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Results: 16

Related Articles by Review for PubMed (Select 21244642)

1.

Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.

Riedinger C, Noble ME, Wright DJ, Mulks F, Hardcastle IR, Endicott JA, McDonnell JM.

Chem Biol Drug Des. 2011 May;77(5):301-8. doi: 10.1111/j.1747-0285.2011.01091.x. Epub 2011 Mar 1.

PMID:
21244642
2.

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

Zhao Y, Aguilar A, Bernard D, Wang S.

J Med Chem. 2015 Feb 12;58(3):1038-52. doi: 10.1021/jm501092z. Epub 2014 Nov 14. Review.

PMID:
25396320
3.

Pharmacologic activation of p53 by small-molecule MDM2 antagonists.

Shen H, Maki CG.

Curr Pharm Des. 2011;17(6):560-8. Review.

4.

Small molecule protein-protein inhibitors for the p53-MDM2 interaction.

Dudkina AS, Lindsley CW.

Curr Top Med Chem. 2007;7(10):952-60. Review.

PMID:
17508926
5.

Small molecule inhibitors of the p53-MDM2.

Hu CQ, Hu YZ.

Curr Med Chem. 2008;15(17):1720-30. Review.

PMID:
18673221
6.

P53 mdm2 inhibitors.

Khoury K, Dömling A.

Curr Pharm Des. 2012;18(30):4668-78. Review.

7.

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.

Shangary S, Wang S.

Annu Rev Pharmacol Toxicol. 2009;49:223-41. doi: 10.1146/annurev.pharmtox.48.113006.094723. Review.

8.

Nutlins and ionizing radiation in cancer therapy.

Impicciatore G, Sancilio S, Miscia S, Di Pietro R.

Curr Pharm Des. 2010;16(12):1427-42. Review.

PMID:
20166982
9.

Inhibitors of MDM2 and MDMX: a structural perspective.

Riedinger C, McDonnell JM.

Future Med Chem. 2009 Sep;1(6):1075-94. doi: 10.4155/fmc.09.75. Review.

PMID:
21425995
10.

MDM2 non-genotoxic inhibitors as innovative therapeutic approaches for the treatment of pediatric malignancies.

Tisato V, Norcio A, Voltan R, Celeghini C, Zella D, Secchiero P.

Curr Med Chem. 2013;20(17):2226-36. Review.

PMID:
23458617
11.

Small-molecule inhibitors of the p53-MDM2 interaction.

Vu BT, Vassilev L.

Curr Top Microbiol Immunol. 2011;348:151-72. doi: 10.1007/82_2010_110. Review.

PMID:
21046355
12.

p53-Mdm2 inhibitors: patent review (2009 - 2010).

Kamal A, Mohammed AA, Shaik TB.

Expert Opin Ther Pat. 2012 Feb;22(2):95-105. doi: 10.1517/13543776.2012.656593. Epub 2012 Feb 9. Review.

PMID:
22316395
13.

Natural product MDM2 inhibitors: anticancer activity and mechanisms of action.

Qin JJ, Nag S, Voruganti S, Wang W, Zhang R.

Curr Med Chem. 2012;19(33):5705-25. Review.

PMID:
22830335
14.

The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological malignancies.

Secchiero P, di Iasio MG, Gonelli A, Zauli G.

Curr Pharm Des. 2008;14(21):2100-10. Review.

PMID:
18691119
15.

Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer.

Rew Y, Sun D.

J Med Chem. 2014 Aug 14;57(15):6332-41. doi: 10.1021/jm500627s. Epub 2014 Jul 9. Review.

PMID:
24967612
16.

[Role of p53 in leukemia].

Kojima K.

Rinsho Ketsueki. 2014 Oct;55(10):1724-30. Review. Japanese. No abstract available.

PMID:
25297733
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