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Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease.

Toapanta FR, Bernal PJ, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ, Sztein MB.

PLoS Negl Trop Dis. 2016 Jun 14;10(6):e0004766. doi: 10.1371/journal.pntd.0004766. eCollection 2016 Jun.


Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.

Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS, Angus B, Zhou L, Hill J, Clare S, Kane L, Mukhopadhyay S, Schreiber F, Duque-Correa MA, Wright JC, Roumeliotis TI, Yu L, Choudhary JS, Mejias A, Ramilo O, Shanyinde M, Sztein MB, Kingsley RA, Lockhart S, Levine MM, Lynn DJ, Dougan G, Pollard AJ.

J Exp Med. 2016 May 30;213(6):1061-77. doi: 10.1084/jem.20151025. Epub 2016 May 23.


Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical Trial.

Milligan ID, Gibani MM, Sewell R, Clutterbuck EA, Campbell D, Plested E, Nuthall E, Voysey M, Silva-Reyes L, McElrath MJ, De Rosa SC, Frahm N, Cohen KW, Shukarev G, Orzabal N, van Duijnhoven W, Truyers C, Bachmayer N, Splinter D, Samy N, Pau MG, Schuitemaker H, Luhn K, Callendret B, Van Hoof J, Douoguih M, Ewer K, Angus B, Pollard AJ, Snape MD.

JAMA. 2016 Apr 19;315(15):1610-23. doi: 10.1001/jama.2016.4218.


Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans.

Fresnay S, McArthur MA, Magder L, Darton TC, Jones C, Waddington CS, Blohmke CJ, Angus B, Levine MM, Pollard AJ, Sztein MB.

J Transl Med. 2016 Mar 1;14:62. doi: 10.1186/s12967-016-0819-7.


Oral versus intravenous antibiotic treatment for bone and joint infections (OVIVA): study protocol for a randomised controlled trial.

Li HK, Scarborough M, Zambellas R, Cooper C, Rombach I, Walker AS, Lipsky BA, Briggs A, Seaton A, Atkins B, Woodhouse A, Berendt A, Byren I, Angus B, Pandit H, Stubbs D, McNally M, Thwaites G, Bejon P.

Trials. 2015 Dec 21;16:583. doi: 10.1186/s13063-015-1098-y.


Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults.

Green CA, Scarselli E, Sande CJ, Thompson AJ, de Lara CM, Taylor KS, Haworth K, Del Sorbo M, Angus B, Siani L, Di Marco S, Traboni C, Folgori A, Colloca S, Capone S, Vitelli A, Cortese R, Klenerman P, Nicosia A, Pollard AJ.

Sci Transl Med. 2015 Aug 12;7(300):300ra126. doi: 10.1126/scitranslmed.aac5745.


Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers.

McCullagh D, Dobinson HC, Darton T, Campbell D, Jones C, Snape M, Stevens Z, Plested E, Voysey M, Kerridge S, Martin LB, Angus B, Pollard AJ.

BMJ Open. 2015 Jun 16;5(6):e007481. doi: 10.1136/bmjopen-2014-007481.


Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

Toapanta FR, Bernal PJ, Fresnay S, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB.

PLoS Negl Trop Dis. 2015 Jun 11;9(6):e0003837. doi: 10.1371/journal.pntd.0003837. eCollection 2015 Jun.


Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.

McArthur MA, Fresnay S, Magder LS, Darton TC, Jones C, Waddington CS, Blohmke CJ, Dougan G, Angus B, Levine MM, Pollard AJ, Sztein MB.

PLoS Pathog. 2015 May 22;11(5):e1004914. doi: 10.1371/journal.ppat.1004914. eCollection 2015 May.


Misdiagnosis versus missed diagnosis: diagnosing autism spectrum disorder in adolescents.

Aggarwal S, Angus B.

Australas Psychiatry. 2015 Apr;23(2):120-3. doi: 10.1177/1039856214568214. Epub 2015 Feb 4.


Reply to Farmakiotis et al.

Waddington CS, Darton TC, Angus B, Pollard AJ.

Clin Infect Dis. 2014 Oct 15;59(8):1198-9. doi: 10.1093/cid/ciu561. Epub 2014 Jul 30. No abstract available.


Adverse events and deterioration reported by participants in the PACE trial of therapies for chronic fatigue syndrome.

Dougall D, Johnson A, Goldsmith K, Sharpe M, Angus B, Chalder T, White P.

J Psychosom Res. 2014 Jul;77(1):20-6. doi: 10.1016/j.jpsychores.2014.04.002. Epub 2014 Apr 22.


Novel anti-malarial combinations and their toxicity.

Angus B.

Expert Rev Clin Pharmacol. 2014 May;7(3):299-316. doi: 10.1586/17512433.2014.907523. Epub 2014 Apr 9. Review.


An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.

Waddington CS, Darton TC, Jones C, Haworth K, Peters A, John T, Thompson BA, Kerridge SA, Kingsley RA, Zhou L, Holt KE, Yu LM, Lockhart S, Farrar JJ, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ.

Clin Infect Dis. 2014 May;58(9):1230-40. doi: 10.1093/cid/ciu078. Epub 2014 Feb 10.


Advancing the management and control of typhoid fever: a review of the historical role of human challenge studies.

Waddington CS, Darton TC, Woodward WE, Angus B, Levine MM, Pollard AJ.

J Infect. 2014 May;68(5):405-18. doi: 10.1016/j.jinf.2014.01.006. Epub 2014 Jan 31. Review.


Understanding the investigators: a qualitative study investigating the barriers and enablers to the implementation of local investigator-initiated clinical trials in Ethiopia.

Franzen SR, Chandler C, Enquselassie F, Siribaddana S, Atashili J, Angus B, Lang T.

BMJ Open. 2013 Nov 27;3(11):e003616. doi: 10.1136/bmjopen-2013-003616.


Cost-effectiveness of newer antiretroviral drugs in treatment-experienced patients with multidrug-resistant HIV disease.

Bayoumi AM, Barnett PG, Joyce VR, Griffin SC, Sun H, Bansback NJ, Holodniy M, Sanders G, Brown ST, Kyriakides TC, Angus B, Cameron DW, Anis AH, Sculpher M, Owens DK.

J Acquir Immune Defic Syndr. 2013 Dec 1;64(4):382-91. doi: 10.1097/QAI.0000000000000002.


Prognostic significance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B cell lymphoma patients.

Culpin RE, Sieniawski M, Angus B, Menon GK, Proctor SJ, Milne P, McCabe K, Mainou-Fowler T.

Histopathology. 2013 Dec;63(6):788-801. doi: 10.1111/his.12223. Epub 2013 Oct 1.


Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection.

Clutton G, Yang H, Hancock G, Sande N, Holloway C, Angus B, von Delft A, Barnes E, Borrow P, Pellegrino P, Williams I, McMichael A, Dorrell L.

Eur J Immunol. 2013 Nov;43(11):2875-85. doi: 10.1002/eji.201343646. Epub 2013 Aug 29.


Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand.

Newton PN, Stepniewska K, Dondorp A, Silamut K, Chierakul W, Krishna S, Davis TM, Suputtamongkol Y, Angus B, Pukrittayakamee S, Ruangveerayuth R, Hanson J, Day NP, White NJ.

Malar J. 2013 Jul 8;12:229. doi: 10.1186/1475-2875-12-229.

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