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Items: 1 to 20 of 42

1.

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M.

Genes Dev. 1999 Jan 1;13(1):76-86.

2.

Regulatory mechanisms of cellular response to oxidative stress.

Itoh K, Ishii T, Wakabayashi N, Yamamoto M.

Free Radic Res. 1999 Oct;31(4):319-24. Review.

PMID:
10517536
3.

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.

Itoh K, Tong KI, Yamamoto M.

Free Radic Biol Med. 2004 May 15;36(10):1208-13. Review.

PMID:
15110385
4.

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.

Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M.

Arch Biochem Biophys. 2005 Jan 15;433(2):342-50. Review.

PMID:
15581590
5.

Discovery of the negative regulator of Nrf2, Keap1: a historical overview.

Itoh K, Mimura J, Yamamoto M.

Antioxid Redox Signal. 2010 Dec 1;13(11):1665-78. doi: 10.1089/ars.2010.3222. Epub 2010 Jul 13. Review.

PMID:
20446768
6.

Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.

Kobayashi A, Ohta T, Yamamoto M.

Methods Enzymol. 2004;378:273-86. Review. No abstract available.

PMID:
15038975
7.

Nrf2-Keap1 defines a physiologically important stress response mechanism.

Motohashi H, Yamamoto M.

Trends Mol Med. 2004 Nov;10(11):549-57. Review.

PMID:
15519281
8.

Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents.

Giudice A, Arra C, Turco MC.

Methods Mol Biol. 2010;647:37-74. doi: 10.1007/978-1-60761-738-9_3. Review.

PMID:
20694660
9.

Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers.

Kwak MK, Wakabayashi N, Kensler TW.

Mutat Res. 2004 Nov 2;555(1-2):133-48. Review.

PMID:
15476857
10.

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress.

Nguyen T, Yang CS, Pickett CB.

Free Radic Biol Med. 2004 Aug 15;37(4):433-41. Review.

PMID:
15256215
11.

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation.

Kobayashi M, Yamamoto M.

Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):385-94. Review.

PMID:
15706085
12.

Nrf2 as a novel molecular target for chemoprevention.

Lee JS, Surh YJ.

Cancer Lett. 2005 Jun 28;224(2):171-84. Epub 2004 Nov 11. Review.

PMID:
15914268
13.

Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia.

Mann GE, Niehueser-Saran J, Watson A, Gao L, Ishii T, de Winter P, Siow RC.

Sheng Li Xue Bao. 2007 Apr 25;59(2):117-27. Review.

14.

Nrf2 signaling in coordinated activation of antioxidant gene expression.

Jaiswal AK.

Free Radic Biol Med. 2004 May 15;36(10):1199-207. Review.

PMID:
15110384
15.

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress.

Nguyen T, Nioi P, Pickett CB.

J Biol Chem. 2009 May 15;284(20):13291-5. doi: 10.1074/jbc.R900010200. Epub 2009 Jan 30. Review.

16.

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

Nguyen T, Sherratt PJ, Pickett CB.

Annu Rev Pharmacol Toxicol. 2003;43:233-60. Epub 2002 Jan 10. Review.

PMID:
12359864
17.

Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases.

Saito H.

Biochem Pharmacol. 2013 Apr 1;85(7):865-72. doi: 10.1016/j.bcp.2013.01.006. Epub 2013 Jan 17. Review.

PMID:
23333765
18.

Regulation of Nrf2-an update.

Niture SK, Khatri R, Jaiswal AK.

Free Radic Biol Med. 2014 Jan;66:36-44. doi: 10.1016/j.freeradbiomed.2013.02.008. Epub 2013 Feb 19. Review.

19.

Keap1-Nrf2 signaling pathway: mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles.

Turpaev KT.

Biochemistry (Mosc). 2013 Feb;78(2):111-26. doi: 10.1134/S0006297913020016. Review.

PMID:
23581983
20.

Nrf2 signaling and cell survival.

Niture SK, Kaspar JW, Shen J, Jaiswal AK.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):37-42. doi: 10.1016/j.taap.2009.06.009. Epub 2009 Jun 16. Review.

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