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ETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2alpha/ATF4 Signaling.
Yang SY, Liao L, Hu SY, Deng L, Andriani L, Zhang TM, Zhang YL, Ma XY, Zhang FL, Liu YY, Li DQ. Yang SY, et al. Int J Mol Sci. 2023 Sep 26;24(19):14566. doi: 10.3390/ijms241914566. Int J Mol Sci. 2023. PMID: 37834012 Free PMC article.
Stable cell lines with ETHE1 overexpression or knockdown were constructed to explore the biological functions of ETHE1 during TNBC progression in vitro and in vivo. ...Notably, inhibition of eIF2alpha phosphorylation through ISRIB or ATF4 knockdown partially abolish …
Stable cell lines with ETHE1 overexpression or knockdown were constructed to explore the biological functions of ETHE1 during …
Ethylmalonic encephalopathy ETHE1 p. D165H mutation alters the mitochondrial function in human skeletal muscle proteome.
Sathe G, Deepha S, Gayathri N, Nagappa M, Parayil Sankaran B, Taly AB, Khanna T, Pandey A, Govindaraj P. Sathe G, et al. Mitochondrion. 2021 May;58:64-71. doi: 10.1016/j.mito.2021.02.011. Epub 2021 Feb 24. Mitochondrion. 2021. PMID: 33639274
Ethylmalonic encephalopathy (EE) is a rare autosomal recessive inborn error of metabolism. To study the molecular effects of ETHE1 p. D165H mutation, we employed mass spectrometry-based mitochondrial proteome and phosphoproteome profiling in the human skeletal muscle. ...
Ethylmalonic encephalopathy (EE) is a rare autosomal recessive inborn error of metabolism. To study the molecular effects of ETHE1 p. …
Ethylmalonic encephalopathy ETHE1 R163W/R163Q mutations alter protein stability and redox properties of the iron centre.
Henriques BJ, Lucas TG, Rodrigues JV, Frederiksen JH, Teixeira MS, Tiranti V, Bross P, Gomes CM. Henriques BJ, et al. PLoS One. 2014 Sep 8;9(9):e107157. doi: 10.1371/journal.pone.0107157. eCollection 2014. PLoS One. 2014. PMID: 25198162 Free PMC article.
Frequently mutations resulting in depletion of ETHE1 in patient cells are due to severe structural and folding defects. ...To address this issue and to elicit how ETHE1 dysfunction results in EE, we have investigated two such pathological mutations, ETHE1-p.A …
Frequently mutations resulting in depletion of ETHE1 in patient cells are due to severe structural and folding defects. ...To address …
Circulating Biomarkers and Risk of Hypertension: A Two-Sample Mendelian Randomisation Study.
Li J, Yao YX, Yao PS. Li J, et al. Heart Lung Circ. 2023 Dec;32(12):1434-1442. doi: 10.1016/j.hlc.2023.09.003. Epub 2023 Dec 1. Heart Lung Circ. 2023. PMID: 38042639 Free article.
SMOC1 and TIE1 were determined to be causative factors in the decreased likelihood of developing hypertension, with odds ratios of 0.86 (95% CI 0.81-0.91; p=1.06e-06) and 0.96 (95% CI 0.94-0.98; p=9.39e-05), respectively. NDUFB4, ETHE1, POFUT2, TRIL, ADAM23, GXYLT1, OXT, T …
SMOC1 and TIE1 were determined to be causative factors in the decreased likelihood of developing hypertension, with odds ratios of 0.86 (95% …
The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.
Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ. Pettinati I, et al. Trends Biochem Sci. 2016 Apr;41(4):338-355. doi: 10.1016/j.tibs.2015.12.007. Epub 2016 Jan 21. Trends Biochem Sci. 2016. PMID: 26805042 Free PMC article. Review.
Human (h)MBLf enzymes can bind metals, including zinc and iron ions, and catalyze a range of chemically interesting reactions, including both redox (e.g., ETHE1) and hydrolytic processes (e.g., Glyoxalase II, SNM1 nucleases, and CPSF73). ...
Human (h)MBLf enzymes can bind metals, including zinc and iron ions, and catalyze a range of chemically interesting reactions, including bot …
Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.
Pettinati I, Brem J, McDonough MA, Schofield CJ. Pettinati I, et al. Hum Mol Genet. 2015 May 1;24(9):2458-69. doi: 10.1093/hmg/ddv007. Epub 2015 Jan 16. Hum Mol Genet. 2015. PMID: 25596185 Free PMC article.
The ethylmalonic encephalopathy protein 1 (ETHE1) catalyses the oxygen-dependent oxidation of glutathione persulfide (GSSH) to give persulfite and glutathione. ...The active site of hETHE1 is very similar to an ETHE1-like enzyme from Arab …
The ethylmalonic encephalopathy protein 1 (ETHE1) catalyses the oxygen-dependent oxidation of glutathione …
Differential protein expression in metallothionein protection from depleted uranium-induced nephrotoxicity.
Hao Y, Huang J, Liu C, Li H, Liu J, Zeng Y, Yang Z, Li R. Hao Y, et al. Sci Rep. 2016 Dec 14;6:38942. doi: 10.1038/srep38942. Sci Rep. 2016. PMID: 27966587 Free PMC article.
The validating results showed that the expression of aminoacylase-3 (ACY-3) and the mitochondrial ethylmalonic encephalopathy 1 (ETHE1) decreased significantly after DU exposure; in addition, the reduction in MT-/- mice was more significant than that i …
The validating results showed that the expression of aminoacylase-3 (ACY-3) and the mitochondrial ethylmalonic encephalopathy …
Mitochondrial diseases caused by toxic compound accumulation: from etiopathology to therapeutic approaches.
Di Meo I, Lamperti C, Tiranti V. Di Meo I, et al. EMBO Mol Med. 2015 Oct;7(10):1257-66. doi: 10.15252/emmm.201505040. EMBO Mol Med. 2015. PMID: 26194912 Free PMC article. Review.
Here, we will review two peculiar mitochondrial disorders, ethylmalonic encephalopathy (EE) and mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), caused by mutations in the ETHE1 and TYMP nuclear genes, respectively. ETHE1 encodes for a mitochondrial en …
Here, we will review two peculiar mitochondrial disorders, ethylmalonic encephalopathy (EE) and mitochondrial neurogastrointestinal encephal …
Identification of a novel homozygous nonsense variant in a Chinese patient with ethylmalonic encephalopathy and a genotype-phenotype spectrum review.
Tao Y, Han D, Li X, Wang L, Yue L, Huang C, Lu D, Li X. Tao Y, et al. Clin Chim Acta. 2020 Oct;509:8-17. doi: 10.1016/j.cca.2020.05.051. Epub 2020 May 30. Clin Chim Acta. 2020. PMID: 32485156 Review.
Genetic testing identified a homozygous nonsense variant, c.295C > T (p. Q99*), in the ETHE1 gene. A review of all known ETHE1 variants observed in other EE patients was conducted. ...Besides, it also showed that patients with truncated variants of ETHE1 m …
Genetic testing identified a homozygous nonsense variant, c.295C > T (p. Q99*), in the ETHE1 gene. A review of all known ETHE1 …
Mechanism-based inhibition of human persulfide dioxygenase by γ-glutamyl-homocysteinyl-glycine.
Kabil O, Motl N, Strack M, Seravalli J, Metzler-Nolte N, Banerjee R. Kabil O, et al. J Biol Chem. 2018 Aug 10;293(32):12429-12439. doi: 10.1074/jbc.RA118.004096. Epub 2018 Jul 6. J Biol Chem. 2018. PMID: 29980601 Free PMC article.
However, its cellular concentration is strictly regulated to avoid toxicity. Persulfide dioxygenase (PDO or ETHE1) is a mononuclear non-heme iron-containing protein in the sulfide oxidation pathway catalyzing the conversion of GSH persulfide (GSSH) to sulfite and GSH. ...
However, its cellular concentration is strictly regulated to avoid toxicity. Persulfide dioxygenase (PDO or ETHE1) is a mononuclear n …
19 results