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Results: 1 to 20 of 174

1.

Mitochondrial NLRP3 Induces Reactive Oxygen Species to Promote Smad Signalling and Fibrosis Independent from the Inflammasome.

Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.

J Biol Chem. 2014 May 19. pii: jbc.M114.550624. [Epub ahead of print]

PMID:
24841199
[PubMed - as supplied by publisher]
Free Article
2.

Rehabilitating drug-induced long-QT promoters: in-silico design of hERG-neutral cisapride analogues with retained pharmacological activity.

Durdagi S, Randall T, Duff HJ, Chamberlin A, Noskov SY.

BMC Pharmacol Toxicol. 2014 Mar 8;15(1):14. doi: 10.1186/2050-6511-15-14.

PMID:
24606761
[PubMed - in process]
Free PMC Article
3.

Beyond doctrine and dogma: one gene--multisystem effects.

Duff HJ.

Circ Cardiovasc Genet. 2014 Feb;7(1):4. doi: 10.1161/CIRCGENETICS.114.000508. No abstract available.

PMID:
24550429
[PubMed - in process]
4.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR.

Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.

PMID:
24441828
[PubMed - indexed for MEDLINE]
5.

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ.

Circ Cardiovasc Genet. 2013 Aug;6(4):327-36. doi: 10.1161/CIRCGENETICS.113.000097. Epub 2013 Jul 17.

PMID:
23863954
[PubMed - indexed for MEDLINE]
6.

Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.

Circ Res. 2013 Aug 16;113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.

PMID:
23856523
[PubMed - indexed for MEDLINE]
7.

Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium.

Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, Muruve DA.

J Immunol. 2013 Feb 1;190(3):1239-49. doi: 10.4049/jimmunol.1201959. Epub 2012 Dec 21.

PMID:
23264657
[PubMed - indexed for MEDLINE]
Free Article
8.

Auto-entrainment risk assessment in heart failure.

Roach DE, Morck ML, Sheldon RS, Duff HJ.

Circ Arrhythm Electrophysiol. 2013 Feb;6(1):129-36. doi: 10.1161/CIRCEP.112.971986. Epub 2012 Dec 22.

PMID:
23264372
[PubMed - indexed for MEDLINE]
Free Article
9.

Modeling of open, closed, and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.

Durdagi S, Deshpande S, Duff HJ, Noskov SY.

J Chem Inf Model. 2012 Oct 22;52(10):2760-74. doi: 10.1021/ci300353u. Epub 2012 Oct 2.

PMID:
22989185
[PubMed - indexed for MEDLINE]
10.

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.

Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.

PMID:
22848083
[PubMed - indexed for MEDLINE]
Free Article
11.

Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.

Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ.

J Pharmacol Exp Ther. 2012 Aug;342(2):441-52. doi: 10.1124/jpet.111.189159. Epub 2012 May 9.

PMID:
22573844
[PubMed - indexed for MEDLINE]
Free Article
12.

Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism.

Fedak PW, Bai L, Turnbull J, Ngu J, Narine K, Duff HJ.

Circ Heart Fail. 2012 May 1;5(3):349-56. doi: 10.1161/CIRCHEARTFAILURE.111.965889. Epub 2012 Apr 16.

PMID:
22508775
[PubMed - indexed for MEDLINE]
Free Article
13.

Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes.

Shafa M, Krawetz R, Zhang Y, Rattner JB, Godollei A, Duff HJ, Rancourt DE.

BMC Cell Biol. 2011 Dec 14;12:53. doi: 10.1186/1471-2121-12-53.

PMID:
22168552
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.

Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR.

Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.

PMID:
21743453
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Combined receptor and ligand-based approach to the universal pharmacophore model development for studies of drug blockade to the hERG1 pore domain.

Durdagi S, Duff HJ, Noskov SY.

J Chem Inf Model. 2011 Feb 28;51(2):463-74. doi: 10.1021/ci100409y. Epub 2011 Jan 11.

PMID:
21241063
[PubMed - indexed for MEDLINE]
16.

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY.

Proteins. 2010 Nov 1;78(14):2922-34. doi: 10.1002/prot.22815.

PMID:
20740484
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Insights into the molecular mechanism of hERG1 channel activation and blockade by drugs.

Durdagi S, Subbotina J, Lees-Miller J, Guo J, Duff HJ, Noskov SY.

Curr Med Chem. 2010;17(30):3514-32. Review.

PMID:
20738248
[PubMed - indexed for MEDLINE]
18.

Impact of atrial antitachycardia pacing and atrial pace prevention therapies on atrial fibrillation burden over long-term follow-up.

Gillis AM, Morck M, Exner DV, Sheldon RS, Duff HJ, Mitchell BL, Wyse GD.

Europace. 2009 Aug;11(8):1041-7. doi: 10.1093/europace/eup115. Epub 2009 May 21.

PMID:
19460849
[PubMed - indexed for MEDLINE]
Free Article
19.

Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function.

Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ.

Biophys J. 2009 May 6;96(9):3600-10. doi: 10.1016/j.bpj.2009.01.028.

PMID:
19413965
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.

Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC.

Nat Med. 2009 Apr;15(4):380-3. doi: 10.1038/nm.1942. Epub 2009 Mar 29.

PMID:
19330009
[PubMed - indexed for MEDLINE]
Free PMC Article

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