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Items: 1 to 20 of 52

1.

Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin.

Olson SD, Kambal A, Pollock K, Mitchell GM, Stewart H, Kalomoiris S, Cary W, Nacey C, Pepper K, Nolta JA.

Mol Cell Neurosci. 2012 Mar;49(3):271-81. doi: 10.1016/j.mcn.2011.12.001. Epub 2011 Dec 8.

2.

RNAi-based therapies for Huntington's disease: delivery challenges and opportunities.

Mantha N, Das SK, Das NG.

Ther Deliv. 2012 Sep;3(9):1061-76. Review.

PMID:
23035592
3.

Delivering a disease-modifying treatment for Huntington's disease.

Godinho BM, Malhotra M, O'Driscoll CM, Cryan JF.

Drug Discov Today. 2015 Jan;20(1):50-64. doi: 10.1016/j.drudis.2014.09.011. Epub 2014 Sep 26. Review.

PMID:
25256777
4.

Viral-mediated overexpression of mutant huntingtin to model HD in various species.

Ruiz M, Déglon N.

Neurobiol Dis. 2012 Nov;48(2):202-11. doi: 10.1016/j.nbd.2011.08.023. Epub 2011 Aug 25. Review.

PMID:
21889981
5.

Huntington's disease: from pathology and genetics to potential therapies.

Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC.

Biochem J. 2008 Jun 1;412(2):191-209. doi: 10.1042/BJ20071619. Review.

PMID:
18466116
6.

Mechanisms of neuronal cell death in Huntington's disease.

Sawa A, Tomoda T, Bae BI.

Cytogenet Genome Res. 2003;100(1-4):287-95. Review.

PMID:
14526190
7.

Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease.

Olson SD, Pollock K, Kambal A, Cary W, Mitchell GM, Tempkin J, Stewart H, McGee J, Bauer G, Kim HS, Tempkin T, Wheelock V, Annett G, Dunbar G, Nolta JA.

Mol Neurobiol. 2012 Feb;45(1):87-98. doi: 10.1007/s12035-011-8219-8. Epub 2011 Dec 9. Review.

8.

Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease.

Bithell A, Johnson R, Buckley NJ.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1270-5. doi: 10.1042/BST0371270. Review.

PMID:
19909260
9.

Huntington's disease.

Roze E, Bonnet C, Betuing S, Caboche J.

Adv Exp Med Biol. 2010;685:45-63. Review.

PMID:
20687494
10.

Experimental surgical therapies for Huntington's disease.

Demeestere J, Vandenberghe W.

CNS Neurosci Ther. 2011 Dec;17(6):705-13. doi: 10.1111/j.1755-5949.2010.00209.x. Epub 2010 Dec 28. Review.

PMID:
21199443
11.

Huntington's disease: the past, present, and future search for disease modifiers.

Clabough EB.

Yale J Biol Med. 2013 Jun 13;86(2):217-33. Print 2013 Jun. Review.

12.

Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing.

Aronin N, DiFiglia M.

Mov Disord. 2014 Sep 15;29(11):1455-61. doi: 10.1002/mds.26020. Epub 2014 Aug 27. Review.

PMID:
25164989
13.

[Gene silencing approaches for the treatment of Huntington's disease].

Merienne N, Déglon N.

Med Sci (Paris). 2015 Feb;31(2):159-67. doi: 10.1051/medsci/20153102012. Epub 2015 Mar 4. Review. French.

14.

Huntington's disease: an update of therapeutic strategies.

Kumar A, Kumar Singh S, Kumar V, Kumar D, Agarwal S, Rana MK.

Gene. 2015 Feb 10;556(2):91-7. doi: 10.1016/j.gene.2014.11.022. Epub 2014 Nov 12. Review.

PMID:
25447911
15.

Neurobiology of Huntington's Disease.

De Souza RA, Leavitt BR.

Curr Top Behav Neurosci. 2015;22:81-100. doi: 10.1007/7854_2014_353. Review.

PMID:
25205327
16.

Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.

Bard J, Wall MD, Lazari O, Arjomand J, Munoz-Sanjuan I.

J Biomol Screen. 2014 Feb;19(2):191-204. doi: 10.1177/1087057113510320. Epub 2013 Nov 6. Review.

PMID:
24196395
17.

Targeting mutant huntingtin for the development of disease-modifying therapy.

Appl T, Kaltenbach L, Lo DC, Terstappen GC.

Drug Discov Today. 2012 Nov;17(21-22):1217-23. doi: 10.1016/j.drudis.2012.06.017. Epub 2012 Jul 4. Review.

18.

Degradation of misfolded proteins by autophagy: is it a strategy for Huntington's disease treatment?

Lin F, Qin ZH.

J Huntingtons Dis. 2013;2(2):149-57. doi: 10.3233/JHD-130052. Review.

PMID:
25063512
19.

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture.

Zhang X, Abels ER, Redzic JS, Margulis J, Finkbeiner S, Breakefield XO.

Cell Mol Neurobiol. 2016 Apr;36(3):459-70. doi: 10.1007/s10571-016-0350-7. Epub 2016 Mar 7. Review.

PMID:
26951563
20.

Therapeutic Strategies for Huntington's Disease.

Mrzljak L, Munoz-Sanjuan I.

Curr Top Behav Neurosci. 2015;22:161-201. doi: 10.1007/7854_2013_250. Review.

PMID:
24277342
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