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Results: 1 to 20 of 95

1.

Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.

Tesio M, Tang Y, Müdder K, Saini M, von Paleske L, Macintyre E, Pasparakis M, Waisman A, Trumpp A.

J Exp Med. 2015 Apr 6;212(4):525-38. doi: 10.1084/jem.20141438. Epub 2015 Mar 30.

PMID:
25824820
2.

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging.

Vick B, Rothenberg M, Sandhöfer N, Carlet M, Finkenzeller C, Krupka C, Grunert M, Trumpp A, Corbacioglu S, Ebinger M, André MC, Hiddemann W, Schneider S, Subklewe M, Metzeler KH, Spiekermann K, Jeremias I.

PLoS One. 2015 Mar 20;10(3):e0120925. doi: 10.1371/journal.pone.0120925. eCollection 2015.

3.

Suppression of Early Hematogenous Dissemination of Human Breast Cancer Cells to Bone Marrow by Retinoic Acid-Induced 2.

Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefström J, Wilmanns M, Müller V, Pantel K, Wikman H.

Cancer Discov. 2015 Feb 25. [Epub ahead of print]

PMID:
25716347
4.

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD.

Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131. Epub 2015 Feb 18.

PMID:
25707806
5.

Defined conditions for the isolation and expansion of Basal prostate progenitor cells of mouse and human origin.

Höfner T, Eisen C, Klein C, Rigo-Watermeier T, Goeppinger SM, Jauch A, Schoell B, Vogel V, Noll E, Weichert W, Baccelli I, Schillert A, Wagner S, Pahernik S, Sprick MR, Trumpp A.

Stem Cell Reports. 2015 Mar 10;4(3):503-18. doi: 10.1016/j.stemcr.2015.01.015. Epub 2015 Feb 19.

6.

CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.

Teodorczyk M, Kleber S, Wollny D, Sefrin JP, Aykut B, Mateos A, Herhaus P, Sancho-Martinez I, Hill O, Gieffers C, Sykora J, Weichert W, Eisen C, Trumpp A, Sprick MR, Bergmann F, Welsch T, Martin-Villalba A.

Cell Death Differ. 2015 Jan 23. doi: 10.1038/cdd.2014.217. [Epub ahead of print]

PMID:
25613377
7.

The rarity of ALDH+ cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients.

Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C.

Int J Cancer. 2014 Dec 26. doi: 10.1002/ijc.29410. [Epub ahead of print]

PMID:
25545165
8.

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.

Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C.

Cell Cycle. 2014;13(22):3476-87. doi: 10.4161/15384101.2014.973334.

PMID:
25483069
9.

Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment.

Klimmeck D, Cabezas-Wallscheid N, Reyes A, von Paleske L, Renders S, Hansson J, Krijgsveld J, Huber W, Trumpp A.

Stem Cell Reports. 2014 Nov 11;3(5):858-75. doi: 10.1016/j.stemcr.2014.08.012. Epub 2014 Sep 25.

10.

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients.

Baccelli I, Stenzinger A, Vogel V, Pfitzner BM, Klein C, Wallwiener M, Scharpff M, Saini M, Holland-Letz T, Sinn HP, Schneeweiss A, Denkert C, Weichert W, Trumpp A.

Oncotarget. 2014 Sep 30;5(18):8147-60.

11.

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome analysis.

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A.

Cell Stem Cell. 2014 Oct 2;15(4):507-22. doi: 10.1016/j.stem.2014.07.005. Epub 2014 Aug 21.

PMID:
25158935
12.

Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients.

Wallwiener M, Riethdorf S, Hartkopf AD, Modugno C, Nees J, Madhavan D, Sprick MR, Schott S, Domschke C, Baccelli I, Schönfisch B, Burwinkel B, Marmé F, Heil J, Sohn C, Pantel K, Trumpp A, Schneeweiss A.

BMC Cancer. 2014 Jul 11;14:512. doi: 10.1186/1471-2407-14-512.

13.

Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis.

Madhavan D, Wallwiener M, Bents K, Zucknick M, Nees J, Schott S, Cuk K, Riethdorf S, Trumpp A, Pantel K, Sohn C, Schneeweiss A, Surowy H, Burwinkel B.

Breast Cancer Res Treat. 2014 Jul;146(1):163-74. doi: 10.1007/s10549-014-2946-2. Epub 2014 May 17.

PMID:
24838941
14.

Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence.

Ehninger A, Boch T, Medyouf H, Müdder K, Orend G, Trumpp A.

Blood. 2014 Jun 26;123(26):4054-63. doi: 10.1182/blood-2013-10-533711. Epub 2014 May 15.

PMID:
24833352
15.

Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α-induced stress response.

Ehninger A, Boch T, Uckelmann H, Essers MA, Müdder K, Sleckman BP, Trumpp A.

Blood. 2014 Jun 19;123(25):3909-13. doi: 10.1182/blood-2013-10-531038. Epub 2014 May 2.

PMID:
24795346
16.

Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.

Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jöckel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, Trumpp A.

J Exp Med. 2014 May 5;211(5):769-79. doi: 10.1084/jem.20131072. Epub 2014 Apr 21.

17.

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.

Medyouf H, Mossner M, Jann JC, Nolte F, Raffel S, Herrmann C, Lier A, Eisen C, Nowak V, Zens B, Müdder K, Klein C, Obländer J, Fey S, Vogler J, Fabarius A, Riedl E, Roehl H, Kohlmann A, Staller M, Haferlach C, Müller N, John T, Platzbecker U, Metzgeroth G, Hofmann WK, Trumpp A, Nowak D.

Cell Stem Cell. 2014 Jun 5;14(6):824-37. doi: 10.1016/j.stem.2014.02.014. Epub 2014 Apr 3.

PMID:
24704494
18.

Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.

Hofner T, Macher-Goeppinger S, Klein C, Schillert A, Eisen C, Wagner S, Rigo-Watermeier T, Baccelli I, Vogel V, Trumpp A, Sprick MR.

Urol Oncol. 2014 Jul;32(5):678-86. doi: 10.1016/j.urolonc.2014.01.001. Epub 2014 Mar 12.

PMID:
24631171
19.

The impact of type 2 diabetes on the outcome of localized renal cell carcinoma.

Höfner T, Zeier M, Hatiboglu G, Eisen C, Schönberg G, Hadaschik B, Teber D, Duensing S, Trumpp A, Hohenfellner M, Pahernik S.

World J Urol. 2014 Dec;32(6):1537-42. doi: 10.1007/s00345-013-1231-z. Epub 2013 Dec 27.

PMID:
24370691
20.

Hypermutation of the inactive X chromosome is a frequent event in cancer.

Jäger N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, Eils R.

Cell. 2013 Oct 24;155(3):567-81. doi: 10.1016/j.cell.2013.09.042. Epub 2013 Oct 17.

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