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Results: 1 to 20 of 150


Therapeutic targeting of replicative immortality.

Yaswen P, MacKenzie KL, Keith WN, Hentosh P, Rodier F, Zhu J, Firestone GL, Matheu A, Carnero A, Bilsland A, Sundin T, Honoki K, Fujii H, Georgakilas AG, Amedei A, Amin A, Helferich B, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Niccolai E, Aquilano K, Ashraf SS, Nowsheen S, Yang X.

Semin Cancer Biol. 2015 Apr 10. pii: S1044-579X(15)00022-X. doi: 10.1016/j.semcancer.2015.03.007. [Epub ahead of print] Review.


Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells.

Hargraves KG, He L, Firestone GL.

Mol Carcinog. 2015 Mar 19. doi: 10.1002/mc.22296. [Epub ahead of print]


Minireview: Steroid/nuclear receptor-regulated dynamics of occluding and anchoring junctions.

Firestone GL, Kapadia BJ.

Mol Endocrinol. 2014 Nov;28(11):1769-84. doi: 10.1210/me.2014-1037. Epub 2014 Sep 9.


The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.

Aronchik I, Kundu A, Quirit JG, Firestone GL.

Mol Cancer Res. 2014 Nov;12(11):1621-34. doi: 10.1158/1541-7786.MCR-14-0018. Epub 2014 Jul 9.


3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells.

Nicastro HL, Firestone GL, Bjeldanes LF.

J Nutr Biochem. 2013 Nov;24(11):1882-8. doi: 10.1016/j.jnutbio.2013.05.004. Epub 2013 Aug 19.


Minireview: regulation of gap junction dynamics by nuclear hormone receptors and their ligands.

Firestone GL, Kapadia BJ.

Mol Endocrinol. 2012 Nov;26(11):1798-807. doi: 10.1210/me.2012-1065. Epub 2012 Aug 30. Review.


Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

Marconett CN, Singhal AK, Sundar SN, Firestone GL.

Mol Cell Endocrinol. 2012 Nov 5;363(1-2):74-84. doi: 10.1016/j.mce.2012.07.008. Epub 2012 Jul 24.


Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes.

Tin AS, Sundar SN, Tran KQ, Park AH, Poindexter KM, Firestone GL.

Anticancer Drugs. 2012 Apr;23(4):370-9. doi: 10.1097/CAD.0b013e32834f6ea8.


Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.

Aronchik I, Chen T, Durkin KA, Horwitz MS, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Mol Carcinog. 2012 Nov;51(11):881-94. doi: 10.1002/mc.20857. Epub 2011 Oct 19.


Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.

Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL.

Carcinogenesis. 2011 Sep;32(9):1315-23. doi: 10.1093/carcin/bgr116. Epub 2011 Jun 21.


Unraveling the intricacies of receptor activated cell signaling and transcriptional cascades enhance opportunities to develop new therapeutic targets for endocrine and metabolic diseases.

Firestone GL.

Curr Opin Pharmacol. 2010 Dec;10(6):607-12. doi: 10.1016/j.coph.2010.10.001. Epub 2010 Oct 28. No abstract available.


BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype.

Marconett CN, Morgenstern TJ, San Roman AK, Sundar SN, Singhal AK, Firestone GL.

Cancer Biol Ther. 2010 Aug 15;10(4):397-405. Epub 2010 Aug 20.


1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.

Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, Kung J, Staub RE, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Chem Biol Interact. 2010 Aug 5;186(3):255-66. doi: 10.1016/j.cbi.2010.05.015. Epub 2010 Jun 2.


Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.

Aronchik I, Bjeldanes LF, Firestone GL.

Cancer Res. 2010 Jun 15;70(12):4961-71. doi: 10.1158/0008-5472.CAN-09-3349. Epub 2010 Jun 8.


Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane.

Vivar OI, Saunier EF, Leitman DC, Firestone GL, Bjeldanes LF.

Endocrinology. 2010 Apr;151(4):1662-7. doi: 10.1210/en.2009-1028. Epub 2010 Feb 16.


Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.

Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF, Firestone GL.

Mol Biol Cell. 2010 Apr 1;21(7):1166-77. doi: 10.1091/mbc.E09-08-0689. Epub 2010 Feb 3.

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