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Excess body weight increases the burden of age-associated chronic diseases and their associated health care expenditures.

Atella V, Kopinska J, Medea G, Belotti F, Tosti V, Mortari AP, Cricelli C, Fontana L.

Aging (Albany NY). 2015 Oct;7(10):882-92.


A zebrafish model of Poikiloderma with Neutropenia recapitulates the human syndrome hallmarks and traces back neutropenia to the myeloid progenitor.

Colombo EA, Carra S, Fontana L, Bresciani E, Cotelli F, Larizza L.

Sci Rep. 2015 Nov 2;5:15814. doi: 10.1038/srep15814.


A case of unilateral hemolacria.

Iovieno A, Coassin M, Piana S, De Luca M, Giunta P, Fontana L.

Int Ophthalmol. 2015 Oct 27. [Epub ahead of print] No abstract available.


Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial.

Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO; CALERIE Study Group.

Aging Cell. 2015 Oct 6. doi: 10.1111/acel.12400. [Epub ahead of print]


Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society.

Nikolich-Žugich J, Goldman DP, Cohen PR, Cortese D, Fontana L, Kennedy BK, Mohler MJ, Olshansky SJ, Perls T, Perry D, Richardson A, Ritchie C, Wertheimer AM, Faragher RG, Fain MJ.

J Gerontol A Biol Sci Med Sci. 2015 Sep 29. pii: glv164. [Epub ahead of print]


Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel.

Dey N, Wagner VE, Blanton LV, Cheng J, Fontana L, Haque R, Ahmed T, Gordon JI.

Cell. 2015 Sep 24;163(1):95-107. doi: 10.1016/j.cell.2015.08.059.


Expansion size and presence of CCG/CTC/CGG sequence interruptions in the expanded CTG array are independently associated to hypermethylation at the DMPK locus in myotonic dystrophy type 1 (DM1).

Santoro M, Fontana L, Masciullo M, Bianchi ML, Rossi S, Leoncini E, Novelli G, Botta A, Silvestri G.

Biochim Biophys Acta. 2015 Dec;1852(12):2645-52. doi: 10.1016/j.bbadis.2015.09.007. Epub 2015 Sep 21. No abstract available.


Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model.

Lamming DW, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana L.

Oncotarget. 2015 Oct 13;6(31):31233-40. doi: 10.18632/oncotarget.5180.


Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-obese Younger Adults: a Randomized Clinical Trial.

Villareal DT, Fontana L, Das SK, Redman L, Smith SR, Saltzman E, Bales C, Rochon J, Pieper C, Huang M, Lewis M, Schwartz AV; CALERIE Study Group.

J Bone Miner Res. 2015 Aug 31. doi: 10.1002/jbmr.2701. [Epub ahead of print]


Expanding the role of the splicing USB1 gene from Poikiloderma with Neutropenia to acquired myeloid neoplasms.

Negri G, Crescenzi B, Colombo EA, Fontana L, Barba G, Arcioni F, Gervasini C, Mecucci C, Larizza L.

Br J Haematol. 2015 Nov;171(4):557-65. doi: 10.1111/bjh.13651. Epub 2015 Aug 25.


Evaluation of Left Ventricle Function by Regional Fractional Area Change (RFAC) in a Mouse Model of Myocardial Infarction Secondary to Valsartan Treatment.

Castiglioni L, Colazzo F, Fontana L, Colombo GI, Piacentini L, Bono E, Milano G, Paleari S, Palermo A, Guerrini U, Tremoli E, Sironi L.

PLoS One. 2015 Aug 20;10(8):e0135778. doi: 10.1371/journal.pone.0135778. eCollection 2015.


Bioconjugation of gold-polymer core-shell nanoparticles with bovine serum amine oxidase for biomedical applications.

Venditti I, Hassanein TF, Fratoddi I, Fontana L, Battocchio C, Rinaldi F, Carafa M, Marianecci C, Diociaiuti M, Agostinelli E, Cametti C, Russo MV.

Colloids Surf B Biointerfaces. 2015 Oct 1;134:314-21. doi: 10.1016/j.colsurfb.2015.06.052. Epub 2015 Jul 2.


A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.

Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB; CALERIE Study Group.

J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1097-104. doi: 10.1093/gerona/glv057. Epub 2015 Jul 17.


Beckwith-Wiedemann syndrome prenatal diagnosis by methylation analysis in chorionic villi.

Paganini L, Carlessi N, Fontana L, Silipigni R, Motta S, Fiori S, Guerneri S, Lalatta F, Cereda A, Sirchia S, Miozzo M, Tabano S.

Epigenetics. 2015;10(7):643-9. doi: 10.1080/15592294.2015.1057383.


Pyrosequencing analysis reveals changes in intestinal microbiota of healthy adults who received a daily dose of immunomodulatory probiotic strains.

Plaza-Díaz J, Fernández-Caballero JÁ, Chueca N, García F, Gómez-Llorente C, Sáez-Lara MJ, Fontana L, Gil Á.

Nutrients. 2015 May 26;7(6):3999-4015. doi: 10.3390/nu7063999.


Candida rugosa lipase immobilization on hydrophilic charged gold nanoparticles as promising biocatalysts: Activity and stability investigations.

Venditti I, Palocci C, Chronopoulou L, Fratoddi I, Fontana L, Diociaiuti M, Russo MV.

Colloids Surf B Biointerfaces. 2015 Jul 1;131:93-101. doi: 10.1016/j.colsurfb.2015.04.046. Epub 2015 Apr 27.


Murine left atrium and left atrial appendage structure and function: echocardiographic and morphologic evaluation.

Colazzo F, Castiglioni L, Sironi L, Fontana L, Nobili E, Franzosi M, Guerrini U.

PLoS One. 2015 Apr 30;10(4):e0125541. doi: 10.1371/journal.pone.0125541. eCollection 2015.


Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22.


Gut microbiota and Ma-Pi 2 macrobiotic diet in the treatment of type 2 diabetes.

Fallucca F, Fontana L, Fallucca S, Pianesi M.

World J Diabetes. 2015 Apr 15;6(3):403-11. doi: 10.4239/wjd.v6.i3.403. Review.


Risk factors for work-related stress and subjective hardship in health-care staff in nursing homes for the elderly: A cross-sectional study.

Pélissier C, Vohito M, Fort E, Sellier B, Agard JP, Fontana L, Charbotel B.

J Occup Health. 2015;57(3):285-96. doi: 10.1539/joh.14-0090-OA. Epub 2015 Apr 10.

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