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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 3
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2005 7
2006 7
2007 5
2008 12
2009 12
2010 9
2011 9
2012 8
2013 11
2014 18
2015 12
2016 13
2017 17
2018 18
2019 15
2020 13
2021 16
2022 4
2023 3
2024 0

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187 results

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Page 1
A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy.
Upadhyay R, Boiarsky JA, Pantsulaia G, Svensson-Arvelund J, Lin MJ, Wroblewska A, Bhalla S, Scholler N, Bot A, Rossi JM, Sadek N, Parekh S, Lagana A, Baccarini A, Merad M, Brown BD, Brody JD. Upadhyay R, et al. Cancer Discov. 2021 Mar;11(3):599-613. doi: 10.1158/2159-8290.CD-20-0756. Epub 2020 Dec 17. Cancer Discov. 2021. PMID: 33334730 Free PMC article.
Fas-mediated on-target and bystander killing was reproduced in chimeric antigen receptor (CAR-T) and bispecific antibody T-cell models and was augmented by inhibiting regulators of Fas signaling. Tumoral FAS expression alone predicted survival of CAR-T-treated patients in …
Fas-mediated on-target and bystander killing was reproduced in chimeric antigen receptor (CAR-T) and bispecific antibody T-cell models and w …
Can we predict T cell specificity with digital biology and machine learning?
Hudson D, Fernandes RA, Basham M, Ogg G, Koohy H. Hudson D, et al. Nat Rev Immunol. 2023 Aug;23(8):511-521. doi: 10.1038/s41577-023-00835-3. Epub 2023 Feb 8. Nat Rev Immunol. 2023. PMID: 36755161 Free PMC article. Review.
Current data sets are limited to a negligible fraction of the universe of possible TCR-ligand pairs, and performance of state-of-the-art predictive models wanes when applied beyond these known binders. In this Perspective article, we make the case for renewed and coordinat …
Current data sets are limited to a negligible fraction of the universe of possible TCR-ligand pairs, and performance of state-of-the-art …
T Cell Epitope Prediction and Its Application to Immunotherapy.
Schaap-Johansen AL, Vujović M, Borch A, Hadrup SR, Marcatili P. Schaap-Johansen AL, et al. Front Immunol. 2021 Sep 15;12:712488. doi: 10.3389/fimmu.2021.712488. eCollection 2021. Front Immunol. 2021. PMID: 34603286 Free PMC article. Review.
In this review, we focus on the currently available computational tools for epitope prediction, with a particular focus on tools aimed at identifying neoepitopes, i.e. cancer-specific peptides and their potential for use in immunotherapy for cancer treatment. ...
In this review, we focus on the currently available computational tools for epitope prediction, with a particular focus on tools aime …
Specificity of the T Cell Response to Protein Biopharmaceuticals.
Meunier S, de Bourayne M, Hamze M, Azam A, Correia E, Menier C, Maillère B. Meunier S, et al. Front Immunol. 2020 Jul 22;11:1550. doi: 10.3389/fimmu.2020.01550. eCollection 2020. Front Immunol. 2020. PMID: 32793213 Free PMC article. Review.
BP-specific T cell responses are assessed in healthy subjects to anticipate the immunogenicity of BP prior to their testing in clinical trials. Immunogenicity prediction, also called preclinical immunogenicity assessment, aims at identifying immunogenic BPs and immunogenic …
BP-specific T cell responses are assessed in healthy subjects to anticipate the immunogenicity of BP prior to their testing in clinical tria …
CD44v6 chimeric antigen receptor T cell specificity towards AML with FLT3 or DNMT3A mutations.
Tang L, Huang H, Tang Y, Li Q, Wang J, Li D, Zhong Z, Zou P, You Y, Cao Y, Kong Y, Guo A, Zhou S, Li H, Meng F, Xiao Y, Zhu X. Tang L, et al. Clin Transl Med. 2022 Sep;12(9):e1043. doi: 10.1002/ctm2.1043. Clin Transl Med. 2022. PMID: 36163632 Free PMC article.
Then we constructed CD44v6 CAR-T cells and found that CD44v6 CAR-T specifically lysed CD44v6(+) cells, accompanied by cytokines release. No significant killing effect was observed from CD44v6(-) AML cells and normal cells after co-culture with CD44v6 CAR-T. These results w …
Then we constructed CD44v6 CAR-T cells and found that CD44v6 CAR-T specifically lysed CD44v6(+) cells, accompanied by cytokines release. No …
Cell therapies for hematological malignancies: don't forget non-gene-modified t cells!
Grant ML, Bollard CM. Grant ML, et al. Blood Rev. 2018 May;32(3):203-224. doi: 10.1016/j.blre.2017.11.004. Epub 2017 Nov 27. Blood Rev. 2018. PMID: 29198753 Free PMC article. Review.
For hematologic malignancies, cell therapy is contributing to enhanced clinical responses and overall survival and the immune response to cell therapy is predictive of response in multiple cancer types. In this review we summarize the available T cell therapeutics that do …
For hematologic malignancies, cell therapy is contributing to enhanced clinical responses and overall survival and the immune response to ce …
TITAN: T-cell receptor specificity prediction with bimodal attention networks.
Weber A, Born J, Rodriguez Martínez M. Weber A, et al. Bioinformatics. 2021 Jul 12;37(Suppl_1):i237-i244. doi: 10.1093/bioinformatics/btab294. Bioinformatics. 2021. PMID: 34252922 Free PMC article.
RESULTS: By encoding epitopes at the atomic level with SMILES sequences, we leverage transfer learning and data augmentation to enrich the input data space and boost performance. TITAN achieves high performance in the prediction of specificity of unseen TCRs (ROC-AUC 0.87 …
RESULTS: By encoding epitopes at the atomic level with SMILES sequences, we leverage transfer learning and data augmentation to enrich the i …
In-depth analysis of human virus-specific CD8(+) T cells delineates unique phenotypic signatures for T cell specificity prediction.
Schmidt F, Fields HF, Purwanti Y, Milojkovic A, Salim S, Wu KX, Simoni Y, Vitiello A, MacLeod DT, Nardin A, Newell EW, Fink K, Wilm A, Fehlings M. Schmidt F, et al. Cell Rep. 2023 Oct 31;42(10):113250. doi: 10.1016/j.celrep.2023.113250. Epub 2023 Oct 12. Cell Rep. 2023. PMID: 37837618 Free article.
We analyze over 500 antigen-specific T cell responses across six different HLA alleles and observed unique phenotypes of T cells specific for antigens from different virus categories. Using machine learning, we extract phenotypic signatures of antigen-specific T cells, …
We analyze over 500 antigen-specific T cell responses across six different HLA alleles and observed unique phenotypes of T cells spec …
T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis.
Cruciani C, Puthenparampil M, Tomas-Ojer P, Jelcic I, Docampo MJ, Planas R, Manogaran P, Opfer R, Wicki C, Reindl M, Jelcic I, Lutterotti A, Martin R, Sospedra M. Cruciani C, et al. Neurol Neuroimmunol Neuroinflamm. 2021 Sep 17;8(6):e1075. doi: 10.1212/NXI.0000000000001075. Print 2021 Nov. Neurol Neuroimmunol Neuroinflamm. 2021. PMID: 34535569 Free PMC article.
Patients with different intrathecal T-cell specificities also differ regarding inflammation- and neurodegeneration-associated biomarkers, imaging findings, expression of HLA class II alleles, and seasonal distribution of the time of the lumbar puncture. DISCUSSION: Our observa …
Patients with different intrathecal T-cell specificities also differ regarding inflammation- and neurodegeneration-associated biomarkers, im …
Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism.
Baker BM, Scott DR, Blevins SJ, Hawse WF. Baker BM, et al. Immunol Rev. 2012 Nov;250(1):10-31. doi: 10.1111/j.1600-065X.2012.01165.x. Immunol Rev. 2012. PMID: 23046120 Review.
Here we review and contextualize our contributions, which have emphasized the influence of structural changes and molecular flexibility. A repeated observation is the presence of conformational melding, in which the T-cell receptor (TCR), peptide, and in some cases, MHC pr …
Here we review and contextualize our contributions, which have emphasized the influence of structural changes and molecular flexibility. A r …
187 results