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Results: 1 to 20 of 23

1.

Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.

Maciejewski BS, LaPerle JL, Chen D, Ghosh A, Zavadoski WJ, McDonald TS, Manion TB, Mather D, Patterson TA, Hanna M, Watkins S, Gibbs EM, Calle RA, Steppan CM.

Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G958-69. doi: 10.1152/ajpgi.00384.2012. Epub 2013 Apr 4.

2.

Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.

Ryder T, Walker GS, Goosen TC, Ruggeri RB, Conn EL, Rocke BN, Lapham K, Steppan CM, Hepworth D, Kalgutkar AS.

Chem Res Toxicol. 2012 Oct 15;25(10):2138-52. doi: 10.1021/tx300243v. Epub 2012 Sep 27.

PMID:
22989032
3.

Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform.

Enayetallah AE, Ziemek D, Leininger MT, Randhawa R, Yang J, Manion TB, Mather DE, Zavadoski WJ, Kuhn M, Treadway JL, des Etages SA, Gibbs EM, Greene N, Steppan CM.

PLoS One. 2011;6(11):e27009. doi: 10.1371/journal.pone.0027009. Epub 2011 Nov 4.

4.

Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors.

Mascitti V, Maurer TS, Robinson RP, Bian J, Boustany-Kari CM, Brandt T, Collman BM, Kalgutkar AS, Klenotic MK, Leininger MT, Lowe A, Maguire RJ, Masterson VM, Miao Z, Mukaiyama E, Patel JD, Pettersen JC, Préville C, Samas B, She L, Sobol Z, Steppan CM, Stevens BD, Thuma BA, Tugnait M, Zeng D, Zhu T.

J Med Chem. 2011 Apr 28;54(8):2952-60. doi: 10.1021/jm200049r. Epub 2011 Mar 30.

PMID:
21449606
5.

N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors.

Atkinson KA, Beretta EE, Brown JA, Castrodad M, Chen Y, Cosgrove JM, Du P, Litchfield J, Makowski M, Martin K, McLellan TJ, Neagu C, Perry DA, Piotrowski DW, Steppan CM, Trilles R.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1621-5. doi: 10.1016/j.bmcl.2011.01.113. Epub 2011 Jan 31.

PMID:
21324691
6.

C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization.

Robinson RP, Mascitti V, Boustany-Kari CM, Carr CL, Foley PM, Kimoto E, Leininger MT, Lowe A, Klenotic MK, Macdonald JI, Maguire RJ, Masterson VM, Maurer TS, Miao Z, Patel JD, Préville C, Reese MR, She L, Steppan CM, Thuma BA, Zhu T.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1569-72. doi: 10.1016/j.bmcl.2010.01.075. Epub 2010 Jan 21.

PMID:
20149653
7.

HIV protease inhibitor-specific alterations in human adipocyte differentiation and metabolism.

Kim RJ, Wilson CG, Wabitsch M, Lazar MA, Steppan CM.

Obesity (Silver Spring). 2006 Jun;14(6):994-1002.

PMID:
16861604
8.

Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.

Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Lazar MA, Abel ED.

J Biol Chem. 2005 Sep 9;280(36):31679-85. Epub 2005 Jun 27.

9.

Activation of SOCS-3 by resistin.

Steppan CM, Wang J, Whiteman EL, Birnbaum MJ, Lazar MA.

Mol Cell Biol. 2005 Feb;25(4):1569-75.

10.

The current biology of resistin.

Steppan CM, Lazar MA.

J Intern Med. 2004 Apr;255(4):439-47. Review.

PMID:
15049878
11.

Regulation of fasted blood glucose by resistin.

Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA.

Science. 2004 Feb 20;303(5661):1195-8.

12.

Bacterial colonization leads to the colonic secretion of RELMbeta/FIZZ2, a novel goblet cell-specific protein.

He W, Wang ML, Jiang HQ, Steppan CM, Shin ME, Thurnheer MC, Cebra JJ, Lazar MA, Wu GD.

Gastroenterology. 2003 Nov;125(5):1388-97.

PMID:
14598255
13.

Variation in resistin gene promoter not associated with polycystic ovary syndrome.

Urbanek M, Du Y, Silander K, Collins FS, Steppan CM, Strauss JF 3rd, Dunaif A, Spielman RS, Legro RS.

Diabetes. 2003 Jan;52(1):214-7.

14.

A futile metabolic cycle activated in adipocytes by antidiabetic agents.

Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA.

Nat Med. 2002 Oct;8(10):1122-8. Epub 2002 Sep 23.

PMID:
12357248
15.

Resistin and obesity-associated insulin resistance.

Steppan CM, Lazar MA.

Trends Endocrinol Metab. 2002 Jan-Feb;13(1):18-23. Review.

PMID:
11750858
16.

Abdominal fat distribution in pre- and postmenopausal women: The impact of physical activity, age, and menopausal status.

Kanaley JA, Sames C, Swisher L, Swick AG, Ploutz-Snyder LL, Steppan CM, Sagendorf KS, Feiglin D, Jaynes EB, Meyer RA, Weinstock RS.

Metabolism. 2001 Aug;50(8):976-82.

PMID:
11474488
17.

Altered expression of C/EBP family members results in decreased adipogenesis with aging.

Karagiannides I, Tchkonia T, Dobson DE, Steppan CM, Cummins P, Chan G, Salvatori K, Hadzopoulou-Cladaras M, Kirkland JL.

Am J Physiol Regul Integr Comp Physiol. 2001 Jun;280(6):R1772-80.

18.

The hormone resistin links obesity to diabetes.

Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA.

Nature. 2001 Jan 18;409(6818):307-12.

PMID:
11201732
19.

A family of tissue-specific resistin-like molecules.

Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, Enders GH, Silberg DG, Wen X, Wu GD, Lazar MA.

Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):502-6.

20.

Leptin is a potent stimulator of bone growth in ob/ob mice.

Steppan CM, Crawford DT, Chidsey-Frink KL, Ke H, Swick AG.

Regul Pept. 2000 Aug 25;92(1-3):73-8.

PMID:
11024568
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