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Results: 1 to 20 of 44

1.

An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Tian Y, Bassit B, Chau D, Li YM.

Nat Struct Mol Biol. 2010 Feb;17(2):151-8. doi: 10.1038/nsmb.1743. Epub 2010 Jan 10.

PMID:
20062056
[PubMed - indexed for MEDLINE]
2.

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.

Evin G, Sernee MF, Masters CL.

CNS Drugs. 2006;20(5):351-72. Review.

PMID:
16696577
[PubMed - indexed for MEDLINE]
3.

[Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease].

Tomita T.

Rinsho Shinkeigaku. 2008 Nov;48(11):907-9. Review. Japanese.

PMID:
19198114
[PubMed - indexed for MEDLINE]
4.

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J.

Physiol Behav. 2007 Sep 10;92(1-2):115-20. Epub 2007 May 21. Review.

PMID:
17588625
[PubMed - indexed for MEDLINE]
5.

Activity of gamma-secretase on substrates other than APP.

Lleó A.

Curr Top Med Chem. 2008;8(1):9-16. Review.

PMID:
18220928
[PubMed - indexed for MEDLINE]
6.

At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism.

Tomita T.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):295-300. Epub 2007 Nov 24. Review.

PMID:
18038124
[PubMed - indexed for MEDLINE]
7.

Secretase inhibitors and modulators for Alzheimer's disease treatment.

Tomita T.

Expert Rev Neurother. 2009 May;9(5):661-79. doi: 10.1586/ern.09.24. Review.

PMID:
19402777
[PubMed - indexed for MEDLINE]
8.

The search for gamma-secretase and development of inhibitors.

Tsai JY, Wolfe MS, Xia W.

Curr Med Chem. 2002 Jun;9(11):1087-106. Review.

PMID:
12052174
[PubMed - indexed for MEDLINE]
9.

The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

Stockley JH, O'Neill C.

Biochem Soc Trans. 2007 Jun;35(Pt 3):574-6. Review.

PMID:
17511655
[PubMed - indexed for MEDLINE]
10.

Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.

Pollack SJ, Lewis H.

Curr Opin Investig Drugs. 2005 Jan;6(1):35-47. Review.

PMID:
15675602
[PubMed - indexed for MEDLINE]
11.

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.

Wolfe MS.

Int Immunopharmacol. 2002 Dec;2(13-14):1919-29. Review.

PMID:
12489805
[PubMed - indexed for MEDLINE]
12.

The catalytic core of gamma-secretase: presenilin revisited.

Steiner H.

Curr Alzheimer Res. 2008 Apr;5(2):147-57. Review.

PMID:
18393799
[PubMed - indexed for MEDLINE]
13.

gamma-Secretase as a therapeutic target in Alzheimer's disease.

Guardia-Laguarta C, Pera M, Lleó A.

Curr Drug Targets. 2010 Apr;11(4):506-17. Review.

PMID:
20015011
[PubMed - indexed for MEDLINE]
14.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
[PubMed - indexed for MEDLINE]
15.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
[PubMed - indexed for MEDLINE]
16.

Regulation of APP cleavage by alpha-, beta- and gamma-secretases.

Nunan J, Small DH.

FEBS Lett. 2000 Oct 13;483(1):6-10. Review.

PMID:
11033346
[PubMed - indexed for MEDLINE]
Free Article
17.

[Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity].

Tomita T.

Rinsho Shinkeigaku. 2009 Nov;49(11):845-7. Review. Japanese.

PMID:
20030227
[PubMed - indexed for MEDLINE]
18.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
[PubMed - indexed for MEDLINE]
19.

Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?

Nawrot B.

Acta Biochim Pol. 2004;51(2):431-44. Review.

PMID:
15218540
[PubMed - indexed for MEDLINE]
Free Article
20.

gamma-Secretase inhibitors as molecular probes of presenilin function.

Wolfe MS.

J Mol Neurosci. 2001 Oct;17(2):199-204. Review.

PMID:
11816793
[PubMed - indexed for MEDLINE]
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