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Results: 19

1.

Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.

Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J.

J Med Chem. 2011 Mar 10;54(5):1233-43. doi: 10.1021/jm1011929. Epub 2011 Feb 11.

PMID:
21314128
[PubMed - indexed for MEDLINE]
2.

Small-molecule inhibitors of the p53-MDM2 interaction.

Vu BT, Vassilev L.

Curr Top Microbiol Immunol. 2011;348:151-72. doi: 10.1007/82_2010_110. Review.

PMID:
21046355
[PubMed - indexed for MEDLINE]
3.

Inhibitors of MDM2 and MDMX: a structural perspective.

Riedinger C, McDonnell JM.

Future Med Chem. 2009 Sep;1(6):1075-94. doi: 10.4155/fmc.09.75. Review.

PMID:
21425995
[PubMed - indexed for MEDLINE]
4.

Molecular modeling approaches in the discovery of new drugs for anti-cancer therapy: the investigation of p53-MDM2 interaction and its inhibition by small molecules.

Lauria A, Tutone M, Ippolito M, Pantano L, Almerico AM.

Curr Med Chem. 2010;17(28):3142-54. Review.

PMID:
20666726
[PubMed - indexed for MEDLINE]
5.

Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface.

Chène P.

Mol Cancer Res. 2004 Jan;2(1):20-8. Review.

PMID:
14757842
[PubMed - indexed for MEDLINE]
Free Article
6.

Small molecule inhibitors of the p53-MDM2.

Hu CQ, Hu YZ.

Curr Med Chem. 2008;15(17):1720-30. Review.

PMID:
18673221
[PubMed - indexed for MEDLINE]
7.

Patented inhibitors of p53-Mdm2 interaction (2006 - 2008).

Weber L.

Expert Opin Ther Pat. 2010 Feb;20(2):179-91. doi: 10.1517/13543770903514129. Review.

PMID:
20100001
[PubMed - indexed for MEDLINE]
8.

Small molecule protein-protein inhibitors for the p53-MDM2 interaction.

Dudkina AS, Lindsley CW.

Curr Top Med Chem. 2007;7(10):952-60. Review.

PMID:
17508926
[PubMed - indexed for MEDLINE]
9.

MDM2 inhibitors for cancer therapy.

Vassilev LT.

Trends Mol Med. 2007 Jan;13(1):23-31. Epub 2006 Nov 28. Review.

PMID:
17126603
[PubMed - indexed for MEDLINE]
10.

Small molecule inhibitors of p53/MDM2 interaction.

Fotouhi N, Graves B.

Curr Top Med Chem. 2005;5(2):159-65. Review.

PMID:
15853644
[PubMed - indexed for MEDLINE]
11.

Small molecules targeting p53 to improve antitumor therapy.

Beretta GL, Gatti L, Benedetti V, Perego P, Zunino F.

Mini Rev Med Chem. 2008 Aug;8(9):856-68. Review.

PMID:
18691143
[PubMed - indexed for MEDLINE]
12.

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer.

Patel S, Player MR.

Expert Opin Investig Drugs. 2008 Dec;17(12):1865-82. doi: 10.1517/13543780802493366 . Review.

PMID:
19012502
[PubMed - indexed for MEDLINE]
13.

Small molecule antagonists of the MDM2 oncoprotein as anticancer agents.

Buolamwini JK, Addo J, Kamath S, Patil S, Mason D, Ores M.

Curr Cancer Drug Targets. 2005 Feb;5(1):57-68. Review.

PMID:
15720190
[PubMed - indexed for MEDLINE]
14.

Small-molecule inhibitors of p53-MDM2 interaction: the 2006-2010 update.

Millard M, Pathania D, Grande F, Xu S, Neamati N.

Curr Pharm Des. 2011;17(6):536-59. Review.

PMID:
21391905
[PubMed - indexed for MEDLINE]
15.

P53 mdm2 inhibitors.

Khoury K, Dömling A.

Curr Pharm Des. 2012;18(30):4668-78. Review.

PMID:
22650254
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction.

Clark RC, Lee SY, Searcey M, Boger DL.

Nat Prod Rep. 2009 Apr;26(4):465-77. Review.

PMID:
19642417
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Natural product MDM2 inhibitors: anticancer activity and mechanisms of action.

Qin JJ, Nag S, Voruganti S, Wang W, Zhang R.

Curr Med Chem. 2012;19(33):5705-25. Review.

PMID:
22830335
[PubMed - indexed for MEDLINE]
18.

Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present).

Zak K, Pecak A, Rys B, Wladyka B, Dömling A, Weber L, Holak TA, Dubin G.

Expert Opin Ther Pat. 2013 Apr;23(4):425-48. doi: 10.1517/13543776.2013.765405. Epub 2013 Feb 4. Review.

PMID:
23374098
[PubMed - indexed for MEDLINE]
19.

Imidazoline derivatives: a patent review (2006--present).

Guan X, Hu Y.

Expert Opin Ther Pat. 2012 Nov;22(11):1353-65. doi: 10.1517/13543776.2012.727397. Epub 2012 Sep 24. Review.

PMID:
23003008
[PubMed - indexed for MEDLINE]

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