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Propargylamine: an important moiety in drug discovery.
Carneiro A, Uriarte E, Borges F, Matos MJ. Carneiro A, et al. Future Med Chem. 2023 Jan;15(2):211-224. doi: 10.4155/fmc-2022-0243. Epub 2023 Feb 21. Future Med Chem. 2023. PMID: 36802855 Review.
Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer's Disease.
Bhatia R, Chakrabarti SS, Kaur U, Parashar G, Banerjee A, Rawal RK. Bhatia R, et al. Curr Alzheimer Res. 2021;18(10):802-830. doi: 10.2174/1567205018666211208140551. Curr Alzheimer Res. 2021. PMID: 34879800 Review.
These include hybrids of coumarin with carbazole, benzofuran, dithiocarbamate, quinoline, pargyline, tacrine, N-benzyl pyridinium, donepezil, purine, piperidine, morpholine, aminophenol, benzylamino, halophenylalkylamidic, thiazole, thiourea, hydroxypyridinone, triazole, p …
These include hybrids of coumarin with carbazole, benzofuran, dithiocarbamate, quinoline, pargyline, tacrine, N-benzyl pyridinium, do …
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies.
Bhawna, Kumar A, Bhatia M, Kapoor A, Kumar P, Kumar S. Bhawna, et al. Eur J Med Chem. 2022 Nov 15;242:114655. doi: 10.1016/j.ejmech.2022.114655. Epub 2022 Aug 18. Eur J Med Chem. 2022. PMID: 36037788 Review.
Clinically approved MAO inhibitors for example selegiline, rasagiline, clorgyline, pargyline etc. are irreversible in nature and cause some adverse effects while recently studied reversible MAO inhibitors are devoid of harmful effects of old monoamine oxidase inhibitors. . …
Clinically approved MAO inhibitors for example selegiline, rasagiline, clorgyline, pargyline etc. are irreversible in nature and caus …