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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 4
2002 20
2003 47
2004 75
2005 112
2006 98
2007 176
2008 151
2009 214
2010 210
2011 178
2012 179
2013 172
2014 157
2015 123
2016 87
2017 108
2018 97
2019 93
2020 69
2021 45
2022 43
2023 48
2024 7

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2,386 results

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Page 1
Post-transcriptional control of miRNA biogenesis.
Michlewski G, Cáceres JF. Michlewski G, et al. RNA. 2019 Jan;25(1):1-16. doi: 10.1261/rna.068692.118. Epub 2018 Oct 17. RNA. 2019. PMID: 30333195 Free PMC article. Review.
MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary target mRNAs and repress their expression. ...Regulation of mature miRNA levels is critical in development, differentiation, and disease, as demonstrated by multiple levels of con …
MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary target mRNAs and repress their expression. ... …
Exploring the expanding universe of small RNAs.
Shi J, Zhou T, Chen Q. Shi J, et al. Nat Cell Biol. 2022 Apr;24(4):415-423. doi: 10.1038/s41556-022-00880-5. Epub 2022 Apr 12. Nat Cell Biol. 2022. PMID: 35414016 Free PMC article. Review.
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer structured RNAs (for example, transfer, ribosomal, Y, small nucleolar, small nucl …
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the r …
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.
Fabian MR, Sonenberg N. Fabian MR, et al. Nat Struct Mol Biol. 2012 Jun 5;19(6):586-93. doi: 10.1038/nsmb.2296. Nat Struct Mol Biol. 2012. PMID: 22664986 Review.
Since their discovery almost two decades ago, microRNAs (miRNAs) have been shown to function by post-transcriptionally regulating protein accumulation. ...However, the past few years have witnessed a quantum leap forward in our understanding of the molecular mechanics of …
Since their discovery almost two decades ago, microRNAs (miRNAs) have been shown to function by post-transcriptionally regulating pro …
Single-molecule imaging reveals translation-dependent destabilization of mRNAs.
Dave P, Roth G, Griesbach E, Mateju D, Hochstoeger T, Chao JA. Dave P, et al. Mol Cell. 2023 Feb 16;83(4):589-606.e6. doi: 10.1016/j.molcel.2023.01.013. Epub 2023 Feb 1. Mol Cell. 2023. PMID: 36731471 Free PMC article.
Furthermore, our results indicate that miRNAs mediate efficient degradation of both translating and non-translating target mRNAs and reveal a predominant role for mRNA degradation in miRNA-mediated regulation. Simultaneous observation of translation and decay of single mRN …
Furthermore, our results indicate that miRNAs mediate efficient degradation of both translating and non-translating target mRNAs and reveal …
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.
Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d'Onofrio M, Balasubramanian S, Kouzarides T. Pandolfini L, et al. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25. Mol Cell. 2019. PMID: 31031083 Free PMC article.
Using refined mass spectrometry methods, we map m7G to a single guanosine within the let-7e-5p miRNA. We show that METTL1-mediated methylation augments let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript …
Using refined mass spectrometry methods, we map m7G to a single guanosine within the let-7e-5p miRNA. We show that METTL1-mediated me …
Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.
Jones BT, Han J, Zhang H, Hammer RE, Evers BM, Rakheja D, Acharya A, Mendell JT. Jones BT, et al. Genes Dev. 2023 Jul 1;37(13-14):661-674. doi: 10.1101/gad.350906.123. Epub 2023 Aug 8. Genes Dev. 2023. PMID: 37553261 Free PMC article.
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway in which miRNAs that bind to specialized targets with extensive complementarity are rap …
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target …
Oncogenic K-Ras suppresses global miRNA function.
Shui B, Beyett TS, Chen Z, Li X, La Rocca G, Gazlay WM, Eck MJ, Lau KS, Ventura A, Haigis KM. Shui B, et al. Mol Cell. 2023 Jul 20;83(14):2509-2523.e13. doi: 10.1016/j.molcel.2023.06.008. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402366
Nevertheless, oncogenic K-Ras-induced dysregulation of post-transcriptional regulators such as microRNAs (miRNAs) during oncogenesis is poorly understood. Here, we report that K-Ras(G12D) promotes global suppression of miRNA activity, resulting in the upregulation o …
Nevertheless, oncogenic K-Ras-induced dysregulation of post-transcriptional regulators such as microRNAs (miRNAs) during oncogenesis …
Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P. Zapletal D, et al. Mol Cell. 2022 Nov 3;82(21):4064-4079.e13. doi: 10.1016/j.molcel.2022.10.010. Mol Cell. 2022. PMID: 36332606 Free PMC article.
MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating miRNA pathway, but how it is specifically adapted to miRNA biogenesis is unknown. …
MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by Dicer endonucleases. Mammalian Dicer prim …
Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB.
Jouravleva K, Golovenko D, Demo G, Dutcher RC, Hall TMT, Zamore PD, Korostelev AA. Jouravleva K, et al. Mol Cell. 2022 Nov 3;82(21):4049-4063.e6. doi: 10.1016/j.molcel.2022.09.002. Epub 2022 Sep 30. Mol Cell. 2022. PMID: 36182693 Free PMC article.
In animals and plants, Dicer enzymes collaborate with double-stranded RNA-binding domain (dsRBD) proteins to convert precursor-microRNAs (pre-miRNAs) into miRNA duplexes. We report six cryo-EM structures of Drosophila Dicer-1 that show how Dicer-1 and its partner Lo …
In animals and plants, Dicer enzymes collaborate with double-stranded RNA-binding domain (dsRBD) proteins to convert precursor-microRNAs …
2,386 results