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Results: 18


Host attachment and fluid shear are integrated into a mechanical signal regulating virulence in Escherichia coli O157:H7.

Alsharif G, Ahmad S, Islam MS, Shah R, Busby SJ, Krachler AM.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5503-8. doi: 10.1073/pnas.1422986112. Epub 2015 Apr 13.


Bacterial fitness shapes the population dynamics of antibiotic-resistant and -susceptible bacteria in a model of combined antibiotic and anti-virulence treatment.

Ternent L, Dyson RJ, Krachler AM, Jabbari S.

J Theor Biol. 2015 May 7;372:1-11. doi: 10.1016/j.jtbi.2015.02.011. Epub 2015 Feb 18.


Fatal attraction: how bacterial adhesins affect host signaling and what we can learn from them.

Stones DH, Krachler AM.

Int J Mol Sci. 2015 Jan 23;16(2):2626-40. doi: 10.3390/ijms16022626.


Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence.

Calder T, de Souza Santos M, Attah V, Klimko J, Fernandez J, Salomon D, Krachler AM, Orth K.

FEMS Microbiol Lett. 2014 Dec;361(2):107-14. doi: 10.1111/1574-6968.12619. Epub 2014 Oct 31.


Multivalent adhesion molecule 7 clusters act as signaling platform for host cellular GTPase activation and facilitate epithelial barrier dysfunction.

Lim J, Stones DH, Hawley CA, Watson CA, Krachler AM.

PLoS Pathog. 2014 Sep 25;10(9):e1004421. doi: 10.1371/journal.ppat.1004421. eCollection 2014 Sep.


A MAM7 peptide-based inhibitor of Staphylococcus aureus adhesion does not interfere with in vitro host cell function.

Hawley CA, Watson CA, Orth K, Krachler AM.

PLoS One. 2013 Nov 12;8(11):e81216. doi: 10.1371/journal.pone.0081216. eCollection 2013.


The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells.

Altura MA, Heath-Heckman EA, Gillette A, Kremer N, Krachler AM, Brennan C, Ruby EG, Orth K, McFall-Ngai MJ.

Environ Microbiol. 2013 Jun 11. doi: 10.1111/1462-2920.12179. [Epub ahead of print]


Targeting the bacteria-host interface: strategies in anti-adhesion therapy.

Krachler AM, Orth K.

Virulence. 2013 May 15;4(4):284-94. doi: 10.4161/viru.24606. Review.


Type III effector VopC mediates invasion for Vibrio species.

Zhang L, Krachler AM, Broberg CA, Li Y, Mirzaei H, Gilpin CJ, Orth K.

Cell Rep. 2012 May 31;1(5):453-60. doi: 10.1016/j.celrep.2012.04.004. Epub 2012 May 3.


In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel.

Krachler AM, Mende K, Murray C, Orth K.

Virulence. 2012 Jul 1;3(4):389-99. doi: 10.4161/viru.20816. Epub 2012 Jun 22.


Manipulation of kinase signaling by bacterial pathogens.

Krachler AM, Woolery AR, Orth K.

J Cell Biol. 2011 Dec 26;195(7):1083-92. doi: 10.1083/jcb.201107132. Epub 2011 Nov 28. Review.


Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent.

Krachler AM, Ham H, Orth K.

Virulence. 2012 Jan-Feb;3(1):68-71. doi: 10.4161/viru.3.1.18172. Epub 2012 Jan 1.


Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands.

Krachler AM, Orth K.

J Biol Chem. 2011 Nov 11;286(45):38939-47. doi: 10.1074/jbc.M111.291377. Epub 2011 Sep 20.


Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by gram-negative pathogens.

Krachler AM, Ham H, Orth K.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11614-9. doi: 10.1073/pnas.1102360108. Epub 2011 Jun 27.


TolA modulates the oligomeric status of YbgF in the bacterial periplasm.

Krachler AM, Sharma A, Cauldwell A, Papadakos G, Kleanthous C.

J Mol Biol. 2010 Oct 22;403(2):270-85. doi: 10.1016/j.jmb.2010.08.050. Epub 2010 Sep 15.


Self-association of TPR domains: Lessons learned from a designed, consensus-based TPR oligomer.

Krachler AM, Sharma A, Kleanthous C.

Proteins. 2010 Jul;78(9):2131-43. doi: 10.1002/prot.22726.


Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.

Bonsor DA, Hecht O, Vankemmelbeke M, Sharma A, Krachler AM, Housden NG, Lilly KJ, James R, Moore GR, Kleanthous C.

EMBO J. 2009 Sep 16;28(18):2846-57. doi: 10.1038/emboj.2009.224. Epub 2009 Aug 20. Erratum in: EMBO J. 2009 Sep 16;28(18):2858.


Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents.

Vargha R, Endemann M, Kratochwill K, Riesenhuber A, Wick N, Krachler AM, Malaga-Dieguez L, Aufricht C.

Nephrol Dial Transplant. 2006 Oct;21(10):2943-7. Epub 2006 Jul 22.

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