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Postmortem Alzheimer's Disease Hippocampi Show Oxidative Phosphorylation Gene Expression Opposite that of Isolated Pyramidal Neurons.

Rice AC, Ladd AC, Bennett JP Jr.

J Alzheimers Dis. 2015 Jan 1;45(4):1051-9. doi: 10.3233/JAD-142937.


Mitochondrial oxidative phosphorylation transcriptome alterations in human amyotrophic lateral sclerosis spinal cord and blood.

Ladd AC, Keeney PM, Govind MM, Bennett JP Jr.

Neuromolecular Med. 2014 Dec;16(4):714-26. doi: 10.1007/s12017-014-8321-y. Epub 2014 Aug 1.


Mortality in levodopa-treated Parkinson's disease.

Morgan JC, Currie LJ, Harrison MB, Bennett JP Jr, Trugman JM, Wooten GF.

Parkinsons Dis. 2014;2014:426976. doi: 10.1155/2014/426976. Epub 2014 Jan 28.


Mitochondrial DNA copy numbers in pyramidal neurons are decreased and mitochondrial biogenesis transcriptome signaling is disrupted in Alzheimer's disease hippocampi.

Rice AC, Keeney PM, Algarzae NK, Ladd AC, Thomas RR, Bennett JP Jr.

J Alzheimers Dis. 2014;40(2):319-30. doi: 10.3233/JAD-131715.


Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression.

Cronin-Furman EN, Borland MK, Bergquist KE, Bennett JP Jr, Trimmer PA.

Mol Neurodegener. 2013 Jan 26;8:6. doi: 10.1186/1750-1326-8-6.


RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice.

Thomas RR, Khan SM, Smigrodzki RM, Onyango IG, Dennis J, Khan OM, Portelli FR, Bennett JP Jr.

Aging (Albany NY). 2012 Sep;4(9):620-35.


Mitochondrial gene therapy improves respiration, biogenesis, and transcription in G11778A Leber's hereditary optic neuropathy and T8993G Leigh's syndrome cells.

Iyer S, Bergquist K, Young K, Gnaiger E, Rao RR, Bennett JP Jr.

Hum Gene Ther. 2012 Jun;23(6):647-57. doi: 10.1089/hum.2011.177. Epub 2012 Apr 17.


Mitochondrial gene replacement in human pluripotent stem cell-derived neural progenitors.

Iyer S, Xiao E, Alsayegh K, Eroshenko N, Riggs MJ, Bennett JP Jr, Rao RR.

Gene Ther. 2012 May;19(5):469-75. doi: 10.1038/gt.2011.134. Epub 2011 Sep 15.


Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin.

Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr.

Mitochondrion. 2011 Jan;11(1):108-18. doi: 10.1016/j.mito.2010.08.004. Epub 2010 Aug 18.


Nerve growth factor attenuates oxidant-induced β-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids.

Onyango IG, Ahn JY, Tuttle JB, Bennett JP Jr, Swerdlow RH.

J Neurochem. 2010 Sep;114(6):1605-18. doi: 10.1111/j.1471-4159.2010.06871.x. Epub 2010 Jul 30.


ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions.

Keeney PM, Bennett JP Jr.

Mol Neurodegener. 2010 May 26;5:21. doi: 10.1186/1750-1326-5-21.


Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships.

Keeney PM, Dunham LD, Quigley CK, Morton SL, Bergquist KE, Bennett JP Jr.

Exp Neurol. 2009 Dec;220(2):374-82. doi: 10.1016/j.expneurol.2009.09.025. Epub 2009 Oct 6.


Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression.

Iyer S, Thomas RR, Portell FR, Dunham LD, Quigley CK, Bennett JP Jr.

Mitochondrion. 2009 Jun;9(3):196-203. doi: 10.1016/j.mito.2009.01.012. Epub 2009 Feb 4.


Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model.

Keeney PM, Quigley CK, Dunham LD, Papageorge CM, Iyer S, Thomas RR, Schwarz KM, Trimmer PA, Khan SM, Portell FR, Bergquist KE, Bennett JP Jr.

Hum Gene Ther. 2009 Aug;20(8):897-907. doi: 10.1089/hum.2009.023.


The cybrid model of sporadic Parkinson's disease.

Trimmer PA, Bennett JP Jr.

Exp Neurol. 2009 Aug;218(2):320-5. doi: 10.1016/j.expneurol.2009.03.016. Epub 2009 Mar 26. Review.


Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells.

Borland MK, Trimmer PA, Rubinstein JD, Keeney PM, Mohanakumar K, Liu L, Bennett JP Jr.

Mol Neurodegener. 2008 Dec 29;3:21. doi: 10.1186/1750-1326-3-21.


Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues.

Borland MK, Mohanakumar KP, Rubinstein JD, Keeney PM, Xie J, Capaldi R, Dunham LD, Trimmer PA, Bennett JP Jr.

Biochim Biophys Acta. 2009 Jan;1792(1):68-74. doi: 10.1016/j.bbadis.2008.09.014. Epub 2008 Oct 10.


R+ pramipexole as a mitochondrially focused neuroprotectant: initial early phase studies in ALS.

Wang H, Larriviere KS, Keller KE, Ware KA, Burns TM, Conaway MA, Lacomis D, Pattee GL, Phillips LH 2nd, Solenski NJ, Zivkovic SA, Bennett JP Jr.

Amyotroph Lateral Scler. 2008 Feb;9(1):50-8. doi: 10.1080/17482960701791234.

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