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Sao Paulo Med J. 2013;131(2):100-5.

Carotid intima-media thickness in spondyloarthritis patients.

Author information

  • 1Rheumatology and Echocardiography Units, Hospital Universitário Evangélico de Curitiba, Curitiba, Paraná, Brazil. tskare@onda.com.br

Abstract

CONTEXT AND OBJECTIVE:

Accelerated atherosclerosis has become a major problem in rheumatic inflammatory disease. The aim here was to analyze carotid intima-media thickness (IMT) in spondyloarthritis (SpA) patients and correlate this with clinical parameters and inflammatory markers.

DESIGN AND SETTING:

Cross-sectional analytical study at Rheumatology Outpatient Clinic, Evangelical University Hospital, Curitiba.

METHODS:

IMTs (measured using Doppler ultrasonography) of 36 SpA patients were compared with controls. The IMT in SpA patients was associated with inflammatory markers, like erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); and with clinical parameters, like axial or peripheral involvement, dactylitis, HLA B27, uveitis occurrence, Bath Ankylosing Spondylitis Functional Index (BASFI) and lipid profile.

RESULTS:

The mean IMT in SpA patients was 0.72 ± 0.21 mm; in controls, 0.57 ± 0.13 mm (P = 0.0007). There were no associations with ESR, CRP, BASDAI or clinical data. In univariate analysis, greater IMT was seen in patients with longer disease duration (P = 0.014; Pearson R = 0.40; 95% confidence interval, CI = 0.06 to 0.65); higher triglycerides (P = 0.02; Spearman R = 0.37; 95% CI = 0.03 to 0.64); and older age (P = 0.0014; Pearson R 0.51; 95% CI = 0.21 to 0.72).

CONCLUSION:

SpA patients have a higher degree of subclinical atherosclerosis than in controls, thus supporting clinical evidence of increased cardiovascular risk in rheumatic patients.

PMID:
23657512
[PubMed - indexed for MEDLINE]
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