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Results: 1 to 20 of 32

1.

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective In Vitro Probes.

Knapinska AM, Dreymuller D, Ludwig A, Smith L, Golubkov V, Sohail A, Fridman R, Giulianotti M, LaVoi T, Houghten RA, Field G, Minond D.

J Med Chem. 2015 Jul 20. [Epub ahead of print]

PMID:
26192023
2.

Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.

Rodriguez MC, Yegorova S, Pitteloud JP, Chavaroche AE, André S, Ardá A, Minond D, Jiménez-Barbero J, Gabius HJ, Cudic M.

Biochemistry. 2015 Jul 28;54(29):4462-74. doi: 10.1021/acs.biochem.5b00555. Epub 2015 Jul 20.

PMID:
26129647
3.

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D.

J Med Chem. 2014 Nov 26;57(22):9598-611. doi: 10.1021/jm501284e. Epub 2014 Nov 11.

PMID:
25330343
4.

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.

Madoux F, Tredup C, Spicer TP, Scampavia L, Chase PS, Hodder PS, Fields GB, Becker-Pauly C, Minond D.

Biopolymers. 2014 Sep;102(5):396-406. doi: 10.1002/bip.22527.

5.

AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α.

Wang H, Nefzi A, Fields GB, Lakshmana MK, Minond D.

Anal Biochem. 2014 Aug 15;459:24-30. doi: 10.1016/j.ab.2014.05.007. Epub 2014 May 20.

PMID:
24857774
6.

Production of soluble Neprilysin by endothelial cells.

Kuruppu S, Rajapakse NW, Minond D, Smith AI.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):423-7. doi: 10.1016/j.bbrc.2014.01.158. Epub 2014 Feb 2.

PMID:
24495806
7.

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis.

Onwuha-Ekpete L, Tack L, Knapinska A, Smith L, Kaushik G, Lavoi T, Giulianotti M, Houghten RA, Fields GB, Minond D.

J Med Chem. 2014 Feb 27;57(4):1599-608. doi: 10.1021/jm4019542. Epub 2014 Feb 5.

8.

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.

Chavaroche A, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D.

Anal Biochem. 2014 Mar 15;449:68-75. doi: 10.1016/j.ab.2013.12.018. Epub 2013 Dec 19.

9.

RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain.

Palavicini JP, Wang H, Minond D, Bianchi E, Xu S, Lakshmana MK.

J Alzheimers Dis. 2014;39(4):727-40. doi: 10.3233/JAD-131550.

PMID:
24254706
10.

Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.

Richard DJ, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH.

Bioorg Med Chem. 2013 Nov 1;21(21):6642-9. doi: 10.1016/j.bmc.2013.08.017. Epub 2013 Aug 15.

11.

COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

Wang H, Dey D, Carrera I, Minond D, Bianchi E, Xu S, Lakshmana MK.

J Biol Chem. 2013 Sep 13;288(37):26668-77. doi: 10.1074/jbc.M113.476689. Epub 2013 Aug 7.

12.

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.

Stawikowska R, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D.

J Biol Chem. 2013 Aug 2;288(31):22871-9. doi: 10.1074/jbc.M113.462267. Epub 2013 Jun 18.

13.

ML302, a Novel Beta-lactamase (BLA) Inhibitor.

Spicer T, Minond D, Enogieru I, Saldanha SA, Allais C, Liu Q, Mercer BA, Roush WR, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2014 May 13].

14.

ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis.

Bannister T, Koenig M, He Y, Mishra J, Spicer T, Minond D, Saldanha A, Mercer BA, Cameron M, Lena R, Carlson N, Richard D, Cardone M, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2013 Mar 14].

15.

Development of an AlphaScreen assay for discovery of inhibitors of low-affinity glycan-lectin interactions.

Yegorova S, Chavaroche AE, Rodriguez MC, Minond D, Cudic M.

Anal Biochem. 2013 Aug 15;439(2):123-31. doi: 10.1016/j.ab.2013.04.028. Epub 2013 May 16.

PMID:
23685052
16.

Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine.

Hayes CD, Dey D, Palavicini JP, Wang H, Patkar KA, Minond D, Nefzi A, Lakshmana MK.

BMC Med. 2013 Mar 26;11:81. doi: 10.1186/1741-7015-11-81.

17.

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

Minond D, Cudic M, Bionda N, Giulianotti M, Maida L, Houghten RA, Fields GB.

J Biol Chem. 2012 Oct 19;287(43):36473-87. doi: 10.1074/jbc.M112.389114. Epub 2012 Aug 27.

18.

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7180-4. doi: 10.1016/j.bmcl.2011.09.077. Epub 2011 Sep 22.

19.

HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors.

Minond D, Saldanha SA, Spicer T, Qin L, Mercer BA, Roush WR, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Nov 13 [updated 2011 May 5].

20.

Probe Report for P97/cdc48 Inhibitors.

Brown SJ, Chou TF, Deshaies R, Roberts E, Guerrero M, Minond D, Mercer BA, Hodder P, Rosen HR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Mar 6 [updated 2010 Aug 6].

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