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Atherosclerosis. 2013 Jul;229(1):212-6. doi: 10.1016/j.atherosclerosis.2013.04.012. Epub 2013 Apr 18.

Hypertension in pregnancy is a risk factor for peripheral arterial disease decades after pregnancy.

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  • 1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, RO-MA-19-E19NEP, Rochester, MN 55905, USA.

Abstract

BACKGROUND:

An ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value ≤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI ≤0.9 decades after pregnancy.

METHODS AND RESULTS:

ABI was measured in nulliparous women (n = 144), and women with a history of normotensive (n = 1272) or hypertensive (n = 281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean) ± 10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p = 0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p = 0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p = 0.87).

CONCLUSIONS:

Hypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.

Copyright © 2013. Published by Elsevier Ireland Ltd.

PMID:
23659871
[PubMed - indexed for MEDLINE]
PMCID:
PMC3694211
Free PMC Article
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