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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2006 1
2007 2
2008 1
2014 2
2015 1
2016 4
2017 1
2018 3
2019 2
2021 2
2022 4
2023 3
2024 2

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24 results

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Page 1
Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus.
Huang S, Xiang C, Song Y. Huang S, et al. PLoS One. 2022 Mar 10;17(3):e0265221. doi: 10.1371/journal.pone.0265221. eCollection 2022. PLoS One. 2022. PMID: 35271662 Free PMC article.
RESULTS: A total of 1765 and 2155 DEGs of sarcopenia and T2DM were screened, respectively. 15 common genes (LXN, CIB2, PEA15, KANK2, FGD1, NMRK1, PLCB1, SEMA4G, ADARB1, UPF3A, CSTB, COL3A1, CD99, ETV3, FJX1) correlated with sarcopenia and T2DM simultaneously were then iden …
RESULTS: A total of 1765 and 2155 DEGs of sarcopenia and T2DM were screened, respectively. 15 common genes (LXN, CIB2, PEA15, KANK2, …
Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
Lončarić M, Stojanović N, Rac-Justament A, Coopmans K, Majhen D, Humphries JD, Humphries MJ, Ambriović-Ristov A. Lončarić M, et al. Cell Mol Biol Lett. 2023 Jul 17;28(1):56. doi: 10.1186/s11658-023-00473-6. Cell Mol Biol Lett. 2023. PMID: 37460977 Free PMC article.
We previously identified in MDA-MB-435S cells, which preferentially use integrin alphaVbeta5 for adhesion, KANK2 as a key molecule enabling the actin-MT crosstalk. KANK2 knockdown also resulted in increased sensitivity to MT poisons, paclitaxel (PTX) and vincristine …
We previously identified in MDA-MB-435S cells, which preferentially use integrin alphaVbeta5 for adhesion, KANK2 as a key molecule en …
USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC.
Zheng J, Wu S, Tang M, Xi S, Wang Y, Ren J, Luo H, Hu P, Sun L, Du Y, Yang H, Wang F, Gao H, Dai Z, Ou X, Li Y. Zheng J, et al. Cell Death Dis. 2023 Oct 11;14(10):670. doi: 10.1038/s41419-023-06210-3. Cell Death Dis. 2023. PMID: 37821439 Free PMC article.
USP39 depletion deregulated hundreds of AS events, including the oncogenic splice-switching of KANK2. Mechanistically, we developed a novel RBP-motif enrichment analysis and found that USP39 modulated exon inclusion/exclusion by interacting with SRSF6/HNRNPC in both humans …
USP39 depletion deregulated hundreds of AS events, including the oncogenic splice-switching of KANK2. Mechanistically, we developed a …
Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
Guo Q, Liao S, Zhu Z, Li Y, Li F, Xu C. Guo Q, et al. J Biol Chem. 2018 Jan 12;293(2):557-566. doi: 10.1074/jbc.M117.817494. Epub 2017 Nov 28. J Biol Chem. 2018. PMID: 29183992 Free PMC article.
Here, using a combination of structural, site-directed mutagenesis, and biochemical studies, we found that a stretch of 22 amino acids in KIF21A is sufficient for binding to KANK1 and its close homolog KANK2. We further solved the complex structure of the KIF21A peptide wi …
Here, using a combination of structural, site-directed mutagenesis, and biochemical studies, we found that a stretch of 22 amino acids in KI …
KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
Gee HY, Zhang F, Ashraf S, Kohl S, Sadowski CE, Vega-Warner V, Zhou W, Lovric S, Fang H, Nettleton M, Zhu JY, Hoefele J, Weber LT, Podracka L, Boor A, Fehrenbach H, Innis JW, Washburn J, Levy S, Lifton RP, Otto EA, Han Z, Hildebrandt F. Gee HY, et al. J Clin Invest. 2015 Jun;125(6):2375-84. doi: 10.1172/JCI79504. Epub 2015 May 11. J Clin Invest. 2015. PMID: 25961457 Free PMC article.
Knockdown of kank2 in zebrafish recapitulated a nephrotic syndrome phenotype, resulting in proteinuria and podocyte foot process effacement. ...Knockdown of KANK2 in cultured podocytes increased active GTP-bound RHOA and decreased migration. ...
Knockdown of kank2 in zebrafish recapitulated a nephrotic syndrome phenotype, resulting in proteinuria and podocyte foot process effa …
Src in endosomal membranes promotes exosome secretion and tumor progression.
Hikita T, Kuwahara A, Watanabe R, Miyata M, Oneyama C. Hikita T, et al. Sci Rep. 2019 Mar 1;9(1):3265. doi: 10.1038/s41598-019-39882-z. Sci Rep. 2019. PMID: 30824759 Free PMC article.
Here we show that c-Src localized to the endosomal membrane has unique functions in c-Src-transformed cells. ...In addition, the ESCRT-interacting molecule, Alix was identified as a c-Src-interacting protein in exosomes. We revealed that the int …
Here we show that c-Src localized to the endosomal membrane has unique functions in c-Src-transformed cells. ...In addition, t …
Discovery and Characterization of Recurrent, Targetable ALK Fusions in Leiomyosarcoma.
Davis LE, Nusser KD, Przybyl J, Pittsenbarger J, Hofmann NE, Varma S, Vennam S, Debiec-Rychter M, van de Rijn M, Davare MA. Davis LE, et al. Mol Cancer Res. 2019 Mar;17(3):676-685. doi: 10.1158/1541-7786.MCR-18-1075. Epub 2018 Dec 5. Mol Cancer Res. 2019. PMID: 30518629
We identified ALK rearrangements in 9 of 377 (2.4%) patients with leiomyosarcoma, including a novel KANK2-ALK fusion and a recurrent ACTG2-ALK fusion. Functional characterization of the novel ALK fusion, KANK2-ALK, demonstrates it is a dominant oncogene in Ba/F3 or …
We identified ALK rearrangements in 9 of 377 (2.4%) patients with leiomyosarcoma, including a novel KANK2-ALK fusion and a recurrent …
Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy.
Min Y, Wang X, İş Ö, Patel TA, Gao J, Reddy JS, Quicksall ZS, Nguyen T, Lin S, Tutor-New FQ, Chalk JL, Mitchell AO, Crook JE, Nelson PT, Van Eldik LJ, Golde TE, Carrasquillo MM, Dickson DW, Zhang K, Allen M, Ertekin-Taner N. Min Y, et al. Nat Commun. 2023 Nov 2;14(1):6801. doi: 10.1038/s41467-023-42626-3. Nat Commun. 2023. PMID: 37919278 Free PMC article.
We discover, replicate, and annotate thousands of differentially expressed genes in PSP, many of which reside in glia-enriched co-expression modules and cells. We prioritize DDR2, STOM, and KANK2 as promising therapeutic targets in PSP with striking cross-species validatio …
We discover, replicate, and annotate thousands of differentially expressed genes in PSP, many of which reside in glia-enriched co-expression …
Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair.
Ramot Y, Molho-Pessach V, Meir T, Alper-Pinus R, Siam I, Tams S, Babay S, Zlotogorski A. Ramot Y, et al. J Med Genet. 2014 Jun;51(6):388-94. doi: 10.1136/jmedgenet-2014-102346. Epub 2014 Mar 26. J Med Genet. 2014. PMID: 24671081
METHODS AND RESULTS: Using whole-exome sequencing, we identified a homozygous missense c.2009C>T mutation in KANK2 in the patients (p.Ala670Val). KANK2 encodes the steroid receptor coactivator (SRC)-interacting protein (SIP), an ankyri …
METHODS AND RESULTS: Using whole-exome sequencing, we identified a homozygous missense c.2009C>T mutation in KANK2 in the patients …
SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
Zhang Y, Zhang H, Liang J, Yu W, Shang Y. Zhang Y, et al. EMBO J. 2007 Jun 6;26(11):2645-57. doi: 10.1038/sj.emboj.7601710. Epub 2007 May 3. EMBO J. 2007. PMID: 17476305 Free PMC article.
However, how these co-regulators are functionally regulated is poorly understood. During genome-wide screening for SRC-interacting proteins, we identified a novel ankyrin repeat containing protein, SIP (SRC-Interacting Protein), which interacts …
However, how these co-regulators are functionally regulated is poorly understood. During genome-wide screening for SRC-interacting pr …
24 results