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Year Number of Results
2018 1
2019 70
2020 95
2021 82
2022 39
2023 42
2024 11

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301 results

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Page 1
Molecular Features of Cancer-associated Fibroblast Subtypes and their Implication on Cancer Pathogenesis, Prognosis, and Immunotherapy Resistance.
Galbo PM Jr, Zang X, Zheng D. Galbo PM Jr, et al. Clin Cancer Res. 2021 May 1;27(9):2636-2647. doi: 10.1158/1078-0432.CCR-20-4226. Epub 2021 Feb 23. Clin Cancer Res. 2021. PMID: 33622705 Free PMC article.
In addition, we identified novel transcriptional drivers (MEF2C, TWIST1, NR1H3, RELB, and FOXM1) key to CAF heterogeneity. Furthermore, we showed that CAF subtypes were associated with different clinical outcomes and uncovered key molecular pathways that could activate or …
In addition, we identified novel transcriptional drivers (MEF2C, TWIST1, NR1H3, RELB, and FOXM1) key to CAF heterogeneity. Furthermor …
A multi-stem cell basis for craniosynostosis and calvarial mineralization.
Bok S, Yallowitz AR, Sun J, McCormick J, Cung M, Hu L, Lalani S, Li Z, Sosa BR, Baumgartner T, Byrne P, Zhang T, Morse KW, Mohamed FF, Ge C, Franceschi RT, Cowling RT, Greenberg BH, Pisapia DJ, Imahiyerobo TA, Lakhani S, Ross ME, Hoffman CE, Debnath S, Greenblatt MB. Bok S, et al. Nature. 2023 Sep;621(7980):804-812. doi: 10.1038/s41586-023-06526-2. Epub 2023 Sep 20. Nature. 2023. PMID: 37730988 Free PMC article.
Craniosynostosis is a group of disorders of premature calvarial suture fusion. ...Deletion of Twist1, a gene associated with craniosynostosis in humans(2,3), solely in CTSK(+) CSCs is sufficient to drive craniosynostosis in mice, but the sites that are …
Craniosynostosis is a group of disorders of premature calvarial suture fusion. ...Deletion of Twist1, a gene associated with …
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme.
Kim S, Morgunova E, Naqvi S, Goovaerts S, Bader M, Koska M, Popov A, Luong C, Pogson A, Swigut T, Claes P, Taipale J, Wysocka J. Kim S, et al. Cell. 2024 Feb 1;187(3):692-711.e26. doi: 10.1016/j.cell.2023.12.032. Epub 2024 Jan 22. Cell. 2024. PMID: 38262408 Free article.
Coordinator guides cooperative and selective binding between the bHLH family mesenchymal regulator TWIST1 and a collective of HD factors associated with regional identities in the face and limb. TWIST1 is required for HD binding and open chromatin at Coordinator sit …
Coordinator guides cooperative and selective binding between the bHLH family mesenchymal regulator TWIST1 and a collective of HD fact …
Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors.
Zhang F, Zhang Q, Zhu J, Yao B, Ma C, Qiao N, He S, Ye Z, Wang Y, Han R, Feng J, Wang Y, Qin Z, Ma Z, Li K, Zhang Y, Tian S, Chen Z, Tan S, Wu Y, Ran P, Wang Y, Ding C, Zhao Y. Zhang F, et al. Cell Res. 2022 Dec;32(12):1047-1067. doi: 10.1038/s41422-022-00736-5. Epub 2022 Oct 28. Cell Res. 2022. PMID: 36307579 Free PMC article.
Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1 …
Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune s …
Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes.
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC. Souilhol C, et al. Nat Rev Cardiol. 2020 Jan;17(1):52-63. doi: 10.1038/s41569-019-0239-5. Epub 2019 Jul 31. Nat Rev Cardiol. 2020. PMID: 31366922 Review.
In this Review, we describe these studies, which reveal that shear stress regulates diverse processes and demonstrate that multiple pathways classically known to be involved in embryonic development, such as BMP-TGFbeta, WNT, Notch, HIF1alpha, TWIST1 and HOX family genes, …
In this Review, we describe these studies, which reveal that shear stress regulates diverse processes and demonstrate that multiple pathways …
lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/beta-catenin signaling.
Pan J, Fang S, Tian H, Zhou C, Zhao X, Tian H, He J, Shen W, Meng X, Jin X, Gong Z. Pan J, et al. Mol Cancer. 2020 Jan 15;19(1):9. doi: 10.1186/s12943-020-1133-9. Mol Cancer. 2020. PMID: 31941509 Free PMC article.
BACKGROUND: MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signaling remains largely unknown. ...Interestingly, …
BACKGROUND: MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well estab …
Single-nucleus chromatin accessibility identifies a critical role for TWIST1 in idiopathic pulmonary fibrosis myofibroblast activity.
Valenzi E, Bahudhanapati H, Tan J, Tabib T, Sullivan DI, Nouraie M, Sembrat J, Fan L, Chen K, Liu S, Rojas M, Lafargue A, Felsher DW, Tran PT, Kass DJ, Lafyatis R. Valenzi E, et al. Eur Respir J. 2023 Jul 7;62(1):2200474. doi: 10.1183/13993003.00474-2022. Print 2023 Jul. Eur Respir J. 2023. PMID: 37142338 Free PMC article.
We performed RNA-sequencing on pulmonary fibroblasts of bleomycin-injured Twist1-overexpressing COL1A2 Cre-ER mice to examine alterations in fibrosis-relevant pathways following Twist1 overexpression in collagen-producing cells. ...TWIST1 expression was selec …
We performed RNA-sequencing on pulmonary fibroblasts of bleomycin-injured Twist1-overexpressing COL1A2 Cre-ER mice to examine alterat …
Animal models of craniosynostosis.
Cornille M, Dambroise E, Komla-Ebri D, Kaci N, Biosse-Duplan M, Di Rocco F, Legeai-Mallet L. Cornille M, et al. Neurochirurgie. 2019 Nov;65(5):202-209. doi: 10.1016/j.neuchi.2019.09.010. Epub 2019 Sep 26. Neurochirurgie. 2019. PMID: 31563616 Review.
BACKGROUND: Various animal models mimicking craniosynostosis have been developed, using mutant zebrafish and mouse. ...MATERIAL AND METHODS: The relevant literature for animal models of craniosynostosis was reviewed. RESULTS: Although few studies on craniosynosto …
BACKGROUND: Various animal models mimicking craniosynostosis have been developed, using mutant zebrafish and mouse. ...MATERIAL AND M …
Molecular Mechanisms Involved in Craniosynostosis.
Yapijakis C, Pachis N, Sotiriadou T, Vaila C, Michopoulou V, Vassiliou S. Yapijakis C, et al. In Vivo. 2023 Jan-Feb;37(1):36-46. doi: 10.21873/invivo.13052. In Vivo. 2023. PMID: 36593018 Free PMC article. Review.
In most cases (85%), craniosynostosis is presented as sporadic anomaly (non-syndromic craniosynostosis), while in other cases (15%) as part of syndromes (syndromic craniosynostosis). ...The main gene mutations in craniosynostosis involve FGFR1, FGFR2, …
In most cases (85%), craniosynostosis is presented as sporadic anomaly (non-syndromic craniosynostosis), while in other cases …
LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway.
Wu N, Jiang M, Liu H, Chu Y, Wang D, Cao J, Wang Z, Xie X, Han Y, Xu B. Wu N, et al. Cell Death Differ. 2021 Jan;28(1):219-232. doi: 10.1038/s41418-020-0596-y. Epub 2020 Jul 31. Cell Death Differ. 2021. PMID: 32737443 Free PMC article.
Mechanistically, LINC00941 activated EMT in CRC cells, as indicated by the increased expression of key molecular markers of cell invasion and metastasis (Vimentin, Fibronectin, and Twist1) and simultaneous decreased expression of the main invasion suppressors E-cadherin an …
Mechanistically, LINC00941 activated EMT in CRC cells, as indicated by the increased expression of key molecular markers of cell invasion an …
301 results