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LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. Stein BD, et al. Cancer Discov. 2023 Apr 3;13(4):1002-1025. doi: 10.1158/2159-8290.CD-22-0805. Cancer Discov. 2023. PMID: 36715544 Free PMC article.
Here, we provide a mechanistic explanation for this difference by uncovering an evolutionary divergence in the regulation of triosephosphate isomerase (TPI1). In hLUAD, TPI1 activity is regulated via phosphorylation at Ser21 by the salt inducible kinases (SIK) in an …
Here, we provide a mechanistic explanation for this difference by uncovering an evolutionary divergence in the regulation of triosephosphate …
Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry.
Li JD, Chen Y, Jing SW, Wang LT, Zhou YH, Liu ZS, Song C, Li DZ, Wang HQ, Huang ZG, Dang YW, Chen G, Luo JY. Li JD, et al. Eur J Med Res. 2023 Dec 15;28(1):591. doi: 10.1186/s40001-023-01568-8. Eur J Med Res. 2023. PMID: 38102653 Free PMC article.
Quantities of studies demonstrate that glycolytic reprograming is essential for the progression of cancers, where triosephosphate isomerase 1 (TPI1) serves as a catalytic enzyme. However, the clinicopathological significance and potential biological fu …
Quantities of studies demonstrate that glycolytic reprograming is essential for the progression of cancers, where triosephosphate …
TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
Jin X, Wang D, Lei M, Guo Y, Cui Y, Chen F, Sun W, Chen X. Jin X, et al. J Transl Med. 2022 May 4;20(1):191. doi: 10.1186/s12967-022-03370-2. J Transl Med. 2022. PMID: 35509067 Free PMC article.
BACKGROUND: Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. ...Moreover, TPI1 interacts with sequestosome-1 (SQSTM1)/P62, and P62 decreases the protein expression of TPI1 by promoting it …
BACKGROUND: Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. …
Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance.
Liu P, Sun SJ, Ai YJ, Feng X, Zheng YM, Gao Y, Zhang JY, Zhang L, Sun YP, Xiong Y, Lin M, Yuan HX. Liu P, et al. Cell Death Dis. 2022 Mar 4;13(3):205. doi: 10.1038/s41419-022-04655-6. Cell Death Dis. 2022. PMID: 35246510 Free PMC article.
This analysis not only confirms genes that are known to be involved in tumorigenesis, but also reveals a significant correlation of triosephosphate isomerase 1 (TPI1) with poor prognosis, especially in lung adenocarcinoma (LUAD). ...Our study uncovers …
This analysis not only confirms genes that are known to be involved in tumorigenesis, but also reveals a significant correlation of trios …
Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target.
Enríquez-Flores S, Flores-López LA, García-Torres I, de la Mora-de la Mora I, Cabrera N, Gutiérrez-Castrellón P, Martínez-Pérez Y, López-Velázquez G. Enríquez-Flores S, et al. Biomolecules. 2020 Jul 15;10(7):1050. doi: 10.3390/biom10071050. Biomolecules. 2020. PMID: 32679775 Free PMC article.
TPI1 promotes MAPK/ERK-induced EMT, cell migration and invasion in lung adenocarcinoma.
Li Y, Pan B, Zhang F, Jia X, Zhu X, Tong X, Zhao J, Li C. Li Y, et al. Thorac Cancer. 2024 Feb;15(4):327-338. doi: 10.1111/1759-7714.15196. Epub 2023 Dec 21. Thorac Cancer. 2024. PMID: 38130074 Free PMC article.
BACKGROUND: Triosephosphate isomerase 1 (TPI1), as a widely involved glycolytic enzyme, plays a significant role in glucose metabolism and is highly expressed in various tumors. ...Meanwhile, overexpression of TPI1 promoted the epithelial-mesenc …
BACKGROUND: Triosephosphate isomerase 1 (TPI1), as a widely involved glycolytic enzyme, plays a significant role …
TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis.
Liu BHM, Tey SK, Mao X, Ma APY, Yeung CLS, Wong SWK, Ng TH, Xu Y, Yao Y, Fung EYM, Tan KV, Khong PL, Ho DW, Ng IO, Tang AHN, Cai SH, Yun JP, Yam JWP. Liu BHM, et al. J Extracell Vesicles. 2021 Aug;10(10):e12135. doi: 10.1002/jev2.12135. Epub 2021 Aug 11. J Extracell Vesicles. 2021. PMID: 34401050 Free PMC article.
Conversely, EVs released from normal liver cells with Rab20 knockdown loses suppressive effect on HCC cell growth and motility. Proteomic profiling revealed the level of triosephosphate isomerase 1 (TPI1), a glycolytic enzyme, in EVs to be positively a …
Conversely, EVs released from normal liver cells with Rab20 knockdown loses suppressive effect on HCC cell growth and motility. Proteomic pr …
Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.
Lei M, Tao MQ, Wu YJ, Xu L, Yang Z, Li Y, Olatunji OJ, Wang XW, Zuo J. Lei M, et al. Front Immunol. 2022 Jan 17;12:795626. doi: 10.3389/fimmu.2021.795626. eCollection 2021. Front Immunol. 2022. PMID: 35111160 Free PMC article.
Meanwhile, RANTES levels were relatively low when NAMPT and TPI1 were overexpressed. Reciprocal interactions between TPI1 and HIF-1alpha were observed. HIF-1alpha promoted TPI1 expression, while TPI1 co-localized with HIF-1alpha in nucleus of inflammat …
Meanwhile, RANTES levels were relatively low when NAMPT and TPI1 were overexpressed. Reciprocal interactions between TPI1 and …
Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo.
Roland BP, Richards KR, Hrizo SL, Eicher S, Barile ZJ, Chang TC, Savon G, Bianchi P, Fermo E, Ricerca BM, Tortorolo L, Vockley J, VanDemark AP, Palladino MJ. Roland BP, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2257-2266. doi: 10.1016/j.bbadis.2019.05.002. Epub 2019 May 7. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31075491 Free PMC article.
23 results