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Results: 1 to 20 of 23

1.
2.

HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma.

Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S.

Oncotarget. 2015 Mar 10;6(7):4863-87.

3.

Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.

Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN.

Oncotarget. 2014 Jul 30;5(14):5637-50.

4.

Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression.

Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB.

Epigenetics Chromatin. 2013 Aug 15;6(1):27. doi: 10.1186/1756-8935-6-27.

5.

HDAC3 is essential for DNA replication in hematopoietic progenitor cells.

Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW.

J Clin Invest. 2013 Jul;123(7):3112-23. doi: 10.1172/JCI60806. Epub 2013 Jun 10.

6.

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD Jr, Xue F, Mason CE, Hiebert SW, Prive GG, Cerchietti L, Bardwell VJ, Elemento O, Melnick A.

Cell Rep. 2013 Aug 15;4(3):578-88. doi: 10.1016/j.celrep.2013.06.016. Epub 2013 Aug 1.

7.

Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma.

Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW.

PLoS One. 2013 Jul 22;8(7):e68915. doi: 10.1371/journal.pone.0068915. Print 2013.

8.

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M.

Nucleic Acids Res. 2013 Jan 7;41(1):90-109. doi: 10.1093/nar/gks916. Epub 2012 Oct 19.

9.

The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.

Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D.

Cancer Biol Ther. 2011 Sep 15;12(6):484-93. doi: 10.4161/cbt.12.6.15956. Epub 2011 Sep 15.

10.

Analysis of protein dynamics at active, stalled, and collapsed replication forks.

Sirbu BM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D.

Genes Dev. 2011 Jun 15;25(12):1320-7. doi: 10.1101/gad.2053211.

11.

Role for histone deacetylase 3 in maintenance of genome stability.

Bhaskara S, Hiebert SW.

Cell Cycle. 2011 Mar 1;10(5):727-8. Epub 2011 Mar 1. No abstract available.

12.

Hdac3 is essential for the maintenance of chromatin structure and genome stability.

Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW.

Cancer Cell. 2010 Nov 16;18(5):436-47. doi: 10.1016/j.ccr.2010.10.022.

13.

The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation.

Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW.

J Biol Chem. 2010 Aug 6;285(32):24548-61. doi: 10.1074/jbc.M110.117333. Epub 2010 Jun 9.

14.

Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.

Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW.

Mol Cell Biol. 2008 Oct;28(20):6234-47. doi: 10.1128/MCB.00404-08. Epub 2008 Aug 18.

15.

Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.

Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW.

Mol Cell. 2008 Apr 11;30(1):61-72. doi: 10.1016/j.molcel.2008.02.030.

16.

Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels.

Bhaskara S, Chandrasekharan MB, Ganguly R.

Gene. 2008 May 31;415(1-2):49-59. doi: 10.1016/j.gene.2008.02.017. Epub 2008 Mar 4.

PMID:
18395996
17.

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks.

Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW.

EMBO J. 2008 Apr 9;27(7):1017-28. doi: 10.1038/emboj.2008.51. Epub 2008 Mar 20.

18.
19.

Double-blind, placebo-controlled, crossover trial of clozapine plus glycine in refractory schizophrenia negative results.

Diaz P, Bhaskara S, Dursun SM, Deakin B.

J Clin Psychopharmacol. 2005 Jun;25(3):277-8. No abstract available.

PMID:
15876911
20.

From chlorpromazine to clozapine--antipsychotic adverse effects and the clinician's dilemma.

Abidi S, Bhaskara SM.

Can J Psychiatry. 2003 Dec;48(11):749-55. Review.

PMID:
14733456
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