The effects of the genetic absence and inhibition of CYP2D6 on the metabolism of codeine and its derivatives, hydrocodone and oxycodone

Anesth Prog. 1998 Fall;45(4):154-6.

Author

G Lurcott¹

Affiliation

¹ School of Dentistry, University of Michigan, Ann Arbor, USA.

PMID: 10483388
PMCID: PMC2148980

No abstract available

Publication types

Review

MeSH terms

Analgesics, Opioid / antagonists & inhibitors
Analgesics, Opioid / metabolism*
Anti-Arrhythmia Agents / metabolism
Binding, Competitive
Codeine / antagonists & inhibitors
Codeine / metabolism*
Cytochrome P-450 CYP2D6 / deficiency*
Cytochrome P-450 CYP2D6 / genetics
Cytochrome P-450 CYP2D6 / metabolism
Cytochrome P-450 CYP2D6 Inhibitors*
Enzyme Inhibitors / metabolism
Fluoxetine / metabolism
Humans
Hydrocodone / antagonists & inhibitors
Hydrocodone / metabolism
Oxycodone / antagonists & inhibitors
Oxycodone / metabolism
Paroxetine / metabolism
Quinidine / metabolism
Selective Serotonin Reuptake Inhibitors / metabolism

Substances

Analgesics, Opioid
Anti-Arrhythmia Agents
Cytochrome P-450 CYP2D6 Inhibitors
Enzyme Inhibitors
Serotonin Uptake Inhibitors
Fluoxetine
Paroxetine
Hydrocodone
Oxycodone
Cytochrome P-450 CYP2D6
Quinidine
Codeine