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Items: 1 to 20 of 76

1.

Identification of new epilepsy treatments: issues in preclinical methodology.

Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M; American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Working Group On Recommendations For Preclinical Epilepsy Drug Discovery.

Epilepsia. 2012 Mar;53(3):571-82. doi: 10.1111/j.1528-1167.2011.03391.x. Epub 2012 Jan 31. Review.

2.

The challenge and promise of anti-epileptic therapy development in animal models.

Simonato M, Brooks-Kayal AR, Engel J Jr, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA.

Lancet Neurol. 2014 Sep;13(9):949-60. doi: 10.1016/S1474-4422(14)70076-6. Epub 2014 Aug 10. Review. Erratum in: Lancet Neurol. 2015 Jul;14(7):677.

3.

Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma.

Löscher W, Schmidt D.

Epilepsia. 2011 Apr;52(4):657-78. doi: 10.1111/j.1528-1167.2011.03024.x. Epub 2011 Mar 22. Review.

4.

Epilepsy therapy development: technical and methodologic issues in studies with animal models.

Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Dudek FE.

Epilepsia. 2013 Aug;54 Suppl 4:13-23. doi: 10.1111/epi.12295. Review.

5.

Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design.

Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J Jr, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H.

Epilepsia. 2012 Nov;53(11):1860-7. doi: 10.1111/j.1528-1167.2012.03541.x. Epub 2012 Jun 18. Review.

6.

Issues for new antiepilepsy drug development.

Simonato M, French JA, Galanopoulou AS, O'Brien TJ.

Curr Opin Neurol. 2013 Apr;26(2):195-200. doi: 10.1097/WCO.0b013e32835efe29. Review.

7.

Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy.

Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE.

Epilepsia. 2013 Aug;54 Suppl 4:44-60. doi: 10.1111/epi.12298. Review.

8.

Development of new treatment approaches for epilepsy: unmet needs and opportunities.

French JA, White HS, Klitgaard H, Holmes GL, Privitera MD, Cole AJ, Quay E, Wiebe S, Schmidt D, Porter RJ, Arzimanoglou A, Trinka E, Perucca E.

Epilepsia. 2013 Aug;54 Suppl 4:3-12. doi: 10.1111/epi.12294. Review.

9.

New avenues for anti-epileptic drug discovery and development.

Löscher W, Klitgaard H, Twyman RE, Schmidt D.

Nat Rev Drug Discov. 2013 Oct;12(10):757-76. doi: 10.1038/nrd4126. Epub 2013 Sep 20. Review.

PMID:
24052047
10.

Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development.

O'Brien TJ, Ben-Menachem E, Bertram EH 3rd, Collins SD, Kokaia M, Lerche H, Klitgaard H, Staley KJ, Vaudano E, Walker MC, Simonato M.

Epilepsia. 2013 Aug;54 Suppl 4:70-4. doi: 10.1111/epi.12300. Review.

11.

New strategies for the identification of drugs to prevent the development or progression of epilepsy.

Schmidt D, Rogawski MA.

Epilepsy Res. 2002 Jun;50(1-2):71-8. Review.

PMID:
12151119
12.

Disease modification in epilepsy: from animal models to clinical applications.

Barker-Haliski ML, Friedman D, French JA, White HS.

Drugs. 2015 May;75(7):749-67. doi: 10.1007/s40265-015-0395-9. Review.

PMID:
25925798
13.

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs.

Löscher W.

Seizure. 2011 Jun;20(5):359-68. doi: 10.1016/j.seizure.2011.01.003. Epub 2011 Feb 2. Review.

14.

Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?

Vezzani A.

Expert Opin Drug Saf. 2015 Apr;14(4):583-92. doi: 10.1517/14740338.2015.1010508. Epub 2015 Feb 3. Review.

PMID:
25645535
15.

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies.

Löscher W.

Epilepsy Res. 2016 Oct;126:157-84. doi: 10.1016/j.eplepsyres.2016.05.016. Epub 2016 Aug 1. Review.

PMID:
27505294
16.

New visions in the pharmacology of anticonvulsion.

Löscher W.

Eur J Pharmacol. 1998 Jan 19;342(1):1-13. Review.

PMID:
9544786
17.

What new modeling approaches will help us identify promising drug treatments?

Baraban SC, Löscher W.

Adv Exp Med Biol. 2014;813:283-94. doi: 10.1007/978-94-017-8914-1_23. Review.

PMID:
25012385
18.

Key factors in the discovery and development of new antiepileptic drugs.

Bialer M, White HS.

Nat Rev Drug Discov. 2010 Jan;9(1):68-82. doi: 10.1038/nrd2997. Review.

PMID:
20043029
19.

Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research.

Löscher W, Brandt C.

Pharmacol Rev. 2010 Dec;62(4):668-700. doi: 10.1124/pr.110.003046. Review.

20.

Sleep and epilepsy: exploring an intriguing relationship with a translational approach.

Matos G, Tufik S, Scorza FA, Cavalheiro EA, Andersen ML.

Epilepsy Behav. 2013 Mar;26(3):405-9. doi: 10.1016/j.yebeh.2012.12.003. Epub 2013 Feb 6. Review.

PMID:
23394796
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