tethered alkenes and external amine precursor, or C, N-tethered reagents, and alkenes. Last, three-component intermolecular amino(het …
Next, two-component reactions will be discussed with different combination of precursors, N-tethered alkenes and external aryl precursor, C- …
Catalytic Atroposelective Electrophilic Amination of Indoles.
Qin J, Zhou T, Zhou TP, Tang L, Zuo H, Yu H, Wu G, Wu Y, Liao RZ, Zhong F. Qin J, et al. Angew Chem Int Ed Engl. 2022 Aug 1;61(31):e202205159. doi: 10.1002/anie.202205159. Epub 2022 Jun 13. Angew Chem Int Ed Engl. 2022. PMID: 35612900
Reported here is the first catalytic atroposelective electrophilic amination of indoles, which delivers functionalized atropochiral N-sulfonyl-3-arylaminoindoles with excellent optical purity. ...This method is valuable with respect to enlarging the toolbox for atropochira …
Reported here is the first catalytic atroposelective electrophilic amination of indoles, which delivers functionalized atropochiral N …
Asymmetric Biomimetic Transamination of Trifluoromethyl Ketones.
Cai W, Cai D, Liang H, Ren X, Zhao B. Cai W, et al. J Org Chem. 2023 Jun 16;88(12):7849-7857. doi: 10.1021/acs.joc.2c02329. Epub 2023 Jan 25. J Org Chem. 2023. PMID: 36696680
In the presence of chiral pyridoxamine 4b as the catalyst and 2,2-diphenylglycine (3) as the amine source, asymmetric biomimetic transamination of trifluoromethyl ketones produces optically active alpha-trifluoromethyl amines 6 in 81-98% yields with 88-95% ee's unde …
In the presence of chiral pyridoxamine 4b as the catalyst and 2,2-diphenylglycine (3) as the amine source, asymmetric biomimetic tran …
General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald-Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles.
Gribanov PS, Philippova AN, Topchiy MA, Minaeva LI, Asachenko AF, Osipov SN. Gribanov PS, et al. Molecules. 2022 Mar 20;27(6):1999. doi: 10.3390/molecules27061999. Molecules. 2022. PMID: 35335361 Free PMC article.
The method is based on Buchwald-Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines, respectively. As result, it was found that palladium complex [(THP-Dipp)Pd(cinn)Cl] bearing expanded-ring N-heterocyclic carbene ligand i …
The method is based on Buchwald-Hartwig cross-coupling reaction of 5-Amino or 5-Halo-1,2,3-triazoles with (het)aryl halides and amines …
Palladium N-Heterocyclic Carbene-Catalyzed Aminations: An Outline.
Umabharathi SB, Neetha M, Anilkumar G. Umabharathi SB, et al. Top Curr Chem (Cham). 2024 Jan 24;382(1):3. doi: 10.1007/s41061-024-00449-w. Top Curr Chem (Cham). 2024. PMID: 38265533 Review.
Amination offers the potential to fine tune the properties of natural products and produce functional materials for various applications. ...This review outlines the advancements in Pd-NHC-catalyzed amination reactions, covering literature up to date....
Amination offers the potential to fine tune the properties of natural products and produce functional materials for various applicati …
CuCl-photocatalyzed C-H amination of benzoxazoles.
Li GN, Li HC, Lu Z, Yu B. Li GN, et al. Org Biomol Chem. 2022 Jun 29;20(25):5125-5128. doi: 10.1039/d2ob00687a. Org Biomol Chem. 2022. PMID: 35704388
The direct coupling of benzoxazoles and amines was realized by visible light irradiation and CuCl catalysis. Various aminated benzoxazoles were successfully synthesized under mild conditions with air as an oxidant....
The direct coupling of benzoxazoles and amines was realized by visible light irradiation and CuCl catalysis. Various aminated …
Reductive Amination in the Synthesis of Pharmaceuticals.
Afanasyev OI, Kuchuk E, Usanov DL, Chusov D. Afanasyev OI, et al. Chem Rev. 2019 Dec 11;119(23):11857-11911. doi: 10.1021/acs.chemrev.9b00383. Epub 2019 Oct 21. Chem Rev. 2019. PMID: 31633341 Review.
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. ...Recent studies show that at least a quarter of C-N bond-forming reactions …
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous …
1,122,788 results
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