Transplantation of conjunctival limbal autograft and amniotic membrane vs mitomycin C and amniotic membrane in treatment of recurrent pterygium

Eye (Lond). 2008 Mar;22(3):420-4. doi: 10.1038/sj.eye.6702657. Epub 2006 Dec 8.

Abstract

Aim: To compare the efficacy and complications of conjunctival limbal autograft (CLAU) and amniotic membrane transplantation (AMT) vsintraoperative mitomycin C (MMC) and AMT for treatment of recurrent pterygium.

Methods: Forty eyes of 40 patients with recurrent pterygium underwent CLAU and AMT (20 eyes) or intraoperative MMC (0.02%, 3 min) and AMT (20 eyes). Three eyes (15%) had symblepharon before surgery in each group. Recurrence was compared in each group by using chi(2) test.

Results: No major postoperative complications occurred during 6-19 months of follow-up. In CLAU/AMT group, no pterygium recurrence was observed. Recurrence occurred in four eyes (20%) in MMC/AMT group after 3 and 4 months (P-value=0.035, chi(2) test). No recurrence of pterygium or symblepharon was seen in six eyes with recurrent pterygium and symblepharon (three eyes in each group).

Conclusion: CLAU with AMT seems to be more effective than intraoperative MMC with AMT for treatment of recurrent pterygium.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amnion / transplantation*
  • Chi-Square Distribution
  • Conjunctiva / transplantation*
  • Female
  • Humans
  • Limbus Corneae / surgery*
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage*
  • Postoperative Complications
  • Pterygium* / drug therapy
  • Pterygium* / surgery
  • Recurrence
  • Treatment Outcome

Substances

  • Mitomycin