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Results: 1 to 20 of 37

1.

Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-trans retinaldehyde-In Vitro Studies and Computational Modeling.

Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V.

Pharm Res. 2014 Nov 21. [Epub ahead of print]

PMID:
25413692
[PubMed - as supplied by publisher]
2.

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.

Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R.

J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22.

PMID:
24755226
[PubMed - indexed for MEDLINE]
3.

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma.

Harris PS, Venkataraman S, Alimova I, Birks DK, Balakrishnan I, Cristiano B, Donson AM, Dubuc AM, Taylor MD, Foreman NK, Reigan P, Vibhakar R.

Mol Cancer. 2014 Mar 24;13:72. doi: 10.1186/1476-4598-13-72.

PMID:
24661910
[PubMed - in process]
Free PMC Article
4.

Inhibition of Wee1 sensitizes cancer cells to antimetabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality.

Van Linden AA, Baturin D, Ford JB, Fosmire SP, Gardner L, Korch C, Reigan P, Porter CC.

Mol Cancer Ther. 2013 Dec;12(12):2675-84. doi: 10.1158/1535-7163.MCT-13-0424. Epub 2013 Oct 11.

PMID:
24121103
[PubMed - indexed for MEDLINE]
5.

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR.

Free Radic Biol Med. 2013 Dec;65:680-92. doi: 10.1016/j.freeradbiomed.2013.07.011. Epub 2013 Jul 17.

PMID:
23872024
[PubMed - in process]
6.

Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.

Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P.

Neurochem Res. 2013 Sep;38(9):1838-49. doi: 10.1007/s11064-013-1090-4. Epub 2013 Jun 7.

PMID:
23743623
[PubMed - indexed for MEDLINE]
7.

Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation.

Sun AQ, Luo Y, Backos DS, Xu S, Balasubramaniyan N, Reigan P, Suchy FJ.

Mol Pharmacol. 2013 May;83(5):1078-86. doi: 10.1124/mol.113.084772. Epub 2013 Mar 5.

PMID:
23462506
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.

Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC.

Chem Biol Interact. 2013 Feb 25;202(1-3):22-31. doi: 10.1016/j.cbi.2012.12.018. Epub 2013 Jan 21.

PMID:
23348497
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.

Jackson BC, Holmes RS, Backos DS, Reigan P, Thompson DC, Vasiliou V.

Chem Biol Interact. 2013 Feb 25;202(1-3):11-21. doi: 10.1016/j.cbi.2012.11.022. Epub 2012 Dec 13.

PMID:
23247008
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis.

Ryan K, Backos DS, Reigan P, Patel M.

J Neurosci. 2012 Aug 15;32(33):11250-8. doi: 10.1523/JNEUROSCI.0907-12.2012.

PMID:
22895709
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle.

Sarsour EH, Kalen AL, Xiao Z, Veenstra TD, Chaudhuri L, Venkataraman S, Reigan P, Buettner GR, Goswami PC.

Cancer Res. 2012 Aug 1;72(15):3807-16. doi: 10.1158/0008-5472.CAN-11-1063. Epub 2012 Jun 18.

PMID:
22710435
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.

Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR.

PLoS One. 2012;7(6):e38459. doi: 10.1371/journal.pone.0038459. Epub 2012 Jun 6.

PMID:
22701647
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells.

Shearn CT, Reigan P, Petersen DR.

Free Radic Biol Med. 2012 Jul 1;53(1):1-11. doi: 10.1016/j.freeradbiomed.2012.04.021. Epub 2012 May 1.

PMID:
22580126
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Neoamphimedine circumvents metnase-enhanced DNA topoisomerase II╬▒ activity through ATP-competitive inhibition.

Ponder J, Yoo BH, Abraham AD, Li Q, Ashley AK, Amerin CL, Zhou Q, Reid BG, Reigan P, Hromas R, Nickoloff JA, LaBarbera DV.

Mar Drugs. 2011;9(11):2397-408. doi: 10.3390/md9112397. Epub 2011 Nov 18.

PMID:
22163192
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The role of glutathione in brain tumor drug resistance.

Backos DS, Franklin CC, Reigan P.

Biochem Pharmacol. 2012 Apr 15;83(8):1005-12. doi: 10.1016/j.bcp.2011.11.016. Epub 2011 Nov 28. Review.

PMID:
22138445
[PubMed - indexed for MEDLINE]
16.

Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.

Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D.

Biochemistry. 2011 Aug 9;50(31):6678-88. doi: 10.1021/bi2002967. Epub 2011 Jul 19.

PMID:
21718050
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Determinants of adipophilin function in milk lipid formation and secretion.

Chong BM, Reigan P, Mayle-Combs KD, Orlicky DJ, McManaman JL.

Trends Endocrinol Metab. 2011 Jun;22(6):211-7. doi: 10.1016/j.tem.2011.04.003. Epub 2011 May 17. Review.

PMID:
21592818
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.

Dufour M, Yan C, Siegel D, Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Li Y, De Matteis CI, Ross D, Moody CJ.

Chembiochem. 2011 May 16;12(8):1203-8. doi: 10.1002/cbic.201100085. Epub 2011 Apr 19.

PMID:
21506232
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.

Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR.

Chem Res Toxicol. 2011 May 16;24(5):651-62. doi: 10.1021/tx100355a. Epub 2011 Apr 14.

PMID:
21449565
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

Shearn CT, Fritz KS, Reigan P, Petersen DR.

Biochemistry. 2011 May 17;50(19):3984-96. doi: 10.1021/bi200029w. Epub 2011 Apr 20.

PMID:
21438592
[PubMed - indexed for MEDLINE]

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