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Results: 13

1.

The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

Tamble CM, St Onge RP, Giaever G, Nislow C, Williams AG, Stuart JM, Lokey RS.

Mol Biosyst. 2011 Jun;7(6):2019-30. doi: 10.1039/c0mb00298d. Epub 2011 Apr 12.

PMID:
21487606
[PubMed - indexed for MEDLINE]
2.

Chemical-genetic approaches for exploring the mode of action of natural products.

Lopez A, Parsons AB, Nislow C, Giaever G, Boone C.

Prog Drug Res. 2008;66:237, 239-71. Review.

PMID:
18416308
[PubMed - indexed for MEDLINE]
3.

Target identification and mechanism of action in chemical biology and drug discovery.

Schenone M, Dančík V, Wagner BK, Clemons PA.

Nat Chem Biol. 2013 Apr;9(4):232-40. doi: 10.1038/nchembio.1199. Review.

PMID:
23508189
[PubMed - indexed for MEDLINE]
4.

Small-molecule discovery from DNA-encoded chemical libraries.

Kleiner RE, Dumelin CE, Liu DR.

Chem Soc Rev. 2011 Dec;40(12):5707-17. doi: 10.1039/c1cs15076f. Epub 2011 Jun 14. Review.

PMID:
21674077
[PubMed - indexed for MEDLINE]
5.

Chemogenomics and biotechnology.

Wuster A, Madan Babu M.

Trends Biotechnol. 2008 May;26(5):252-8. doi: 10.1016/j.tibtech.2008.01.004. Epub 2008 Mar 17. Review.

PMID:
18346803
[PubMed - indexed for MEDLINE]
6.

Xenopus: an ideal system for chemical genetics.

Wheeler GN, Liu KJ.

Genesis. 2012 Mar;50(3):207-18. doi: 10.1002/dvg.22009. Epub 2012 Feb 16. Review.

PMID:
22344814
[PubMed - indexed for MEDLINE]
7.

Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways.

Enserink JM.

Molecules. 2012 Aug 2;17(8):9258-73. doi: 10.3390/molecules17089258. Review.

PMID:
22858845
[PubMed - indexed for MEDLINE]
Free Article
8.

High-throughput metabolic engineering: advances in small-molecule screening and selection.

Dietrich JA, McKee AE, Keasling JD.

Annu Rev Biochem. 2010;79:563-90. doi: 10.1146/annurev-biochem-062608-095938. Review.

PMID:
20367033
[PubMed - indexed for MEDLINE]
9.

Construction of a natural product library containing secondary metabolites produced by actinomycetes.

Takagi M, Shin-Ya K.

J Antibiot (Tokyo). 2012 Sep;65(9):443-7. doi: 10.1038/ja.2012.52. Epub 2012 Jun 27. Review.

PMID:
22739538
[PubMed - indexed for MEDLINE]
10.

Determining the mode of action of bioactive compounds.

Azad MA, Wright GD.

Bioorg Med Chem. 2012 Mar 15;20(6):1929-39. doi: 10.1016/j.bmc.2011.10.088. Epub 2012 Jan 17. Review.

PMID:
22300885
[PubMed - indexed for MEDLINE]
11.

Identifying druggable disease-modifying gene products.

Dixon SJ, Stockwell BR.

Curr Opin Chem Biol. 2009 Dec;13(5-6):549-55. doi: 10.1016/j.cbpa.2009.08.003. Epub 2009 Sep 7. Review.

PMID:
19740696
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A Synthetic Biology Project - Developing a single-molecule device for screening drug-target interactions.

Firman K, Evans L, Youell J.

FEBS Lett. 2012 Jul 16;586(15):2157-63. doi: 10.1016/j.febslet.2012.01.057. Epub 2012 Feb 8. Review.

PMID:
22710185
[PubMed - indexed for MEDLINE]
Free Article
13.

Regulation of both gene expression and protein stability provides genetically assisted target evaluation (GATE) for microbial target validation.

Buurman ET, Bradley JD, Donnelly CE, Moore JB, Healy JM, Averett DR, Thompson CM, Wobbe CR.

Pharmacogenomics. 2001 May;2(2):95-106. Review.

PMID:
11368749
[PubMed - indexed for MEDLINE]

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