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High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention.

Marchant I, Boissel JP, Nony P, Gueyffier F.

PLoS One. 2015 Nov 3;10(11):e0140793. doi: 10.1371/journal.pone.0140793. eCollection 2015.


Comparative transcriptomic analysis between an artificially induced SIRS in healthy individuals and spontaneous sepsis.

Monteiro Sousa C, Boissel JP, Gueyffier F, Olivera-Botello G.

C R Biol. 2015 Oct;338(10):635-42. doi: 10.1016/j.crvi.2015.05.001. Epub 2015 Aug 11.


Bridging Systems Medicine and Patient Needs.

Boissel JP, Auffray C, Noble D, Hood L, Boissel FH.

CPT Pharmacometrics Syst Pharmacol. 2015 Mar;4(3):e00026. doi: 10.1002/psp4.26. Epub 2015 Mar 27. Review.


Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders.

Nava C, Rupp J, Boissel JP, Mignot C, Rastetter A, Amiet C, Jacquette A, Dupuits C, Bouteiller D, Keren B, Ruberg M, Faudet A, Doummar D, Philippe A, Périsse D, Laurent C, Lebrun N, Guillemot V, Chelly J, Cohen D, Héron D, Brice A, Closs EI, Depienne C.

Amino Acids. 2015 Dec;47(12):2647-58. doi: 10.1007/s00726-015-2057-3. Epub 2015 Jul 28.


An in silico target identification using Boolean network attractors: Avoiding pathological phenotypes.

Poret A, Boissel JP.

C R Biol. 2014 Dec;337(12):661-78. doi: 10.1016/j.crvi.2014.10.002. Epub 2014 Nov 11.


System L amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-L-tyrosine (FET).

Habermeier A, Graf J, Sandhöfer BF, Boissel JP, Roesch F, Closs EI.

Amino Acids. 2015 Feb;47(2):335-44. doi: 10.1007/s00726-014-1863-3. Epub 2014 Nov 11.


Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population.

Kahoul R, Gueyffier F, Amsallem E, Haugh M, Marchant I, Boissel FH, Boissel JP.

J R Soc Interface. 2014 Nov 6;11(100):20140867. doi: 10.1098/rsif.2014.0867.


Better defining target populations for drugs with a view to reimbursement.

Massol J, Boissel JP.

Therapie. 2014 May-Jun;69(3):235-7. doi: 10.2515/therapie/2014027. Epub 2014 Jun 16.


Prediction of chronic lung allograft dysfunction: a systems medicine challenge.

Pison C, Magnan A, Botturi K, Sève M, Brouard S, Marsland BJ, Ernst F, Paprotka T, Deplanche K, Fritz A, Siroux V, Boissel JP, Corris PA, Auffray C, Nicod LP; SysCLAD consortium.

Eur Respir J. 2014 Mar;43(3):689-93. doi: 10.1183/09031936.00161313. No abstract available.


Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.

Beyer SR, Mallmann RT, Jaenecke I, Habermeier A, Boissel JP, Closs EI.

J Biol Chem. 2013 Oct 18;288(42):30411-9. doi: 10.1074/jbc.M113.490698. Epub 2013 Sep 9.


Effect model law: an approach for the implementation of personalized medicine.

Boissel JP, Kahoul R, Marin D, Boissel FH.

J Pers Med. 2013 Aug 15;3(3):177-90. doi: 10.3390/jpm3030177. Review.


A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.

Jaenecke I, Boissel JP, Lemke M, Rupp J, Gasnier B, Closs EI.

J Biol Chem. 2012 Aug 31;287(36):30853-60. doi: 10.1074/jbc.M112.350322. Epub 2012 Jul 11.


Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

Boussageon R, Supper I, Bejan-Angoulvant T, Kellou N, Cucherat M, Boissel JP, Kassai B, Moreau A, Gueyffier F, Cornu C.

PLoS Med. 2012;9(4):e1001204. doi: 10.1371/journal.pmed.1001204. Epub 2012 Apr 10.


The global risk approach should be better applied in French hypertensive patients: a comparison between simulation and observation studies.

Marchant I, Nony P, Cucherat M, Boissel JP, Thomas SR, Bejan-Angoulvant T, Laugerotte A, Kahoul R, Gueyffier F.

PLoS One. 2011 Mar 3;6(3):e17508. doi: 10.1371/journal.pone.0017508.


In silico study of the influence of intensity and duration of blood flow reduction on cell death through necrosis or apoptosis during acute ischemic stroke.

Chapuisat G, Dronne MA, Grenier E, Hommel M, Boissel JP.

Acta Biotheor. 2010 Sep;58(2-3):171-90. doi: 10.1007/s10441-010-9100-2. Epub 2010 Jul 28.


SCORE should be preferred to Framingham to predict cardiovascular death in French population.

Marchant I, Boissel JP, Kassaï B, Bejan T, Massol J, Vidal C, Amsallem E, Naudin F, Galan P, Czernichow S, Nony P, Gueyffier F.

Eur J Cardiovasc Prev Rehabil. 2009 Oct;16(5):609-15. doi: 10.1097/HJR.0b013e32832da006.


Rationale for carbon ion therapy in high-grade glioma based on a review and a meta-analysis of neutron beam trials.

Maucort-Boulch D, Baron MH, Pommier P, Weber DC, Mizoe JE, Rochat J, Boissel JP, Balosso J, Tsujii H, Amsallem E.

Cancer Radiother. 2010 Jan;14(1):34-41. doi: 10.1016/j.canrad.2009.08.141. Epub 2009 Dec 8. Review.


Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells.

Lelekov-Boissard T, Chapuisat G, Boissel JP, Grenier E, Dronne MA.

Philos Trans A Math Phys Eng Sci. 2009 Dec 13;367(1908):4699-716. doi: 10.1098/rsta.2009.0184.


A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy.

Billy F, Ribba B, Saut O, Morre-Trouilhet H, Colin T, Bresch D, Boissel JP, Grenier E, Flandrois JP.

J Theor Biol. 2009 Oct 21;260(4):545-62. doi: 10.1016/j.jtbi.2009.06.026. Epub 2009 Jul 15.


Revisiting the level of evidence in randomized controlled clinical trials: A simulation approach.

Bajard A, Chabaud S, Pérol D, Boissel JP, Nony P.

Contemp Clin Trials. 2009 Sep;30(5):400-10. doi: 10.1016/j.cct.2009.06.005. Epub 2009 Jul 1.

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