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Results: 1 to 20 of 251

1.

Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats.

Nistri S, Di Cesare Mannelli L, Ghelardini C, Zanardelli M, Bani D, Failli P.

Molecules. 2015 May 26;20(6):9524-35. doi: 10.3390/molecules20069524.

2.

6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells.

Grandane A, Tanc M, Di Cesare Mannelli L, Carta F, Ghelardini C, Žalubovskis R, Supuran CT.

J Med Chem. 2015 May 14;58(9):3975-83. doi: 10.1021/acs.jmedchem.5b00523. Epub 2015 Apr 23.

PMID:
25875209
3.

Delay of morphine tolerance by palmitoylethanolamide.

Di Cesare Mannelli L, Corti F, Micheli L, Zanardelli M, Ghelardini C.

Biomed Res Int. 2015;2015:894732. doi: 10.1155/2015/894732. Epub 2015 Mar 22.

4.

Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.

Guandalini L, Martino MV, Di Cesare Mannelli L, Bartolucci G, Melani F, Malik R, Dei S, Floriddia E, Manetti D, Orlandi F, Teodori E, Ghelardini C, Romanelli MN.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1700-4. doi: 10.1016/j.bmcl.2015.03.009. Epub 2015 Mar 12.

PMID:
25813160
5.

Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low dose morphine thermal hyperalgesia.

Sanna MD, Ghelardini C, Galeotti N.

Pain. 2015 Mar 23. [Epub ahead of print]

PMID:
25806604
6.

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.

Carta F, Di Cesare Mannelli L, Pinard M, Ghelardini C, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2015 Apr 15;23(8):1828-40. doi: 10.1016/j.bmc.2015.02.027. Epub 2015 Feb 21.

PMID:
25766630
7.

Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy.

Sanna MD, Peroni D, Quattrone A, Ghelardini C, Galeotti N.

Exp Neurol. 2015 May;267:53-63. doi: 10.1016/j.expneurol.2015.02.036. Epub 2015 Mar 10.

PMID:
25765490
8.

Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells.

Zanardelli M, Micheli L, Nicolai R, Failli P, Ghelardini C, Di Cesare Mannelli L.

Int J Mol Sci. 2015 Mar 9;16(3):5386-99. doi: 10.3390/ijms16035386.

9.

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats.

Micheli L, Di Cesare Mannelli L, Guerrini R, Trapella C, Zanardelli M, Ciccocioppo R, Rizzi A, Ghelardini C, Calò G.

Eur J Pharmacol. 2015 May 5;754:73-81. doi: 10.1016/j.ejphar.2015.02.020. Epub 2015 Feb 19.

PMID:
25704616
10.

Oxidative, Metabolic, and Apoptotic Responses of Schwann Cells to High Glucose Levels.

Cinci L, Corti F, Di Cesare Mannelli L, Micheli L, Zanardelli M, Ghelardini C.

J Biochem Mol Toxicol. 2015 Feb 12. doi: 10.1002/jbt.21695. [Epub ahead of print]

PMID:
25683646
11.

Differential contribution of Gαi/o subunits in the response to food deprivation.

Sanna MD, Ghelardini C, Galeotti N.

Eur J Pharmacol. 2015 Mar 5;750:27-31. doi: 10.1016/j.ejphar.2015.01.012. Epub 2015 Jan 22.

PMID:
25620129
12.

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.

Consalvi S, Alfonso S, Di Capua A, Poce G, Pirolli A, Sabatino M, Ragno R, Anzini M, Sartini S, La Motta C, Di Cesare Mannelli L, Ghelardini C, Biava M.

Bioorg Med Chem. 2015 Feb 15;23(4):810-20. doi: 10.1016/j.bmc.2014.12.041. Epub 2014 Dec 26.

PMID:
25596758
13.

Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain.

Gualdani R, Ceruti S, Magni G, Merli D, Di Cesare Mannelli L, Francesconi O, Richichi B, la Marca G, Ghelardini C, Moncelli MR, Nativi C.

ACS Chem Neurosci. 2015 Mar 18;6(3):380-5. doi: 10.1021/cn500248u. Epub 2015 Jan 6.

PMID:
25546551
14.

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

Giovannoni MP, Ciciani G, Cilibrizzi A, Crocetti L, Daniele S, Di Cesare Mannelli L, Ghelardini C, Giacomelli C, Guerrini G, Martini C, Trincavelli ML, Vergelli C.

Eur J Med Chem. 2015 Jan 7;89:32-41. doi: 10.1016/j.ejmech.2014.10.020. Epub 2014 Oct 12.

PMID:
25462223
15.

Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.

Ghelardini C, Menicacci C, Cerretani D, Bianchi E.

Neuropharmacology. 2014 Nov;86:294-300. doi: 10.1016/j.neuropharm.2014.08.004. Epub 2014 Aug 13.

PMID:
25128849
16.

Oxaliplatin neurotoxicity involves peroxisome alterations. PPARγ agonism as preventive pharmacological approach.

Zanardelli M, Micheli L, Cinci L, Failli P, Ghelardini C, Di Cesare Mannelli L.

PLoS One. 2014 Jul 18;9(7):e102758. doi: 10.1371/journal.pone.0102758. eCollection 2014.

17.

Α-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement.

Di Cesare Mannelli L, Cinci L, Micheli L, Zanardelli M, Pacini A, McIntosh JM, Ghelardini C.

Pain. 2014 Oct;155(10):1986-95. doi: 10.1016/j.pain.2014.06.023. Epub 2014 Jul 5.

PMID:
25008370
18.

BDNF and ARTEMIN are increased in drug-naïve non-depressed GAD patients: preliminary data.

Pallanti S, Tofani T, Zanardelli M, Di Cesare Mannelli L, Ghelardini C.

Int J Psychiatry Clin Pract. 2014 Oct;18(4):255-60. doi: 10.3109/13651501.2014.940051. Epub 2014 Aug 12.

PMID:
24994477
19.

Glial role in oxaliplatin-induced neuropathic pain.

Di Cesare Mannelli L, Pacini A, Micheli L, Tani A, Zanardelli M, Ghelardini C.

Exp Neurol. 2014 Nov;261:22-33. doi: 10.1016/j.expneurol.2014.06.016. Epub 2014 Jun 23.

PMID:
24967684
20.

Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: a step toward improving opioid pain therapy.

Sanna MD, Ghelardini C, Galeotti N.

Neuropharmacology. 2014 Nov;86:67-77. doi: 10.1016/j.neuropharm.2014.06.007. Epub 2014 Jun 17.

PMID:
24950452
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