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Spike-Independent Infection of Human Coronavirus 229E in Bat Cells.
Mah MG, Linster M, Low DHW, Zhuang Y, Jayakumar J, Samsudin F, Wong FY, Bond PJ, Mendenhall IH, Su YCF, Smith GJD. Mah MG, et al. Microbiol Spectr. 2023 Jun 15;11(3):e0348322. doi: 10.1128/spectrum.03483-22. Epub 2023 May 18. Microbiol Spectr. 2023. PMID: 37199653 Free PMC article.
After passaging this isolate in human cells, spike expression was restored due to acquisition of nucleotide insertions among virus subpopulations. Spike-independent infection of human coronavirus 229E may provide an alternative mechanism for viral maintenance …
After passaging this isolate in human cells, spike expression was restored due to acquisition of nucleotide insertions among virus subpopula …
Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins.
Lau SKP, Fan RYY, Luk HKH, Zhu L, Fung J, Li KSM, Wong EYM, Ahmed SS, Chan JFW, Kok RKH, Chan KH, Wernery U, Yuen KY, Woo PCY. Lau SKP, et al. Emerg Microbes Infect. 2018 Dec 10;7(1):209. doi: 10.1038/s41426-018-0208-9. Emerg Microbes Infect. 2018. PMID: 30531999 Free PMC article.
We developed 12 primary bat cell lines from seven bat species, including Tylonycteris pachypus, Pipistrellus abramus and Rhinolophus sinicus (hosts of Tylonycteris-BatCoV HKU4, Pipistrellus-BatCoV HKU5, and SARS-related-CoV respectively), and tested their susceptibilities …
We developed 12 primary bat cell lines from seven bat species, including Tylonycteris pachypus, Pipistrellus abramus and Rhinolophus …