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Results: 1 to 20 of 56

1.

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.

Zíma V, Witschas K, Hynkova A, Zímová L, Barvík I, Vlachova V.

Neuropharmacology. 2015 Jun;93:294-307. doi: 10.1016/j.neuropharm.2015.02.018. Epub 2015 Feb 25.

PMID:
25724085
2.

Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane.

Witschas K, Jobin ML, Korkut DN, Vladan MM, Salgado G, Lecomte S, Vlachova V, Alves ID.

Biochim Biophys Acta. 2015 May;1848(5):1147-56. doi: 10.1016/j.bbamem.2015.02.003. Epub 2015 Feb 14.

PMID:
25687973
3.

Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?

Boukalova S, Touska F, Marsakova L, Hynkova A, Sura L, Chvojka S, Dittert I, Vlachova V.

Physiol Res. 2014;63 Suppl 1:S205-13. Review. Erratum in: Physiol Res. 2014;63(5):667.

4.

Amplified cold transduction in native nociceptors by M-channel inhibition.

Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, Vlachova V, Reeh PW, Zimmermann K.

J Neurosci. 2013 Oct 16;33(42):16627-41. doi: 10.1523/JNEUROSCI.1473-13.2013.

5.

Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel.

Boukalova S, Teisinger J, Vlachova V.

Biochim Biophys Acta. 2013 Mar;1833(3):520-8. doi: 10.1016/j.bbamcr.2012.11.017. Epub 2012 Dec 4.

6.

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.

Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachová V, Reeh PW, Lewis RJ, Zimmermann K.

EMBO J. 2012 Oct 3;31(19):3795-808. doi: 10.1038/emboj.2012.207. Epub 2012 Jul 31.

7.

C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel.

Sura L, Zíma V, Marsakova L, Hynkova A, Barvík I, Vlachova V.

J Biol Chem. 2012 May 25;287(22):18067-77. doi: 10.1074/jbc.M112.341859. Epub 2012 Mar 29.

8.

Pore helix domain is critical to camphor sensitivity of transient receptor potential vanilloid 1 channel.

Marsakova L, Touska F, Krusek J, Vlachova V.

Anesthesiology. 2012 Apr;116(4):903-17. doi: 10.1097/ALN.0b013e318249cf62.

PMID:
22314297
9.

TRP channels: from understanding to action.

Vlachova V.

Curr Pharm Biotechnol. 2011 Jan 1;12(1):1-2. No abstract available.

PMID:
21244360
10.

Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels.

Boukalova S, Marsakova L, Teisinger J, Vlachova V.

J Biol Chem. 2010 Dec 31;285(53):41455-62. doi: 10.1074/jbc.M110.145466. Epub 2010 Nov 2.

11.

The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.

Samad A, Sura L, Benedikt J, Ettrich R, Minofar B, Teisinger J, Vlachova V.

Biochem J. 2011 Jan 1;433(1):197-204. doi: 10.1042/BJ20101256.

12.

A "cute" desensitization of TRPV1.

Touska F, Marsakova L, Teisinger J, Vlachova V.

Curr Pharm Biotechnol. 2011 Jan 1;12(1):122-9. Review.

PMID:
20932251
13.

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.

Benedikt J, Samad A, Ettrich R, Teisinger J, Vlachova V.

Biochim Biophys Acta. 2009 Jul;1793(7):1279-88. doi: 10.1016/j.bbamcr.2009.04.014. Epub 2009 May 5.

14.

Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin.

Vyklický L, Nováková-Tousová K, Benedikt J, Samad A, Touska F, Vlachová V.

Physiol Res. 2008;57 Suppl 3:S59-68. Epub 2008 May 13.

15.

Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.

Novakova-Tousova K, Vyklicky L, Susankova K, Benedikt J, Samad A, Teisinger J, Vlachova V.

Neuroscience. 2007 Oct 12;149(1):144-54. Epub 2007 Aug 8.

PMID:
17869438
16.

ATP binding site on the C-terminus of the vanilloid receptor.

Grycova L, Lansky Z, Friedlova E, Vlachova V, Kubala M, Obsilova V, Obsil T, Teisinger J.

Arch Biochem Biophys. 2007 Sep 15;465(2):389-98. Epub 2007 Jul 21.

PMID:
17706589
17.

Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1).

Susankova K, Ettrich R, Vyklicky L, Teisinger J, Vlachova V.

J Neurosci. 2007 Jul 11;27(28):7578-85.

18.

Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate.

Benedikt J, Teisinger J, Vyklicky L, Vlachova V.

J Neurochem. 2007 Jan;100(1):211-24. Epub 2006 Oct 27.

PMID:
17074062
19.

Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.

Susankova K, Tousova K, Vyklicky L, Teisinger J, Vlachova V.

Mol Pharmacol. 2006 Jul;70(1):383-94. Epub 2006 Apr 13.

20.

Improved superfusion technique for rapid cooling or heating of cultured cells under patch-clamp conditions.

Dittert I, Benedikt J, Vyklický L, Zimmermann K, Reeh PW, Vlachová V.

J Neurosci Methods. 2006 Mar 15;151(2):178-85. Epub 2005 Aug 29.

PMID:
16129494
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