Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2020 14
2021 13
2022 14
2023 12
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

50 results

Results by year

Filters applied: . Clear all
Page 1
Extramedullary disease in multiple myeloma.
Bansal R, Rakshit S, Kumar S. Bansal R, et al. Blood Cancer J. 2021 Sep 29;11(9):161. doi: 10.1038/s41408-021-00527-y. Blood Cancer J. 2021. PMID: 34588423 Free PMC article. Review.
When clonal plasma cells grow at anatomic sites distant from the bone marrow or grows contiguous from osseous lesions that break through the cortical bone, it is referred to as extramedullary multiple myeloma (EMD). EMD remains challenging from a therapeutic and bio …
When clonal plasma cells grow at anatomic sites distant from the bone marrow or grows contiguous from osseous lesions that break through the …
Genetic Abnormalities in Extramedullary Multiple Myeloma.
McAvera R, Quinn J, Murphy P, Glavey S. McAvera R, et al. Int J Mol Sci. 2023 Jul 9;24(14):11259. doi: 10.3390/ijms241411259. Int J Mol Sci. 2023. PMID: 37511018 Free PMC article. Review.
Therefore, understanding the underlying mechanisms of bone marrow escape and EMD driver events is increasingly urgent. The role of genomics in MM has been studied extensively; however, much less is known about the genetic background of EMD. Recently there has been a …
Therefore, understanding the underlying mechanisms of bone marrow escape and EMD driver events is increasingly urgent. The role of ge …
Molecular Pathology of Laminopathies.
Shin JY, Worman HJ. Shin JY, et al. Annu Rev Pathol. 2022 Jan 24;17:159-180. doi: 10.1146/annurev-pathol-042220-034240. Epub 2021 Oct 21. Annu Rev Pathol. 2022. PMID: 34672689 Free PMC article. Review.
The Role of Emerin in Cancer Progression and Metastasis.
Liddane AG, Holaska JM. Liddane AG, et al. Int J Mol Sci. 2021 Oct 19;22(20):11289. doi: 10.3390/ijms222011289. Int J Mol Sci. 2021. PMID: 34681951 Free PMC article. Review.
A model is emerging whereby emerin, as well as other nuclear lamina proteins, binding to the nucleoskeleton regulates the nuclear structure to impact metastasis. In this model, emerin and lamins play a central role in metastatic transformation, since decreased em …
A model is emerging whereby emerin, as well as other nuclear lamina proteins, binding to the nucleoskeleton regulates the nuclear str …
Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression.
Li Mow Chee F, Beernaert B, Griffith BGC, Loftus AEP, Kumar Y, Wills JC, Lee M, Valli J, Wheeler AP, Armstrong JD, Parsons M, Leigh IM, Proby CM, von Kriegsheim A, Bickmore WA, Frame MC, Byron A. Li Mow Chee F, et al. Nat Commun. 2023 Mar 23;14(1):1602. doi: 10.1038/s41467-023-37021-x. Nat Commun. 2023. PMID: 36959177 Free PMC article.
CRISPR-mediated Mena depletion causes altered nuclear morphology, reduces tyrosine phosphorylation of the nuclear membrane protein emerin and downregulates expression of the immunomodulatory gene PTX3 via the recruitment of its enhancer to the nuclear periphery. ...
CRISPR-mediated Mena depletion causes altered nuclear morphology, reduces tyrosine phosphorylation of the nuclear membrane protein emerin …
Mechanistic Insights of the LEMD2 p.L13R Mutation and Its Role in Cardiomyopathy.
Chen R, Buchmann S, Kroth A, Arias-Loza AP, Kohlhaas M, Wagner N, Grüner G, Nickel A, Cirnu A, Williams T, Maack C, Ergün S, Frantz S, Gerull B. Chen R, et al. Circ Res. 2023 Jan 20;132(2):e43-e58. doi: 10.1161/CIRCRESAHA.122.321929. Epub 2023 Jan 4. Circ Res. 2023. PMID: 36656972 Free article.
Furthermore, increased DNA damage and premature senescence were detected as the underlying cause of fibrotic and inflammatory remodeling. As the p.L13R mutation is located in the Lap2/Emerin/Man1 (LEM)-domain, we observed a disrupted interaction between mutant LEMD2 and BA …
Furthermore, increased DNA damage and premature senescence were detected as the underlying cause of fibrotic and inflammatory remodeling. As …
Sinus node dysfunction and atrial fibrillation-Relationships, clinical phenotypes, new mechanisms, and treatment approaches.
Duan S, Du J. Duan S, et al. Ageing Res Rev. 2023 Apr;86:101890. doi: 10.1016/j.arr.2023.101890. Epub 2023 Feb 20. Ageing Res Rev. 2023. PMID: 36813137 Review.
Some genetic mutations can also cause arrhythmias, such as SCN5A, HCN4, EMD, and PITX2. The intrinsic cardiac autonomic nervous system (ICANS), a regulator of the heart's physiological functions, triggers arrhythmias.In addition, we discuss arrhythmias caused by viral infe …
Some genetic mutations can also cause arrhythmias, such as SCN5A, HCN4, EMD, and PITX2. The intrinsic cardiac autonomic nervous syste …
Identification of long noncoding RNA NEAT1 as a key gene involved in the extramedullary disease of multiple myeloma by bioinformatics analysis.
Chen T, Sun Z, Cui Y, Ji J, Li Y, Qu X. Chen T, et al. Hematology. 2023 Dec;28(1):2164449. doi: 10.1080/16078454.2022.2164449. Hematology. 2023. PMID: 36657019
To determine whether lncRNAs are involved in extramedullary disease of multiple myeloma (EMD), we analyzed the expression profile of lncRNAs in EMD. METHODS: Three pairs of EMD patients and their intramedullary MM cells were screened by microarray first. We e …
To determine whether lncRNAs are involved in extramedullary disease of multiple myeloma (EMD), we analyzed the expression profile of …
Combined sequence and copy number analysis improves diagnosis of limb girdle and other myopathies.
Nallamilli BRR, Pan Y, Sniderman King L, Jagannathan L, Ramachander V, Lucas A, Markind J, Colzani R, Hegde M. Nallamilli BRR, et al. Ann Clin Transl Neurol. 2023 Nov;10(11):2092-2104. doi: 10.1002/acn3.51896. Epub 2023 Sep 8. Ann Clin Transl Neurol. 2023. PMID: 37688281 Free PMC article.
Different sizes of copy number variants including single exon, multi-exon, and whole genes were identified in 7.5% (95) cases in genes including DMD, EMD, CAPN3, ANO5, SGCG, COL6A2, DOK7, and LAMA2. INTERPRETATION: "The Lantern Focused Neuromuscular Panel" enables identifi …
Different sizes of copy number variants including single exon, multi-exon, and whole genes were identified in 7.5% (95) cases in genes inclu …
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
Storey EC, Fuller HR. Storey EC, et al. Cells. 2022 Dec 15;11(24):4065. doi: 10.3390/cells11244065. Cells. 2022. PMID: 36552829 Free PMC article. Review.
Clusters of LMNA variants causing striated muscle disease are located in exons 1 and 6, and metabolic disease-associated LMNA variants are frequently found in the tail of lamin A/C. Additionally, exon 6 of the emerin gene, EMD, may be a mutation "hot-spot", and dise …
Clusters of LMNA variants causing striated muscle disease are located in exons 1 and 6, and metabolic disease-associated LMNA variants are f …
50 results