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A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis.

Henkels KM, Miller TE, Ganesan R, Wilkins BA, Fite K, Gomez-Cambronero J.

Oncotarget. 2016 May 31. doi: 10.18632/oncotarget.9685. [Epub ahead of print]


A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells.

Fite K, Elkhadragy L, Gomez-Cambronero J.

Mol Cell Biol. 2016 Jan 19;36(7):1078-89. doi: 10.1128/MCB.00711-15.


The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion.

Ganesan R, Mallets E, Gomez-Cambronero J.

Mol Oncol. 2016 May;10(5):663-76. doi: 10.1016/j.molonc.2015.12.006. Epub 2015 Dec 19.


Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.

Fite K, Gomez-Cambronero J.

J Biol Chem. 2016 Jan 8;291(2):719-30. doi: 10.1074/jbc.M115.686006. Epub 2015 Nov 15.


Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells.

Mahankali M, Farkaly T, Bedi S, Hostetler HA, Gomez-Cambronero J.

Sci Rep. 2015 Oct 23;5:15379. doi: 10.1038/srep15379.


Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor.

Hatton N, Lintz E, Mahankali M, Henkels KM, Gomez-Cambronero J.

Mol Cell Biol. 2015 Sep;35(18):3131-44. doi: 10.1128/MCB.00286-15. Epub 2015 Jun 29.


Adenovirus entry from the apical surface of polarized epithelia is facilitated by the host innate immune response.

Kotha PL, Sharma P, Kolawole AO, Yan R, Alghamri MS, Brockman TL, Gomez-Cambronero J, Excoffon KJ.

PLoS Pathog. 2015 Mar 13;11(3):e1004696. doi: 10.1371/journal.ppat.1004696. eCollection 2015 Mar.


FASEB Science Research Conference on phospholipid cell signaling and metabolism in inflammation and cancer.

Gomez-Cambronero J.

FASEB J. 2015 Jan;29(1):5-10. doi: 10.1096/fj.15-0102ufm. No abstract available.


Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket.

Ganesan R, Mahankali M, Alter G, Gomez-Cambronero J.

Biochim Biophys Acta. 2015 Mar;1851(3):261-72. doi: 10.1016/j.bbalip.2014.12.007. Epub 2014 Dec 20.


S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding.

Henkels KM, Mallets ER, Dennis PB, Gomez-Cambronero J.

FASEB J. 2015 Apr;29(4):1299-313. doi: 10.1096/fj.14-260992. Epub 2014 Dec 15.


A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src.

Mahankali M, Henkels KM, Speranza F, Gomez-Cambronero J.

J Cell Sci. 2015 Feb 1;128(3):516-26.


Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model.

Mahankali M, Alter G, Gomez-Cambronero J.

Cell Signal. 2015 Jan;27(1):69-81. doi: 10.1016/j.cellsig.2014.09.008. Epub 2014 Oct 12.


The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.

Speranza F, Mahankali M, Henkels KM, Gomez-Cambronero J.

J Biol Chem. 2014 Oct 17;289(42):28885-97. doi: 10.1074/jbc.M114.597146. Epub 2014 Sep 2.


A river runs through it: how autophagy, senescence, and phagocytosis could be linked to phospholipase D by Wnt signaling.

Gomez-Cambronero J, Kantonen S.

J Leukoc Biol. 2014 Nov;96(5):779-84. doi: 10.1189/jlb.2VMR0214-120RR. Epub 2014 Jul 31. Review.


Thematic minireview series on phospholipase D and cancer.

Gomez-Cambronero J, Carman GM.

J Biol Chem. 2014 Aug 15;289(33):22554-6. doi: 10.1074/jbc.R114.593137. Epub 2014 Jul 2.


Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.

Gomez-Cambronero J.

J Biol Chem. 2014 Aug 15;289(33):22557-66. doi: 10.1074/jbc.R114.574152. Epub 2014 Jul 2. Review.


Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.

Usatyuk PV, Fu P, Mohan V, Epshtein Y, Jacobson JR, Gomez-Cambronero J, Wary KK, Bindokas V, Dudek SM, Salgia R, Garcia JG, Natarajan V.

J Biol Chem. 2014 May 9;289(19):13476-91. doi: 10.1074/jbc.M113.527556. Epub 2014 Mar 14.


Phosphatidic acid, phospholipase D and tumorigenesis.

Gomez-Cambronero J.

Adv Biol Regul. 2014 Jan;54:197-206. doi: 10.1016/j.jbior.2013.08.006. Epub 2013 Sep 19.


Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression.

Speranza FJ, Mahankali M, Gomez-Cambronero J.

J Leukoc Biol. 2013 Nov;94(5):953-62. doi: 10.1189/jlb.0313174. Epub 2013 Jul 29.


Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.

Henkels KM, Boivin GP, Dudley ES, Berberich SJ, Gomez-Cambronero J.

Oncogene. 2013 Dec 5;32(49):5551-62. doi: 10.1038/onc.2013.207. Epub 2013 Jun 10.

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