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Bioinformation. 2012;8(20):1000-2. doi: 10.6026/97320630081000. Epub 2012 Oct 13.

DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase.

Author information

  • 1Department of Biochemistry & Biophysics, University of Kalyani, Kalyani, Dt. - Nadia, West Bengal, India.

Abstract

Dehydrogenase enzymes are almost inevitable for metabolic processes. Shortage or malfunctioning of dehydrogenases often leads to several acute diseases like cancers, retinal diseases, diabetes mellitus, Alzheimer, hepatitis B & C etc. With advancement in modern-day research, huge amount of sequential, structural and functional data are generated everyday and widens the gap between structural attributes and its functional understanding. DB Dehydrogenase is an effort to relate the functionalities of dehydrogenase with its structures. It is a completely web-based structural database, covering almost all dehydrogenases [~150 enzyme classes, ~1200 entries from ~160 organisms] whose structures are known. It is created by extracting and integrating various online resources to provide the true and reliable data and implemented by MySQL relational database through user friendly web interfaces using CGI Perl. Flexible search options are there for data extraction and exploration. To summarize, sequence, structure, function of all dehydrogenases in one place along with the necessary option of cross-referencing; this database will be utile for researchers to carry out further work in this field.

AVAILABILITY:

The database is available for free at http://www.bifku.in/DBD/

KEYWORDS:

Annotation; Database; Dehydrogenase; Oxidoreductase; Structure

PMID:
23275696
[PubMed]
PMCID:
PMC3524946
Free PMC Article

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