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Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.
Jauhiainen S, Häkkinen SK, Toivanen PI, Heinonen SE, Jyrkkänen HK, Kansanen E, Leinonen H, Levonen AL, Ylä-Herttuala S. Jauhiainen S, et al. Among authors: hakkinen sk. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1617-24. doi: 10.1161/ATVBAHA.111.225961. Epub 2011 Apr 7. Arterioscler Thromb Vasc Biol. 2011. PMID: 21474827
Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster.
Aavik E, Lumivuori H, Leppänen O, Wirth T, Häkkinen SK, Bräsen JH, Beschorner U, Zeller T, Braspenning M, van Criekinge W, Mäkinen K, Ylä-Herttuala S. Aavik E, et al. Among authors: hakkinen sk. Eur Heart J. 2015 Apr 21;36(16):993-1000. doi: 10.1093/eurheartj/ehu437. Epub 2014 Nov 16. Eur Heart J. 2015. PMID: 25411193
Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.
Kansanen E, Jyrkkänen HK, Volger OL, Leinonen H, Kivelä AM, Häkkinen SK, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen AL. Kansanen E, et al. Among authors: hakkinen sk. J Biol Chem. 2009 Nov 27;284(48):33233-41. doi: 10.1074/jbc.M109.064873. Epub 2009 Oct 5. J Biol Chem. 2009. PMID: 19808663 Free PMC article.
Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors.
Kurki MI, Häkkinen SK, Frösen J, Tulamo R, von und zu Fraunberg M, Wong G, Tromp G, Niemelä M, Hernesniemi J, Jääskeläinen JE, Ylä-Herttuala S. Kurki MI, et al. Among authors: hakkinen sk. Neurosurgery. 2011 Jun;68(6):1667-75; discussion 1675-6. doi: 10.1227/NEU.0b013e318210f001. Neurosurgery. 2011. PMID: 21336216