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Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.
Bjornsdottir G, Stefansdottir L, Thorleifsson G, Sulem P, Norland K, Ferkingstad E, Oddsson A, Zink F, Lund SH, Nawaz MS, Bragi Walters G, Skuladottir AT, Gudjonsson SA, Einarsson G, Halldorsson GH, Bjarnadottir V, Sveinbjornsson G, Helgadottir A, Styrkarsdottir U, Gudmundsson LJ, Pedersen OB, Hansen TF, Werge T, Banasik K, Troelsen A, Skou ST, Thørner LW, Erikstrup C, Nielsen KR, Mikkelsen S; DBDS Genetic Consortium; GO Consortium; Jonsdottir I, Bjornsson A, Olafsson IH, Ulfarsson E, Blondal J, Vikingsson A, Brunak S, Ostrowski SR, Ullum H, Thorsteinsdottir U, Stefansson H, Gudbjartsson DF, Thorgeirsson TE, Stefansson K. Bjornsdottir G, et al. Nat Commun. 2022 Feb 2;13(1):634. doi: 10.1038/s41467-022-28167-1. Nat Commun. 2022. PMID: 35110524 Free PMC article.
Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. …
Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 …
Potential causal association between leisure sedentary behaviors, physical activity and musculoskeletal health: A Mendelian randomization study.
Zhao X, Yang Y, Yue R, Su C. Zhao X, et al. PLoS One. 2023 Mar 16;18(3):e0283014. doi: 10.1371/journal.pone.0283014. eCollection 2023. PLoS One. 2023. PMID: 36928028 Free PMC article.
In this study, we aimed to evaluate the causal relationships between LSB/PA and lower back pain (LBP), intervertebral disc disorder (IVDD), rheumatoid arthritis (RA), and bone mineral density (BMD) by using a two-sample Mendelian randomization method. ...
In this study, we aimed to evaluate the causal relationships between LSB/PA and lower back pain (LBP), intervertebral disc …
Author Correction: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.
Bjornsdottir G, Stefansdottir L, Thorleifsson G, Sulem P, Norland K, Ferkingstad E, Oddsson A, Zink F, Lund SH, Nawaz MS, Bragi Walters G, Skuladottir AT, Gudjonsson SA, Einarsson G, Halldorsson GH, Bjarnadottir V, Sveinbjornsson G, Helgadottir A, Styrkarsdottir U, Gudmundsson LJ, Pedersen OB, Hansen TF, Werge T, Banasik K, Troelsen A, Skou ST, Thørner LW, Erikstrup C, Nielsen KR, Mikkelsen S; DBDS Genetic Consortium; GO Consortium; Jonsdottir I, Bjornsson A, Olafsson IH, Ulfarsson E, Blondal J, Vikingsson A, Brunak S, Ostrowski SR, Ullum H, Thorsteinsdottir U, Stefansson H, Gudbjartsson DF, Thorgeirsson TE, Stefansson K. Bjornsdottir G, et al. Nat Commun. 2022 Apr 27;13(1):2419. doi: 10.1038/s41467-022-30129-6. Nat Commun. 2022. PMID: 35477715 Free PMC article. No abstract available.
SLC26A1 is a major determinant of sulfate homeostasis in humans.
Pfau A, López-Cayuqueo KI, Scherer N, Wuttke M, Wernstedt A, González Fassrainer D, Smith DE, van de Kamp JM, Ziegeler K, Eckardt KU, Luft FC, Aronson PS, Köttgen A, Jentsch TJ, Knauf F. Pfau A, et al. J Clin Invest. 2023 Feb 1;133(3):e161849. doi: 10.1172/JCI161849. J Clin Invest. 2023. PMID: 36719378 Free PMC article.
In view of recent evidence linking sulfate homeostasis with back pain and intervertebral disc disorder, our study identifies SLC26A1 as a potential target for modulation of musculoskeletal health....
In view of recent evidence linking sulfate homeostasis with back pain and intervertebral disc disorder, our study ident …
Length of stay and readmission in lumbar intervertebral disc disorder inpatients by hospital characteristics and volumes.
Han KT, Lee HJ, Park EC, Kim W, Jang SI, Kim TH. Han KT, et al. Health Policy. 2016 Sep;120(9):1008-16. doi: 10.1016/j.healthpol.2016.08.004. Epub 2016 Aug 17. Health Policy. 2016. PMID: 27568166
In South Korea, lumbar intervertebral disc disorder (LIDD) patients are increasing in all age groups due to an aging population and changes in lifestyle, like sedentary, and there has been concern about reducing quality of care and increasing healthcare expen …
In South Korea, lumbar intervertebral disc disorder (LIDD) patients are increasing in all age groups due to an aging po …
Multi-Trait Exome-Wide Association Study of Back Pain-Related Phenotypes.
Zorkoltseva IV, Elgaeva EE, Belonogova NM, Kirichenko AV, Svishcheva GR, Freidin MB, Williams FMK, Suri P, Tsepilov YA, Axenovich TI. Zorkoltseva IV, et al. Genes (Basel). 2023 Oct 19;14(10):1962. doi: 10.3390/genes14101962. Genes (Basel). 2023. PMID: 37895311 Free PMC article.
This study utilized exome sequencing data from the UK Biobank to perform a multi-trait gene-based association analysis of three BP-related phenotypes: chronic back pain, dorsalgia, and intervertebral disc disorder. We identified the SLC13A1 gene as a contribu …
This study utilized exome sequencing data from the UK Biobank to perform a multi-trait gene-based association analysis of three BP-related p …
Review of Neurosurgery Medical Professional Liability Claims in the United States.
Elsamadicy AA, Sergesketter AR, Frakes MD, Lad SP. Elsamadicy AA, et al. Neurosurgery. 2018 Nov 1;83(5):997-1006. doi: 10.1093/neuros/nyx565. Neurosurgery. 2018. PMID: 29325137 Review.
Of all the neurosurgery claims, the most prevalent chief medical factor was improper performance (42.1%, $124 943 933), presenting medical condition was intervertebral disc disorder (20.6%, $54 223 206), and operative procedure performed involved the spinal c …
Of all the neurosurgery claims, the most prevalent chief medical factor was improper performance (42.1%, $124 943 933), presenting medical c …
Intervertebral disc modeling using a MRI method: migration of the nucleus zone within scoliotic intervertebral discs.
Périé D, Sales de Gauzy J, Curnier D, Hobatho MC. Périé D, et al. Magn Reson Imaging. 2001 Nov;19(9):1245-8. doi: 10.1016/s0730-725x(01)00452-0. Magn Reson Imaging. 2001. PMID: 11755736
MRI is increasingly being used for etiologic examination of scoliosis and for intervertebral disc disorder analysis, but until now has not been applied to geometric modeling. ...
MRI is increasingly being used for etiologic examination of scoliosis and for intervertebral disc disorder analysis, bu …
Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.
Henkel C, Styrkársdóttir U, Thorleifsson G, Stefánsdóttir L, Björnsdóttir G, Banasik K, Brunak S, Erikstrup C, Dinh KM, Hansen TF, Nielsen KR, Bruun MT, Dowsett J, Brodersen T; DBDS Genomic Consortium; Thorgeirsson TE, Gromov K, Boesen MP, Ullum H, Ostrowski SR, Pedersen OB, Stefánsson K, Troelsen A. Henkel C, et al. Ann Rheum Dis. 2023 Mar;82(3):384-392. doi: 10.1136/ard-2022-223199. Epub 2022 Nov 14. Ann Rheum Dis. 2023. PMID: 36376028
In addition, we tested for genetic correlation between the osteoarthritis groups and the pain phenotypes intervertebral disc disorder, dorsalgia, fibromyalgia, migraine and joint pain. ...
In addition, we tested for genetic correlation between the osteoarthritis groups and the pain phenotypes intervertebral disc …
27 results