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Results: 1 to 20 of 31

1.

Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions.

Sedykh A, Fourches D, Duan J, Hucke O, Garneau M, Zhu H, Bonneau P, Tropsha A.

Pharm Res. 2013 Apr;30(4):996-1007. doi: 10.1007/s11095-012-0935-x. Epub 2012 Dec 27.

PMID:
23269503
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Targeting intestinal transporters for optimizing oral drug absorption.

Varma MV, Ambler CM, Ullah M, Rotter CJ, Sun H, Litchfield J, Fenner KS, El-Kattan AF.

Curr Drug Metab. 2010 Nov;11(9):730-42. Review.

PMID:
21189135
[PubMed - indexed for MEDLINE]
3.

Predictive QSAR modeling workflow, model applicability domains, and virtual screening.

Tropsha A, Golbraikh A.

Curr Pharm Des. 2007;13(34):3494-504. Review.

PMID:
18220786
[PubMed - indexed for MEDLINE]
4.

Implications of the dominant role of transporters in drug uptake by cells.

Dobson PD, Lanthaler K, Oliver SG, Kell DB.

Curr Top Med Chem. 2009;9(2):163-81. Review.

PMID:
19200003
[PubMed - indexed for MEDLINE]
5.

Animal models and intestinal drug transport.

Glaeser H, Fromm MF.

Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):347-61. doi: 10.1517/17425255.4.4.347 . Review.

PMID:
18433341
[PubMed - indexed for MEDLINE]
6.

Computational approaches to modeling drug transporters.

Chang C, Swaan PW.

Eur J Pharm Sci. 2006 Apr;27(5):411-24. Epub 2005 Nov 4. Review.

PMID:
16274971
[PubMed - indexed for MEDLINE]
7.

High-throughput and in silico techniques in drug metabolism and pharmacokinetics.

van de Waterbeemd H.

Curr Opin Drug Discov Devel. 2002 Jan;5(1):33-43. Review.

PMID:
11865671
[PubMed - indexed for MEDLINE]
8.

Structure-based drug screening and ligand-based drug screening with machine learning.

Fukunishi Y.

Comb Chem High Throughput Screen. 2009 May;12(4):397-408. Review.

PMID:
19442067
[PubMed - indexed for MEDLINE]
9.

Predicting ligand interactions with ABC transporters in ADME.

Demel MA, Krämer O, Ettmayer P, Haaksma EE, Ecker GF.

Chem Biodivers. 2009 Nov;6(11):1960-9. doi: 10.1002/cbdv.200900138. Review.

PMID:
19937827
[PubMed - indexed for MEDLINE]
10.

[Intestinal absorption and renal excretion mediated by transporters and the relationship with drug-drug interaction].

Zhang J, Liu KX.

Yao Xue Xue Bao. 2010 Sep;45(9):1089-94. Review. Chinese.

PMID:
21351563
[PubMed - indexed for MEDLINE]
11.

Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions.

Grandvuinet AS, Vestergaard HT, Rapin N, Steffansen B.

J Pharm Pharmacol. 2012 Nov;64(11):1523-48. doi: 10.1111/j.2042-7158.2012.01505.x. Epub 2012 Mar 30. Review.

PMID:
23058041
[PubMed - indexed for MEDLINE]
12.

The use of machine learning and nonlinear statistical tools for ADME prediction.

Sakiyama Y.

Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):149-69. doi: 10.1517/17425250902753261 . Review.

PMID:
19239395
[PubMed - indexed for MEDLINE]
13.

On various metrics used for validation of predictive QSAR models with applications in virtual screening and focused library design.

Roy K, Mitra I.

Comb Chem High Throughput Screen. 2011 Jul;14(6):450-74. Review.

PMID:
21521150
[PubMed - indexed for MEDLINE]
14.

Receptor dependent multidimensional QSAR for modeling drug--receptor interactions.

Polanski J.

Curr Med Chem. 2009;16(25):3243-57. Epub 2009 Sep 1. Review.

PMID:
19548875
[PubMed - indexed for MEDLINE]
15.

Predictive QSAR modeling for the successful predictions of the ADMET properties of candidate drug molecules.

Khan MT, Sylte I.

Curr Drug Discov Technol. 2007 Oct;4(3):141-9. Review.

PMID:
17985997
[PubMed - indexed for MEDLINE]
16.

Recent developments of in silico predictions of intestinal absorption and oral bioavailability.

Hou T, Li Y, Zhang W, Wang J.

Comb Chem High Throughput Screen. 2009 Jun;12(5):497-506. Review.

PMID:
19519329
[PubMed - indexed for MEDLINE]
17.

Machine learning techniques and drug design.

Gertrudes JC, Maltarollo VG, Silva RA, Oliveira PR, Honório KM, da Silva AB.

Curr Med Chem. 2012;19(25):4289-97. Review.

PMID:
22830342
[PubMed - indexed for MEDLINE]
18.

Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.

Chu X, Korzekwa K, Elsby R, Fenner K, Galetin A, Lai Y, Matsson P, Moss A, Nagar S, Rosania GR, Bai JP, Polli JW, Sugiyama Y, Brouwer KL; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):126-41. doi: 10.1038/clpt.2013.78. Epub 2013 Apr 10. Review.

PMID:
23588320
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters.

Kusuhara H, Sugiyama Y.

Drug Metab Rev. 2010 Aug;42(3):539-50. doi: 10.3109/03602530903491824. Review.

PMID:
20175646
[PubMed - indexed for MEDLINE]
20.

Considerations and recent advances in QSAR models for cytochrome P450-mediated drug metabolism prediction.

Li H, Sun J, Fan X, Sui X, Zhang L, Wang Y, He Z.

J Comput Aided Mol Des. 2008 Nov;22(11):843-55. doi: 10.1007/s10822-008-9225-4. Epub 2008 Jun 24. Review.

PMID:
18574695
[PubMed - indexed for MEDLINE]

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