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CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6.

Al-Rakan MA, Hendrayani SF, Aboussekhra A.

BMC Cancer. 2016 Aug 2;16:575. doi: 10.1186/s12885-016-2614-5.


PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells.

Al-Howail HA, Hakami HA, Al-Otaibi B, Al-Mazrou A, Daghestani MH, Al-Jammaz I, Al-Khalaf HH, Aboussekhra A.

BMC Cancer. 2016 Jul 27;16:540. doi: 10.1186/s12885-016-2583-8.


The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts.

Hendrayani SF, Al-Harbi B, Al-Ansari MM, Silva G, Aboussekhra A.

Oncotarget. 2016 May 26. doi: 10.18632/oncotarget.9633. [Epub ahead of print]


Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh.

Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS.

Sci Rep. 2016 Jan 5;6:18830. doi: 10.1038/srep18830.


miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts.

Al-Ansari MM, Aboussekhra A.

Oncotarget. 2015 Oct 6;6(30):30006-16. doi: 10.18632/oncotarget.4933.


p16(INK4A) inhibits the pro-metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF-β1.

Silva G, Aboussekhra A.

Mol Carcinog. 2016 May;55(5):525-36. doi: 10.1002/mc.22299. Epub 2015 Mar 1.


PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.

Al-Qasem A, Al-Howail HA, Al-Swailem M, Al-Mazrou A, Al-Otaibi B, Al-Jammaz I, Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2016 Mar;55(3):233-44. doi: 10.1002/mc.22271. Epub 2015 Jan 16.


The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.

Al-Moghrabi N, Nofel A, Al-Yousef N, Madkhali S, Bin Amer SM, Alaiya A, Shinwari Z, Al-Tweigeri T, Karakas B, Tulbah A, Aboussekhra A.

BMC Cancer. 2014 Nov 17;14:830. doi: 10.1186/1471-2407-14-830.


Obesity is a significant risk factor for breast cancer in Arab women.

Elkum N, Al-Tweigeri T, Ajarim D, Al-Zahrani A, Amer SM, Aboussekhra A.

BMC Cancer. 2014 Oct 29;14:788. doi: 10.1186/1471-2407-14-788.


The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1.

Hendrayani SF, Al-Khalaf HH, Aboussekhra A.

J Biol Chem. 2014 Nov 7;289(45):30962-76. doi: 10.1074/jbc.M114.594044. Epub 2014 Sep 17.


Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes.

Al-Ansari MM, Aboussekhra A.

PLoS One. 2014 Mar 3;9(3):e90907. doi: 10.1371/journal.pone.0090907. eCollection 2014.


Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation.

Al-Sharif I, Remmal A, Aboussekhra A.

BMC Cancer. 2013 Dec 13;13:600. doi: 10.1186/1471-2407-13-600.


Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic.

Al-Rakan MA, Colak D, Hendrayani SF, Al-Bakheet A, Al-Mohanna FH, Kaya N, Al-Malik O, Aboussekhra A.

J Pathol. 2013 Dec;231(4):457-65. doi: 10.1002/path.4256.


Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients.

Karakas B, Colak D, Kaya N, Ghebeh H, Al-Qasem A, Hendrayani F, Toulimat M, Al-Tweigeri T, Park BH, Aboussekhra A.

Cancer Biol Ther. 2013 Oct 1;14(10):888-96. doi: 10.4161/cbt.25945. Epub 2013 Aug 12.


p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.

Al-Khalaf HH, Aboussekhra A.

PLoS One. 2013 Jul 23;8(7):e70133. doi: 10.1371/journal.pone.0070133. Print 2013.


ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner.

Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2014 Dec;53(12):979-87. doi: 10.1002/mc.22066. Epub 2013 Jun 29.


p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition.

Al-Ansari MM, Hendrayani SF, Tulbah A, Al-Tweigeri T, Shehata AI, Aboussekhra A.

Neoplasia. 2012 Dec;14(12):1269-77.

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