Format

Send to

Choose Destination

Links from PubMed

See comment in PubMed Commons below
Opt Lett. 2010 Jul 1;35(13):2121-3. doi: 10.1364/OL.35.002121.

Time-resolved diffuse optical tomography with patterned-light illumination and detection.

Author information

  • 1Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

Abstract

This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures based on wide-field patterned-light strategies are feasible and outperform classical point excitation schemes for similar data set sizes. Moreover, we demonstrate that time-domain information is retained even though large spatial areas are illuminated. The enhanced time-domain data set allows for quantitative three-dimensional imaging in thick tissue based on relatively small data sets associated with much shorter acquisition times.

PMID:
20596166
PMCID:
PMC4638228
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Optical Society of America Icon for PubMed Central
    Loading ...
    Write to the Help Desk