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Items: 1 to 20 of 23

1.

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins.

Schrank TP, Bolen DW, Hilser VJ.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16984-9. doi: 10.1073/pnas.0906510106. Epub 2009 Sep 21.

2.

Conformational heterogeneity within the LID domain mediates substrate binding to Escherichia coli adenylate kinase: function follows fluctuations.

Schrank TP, Wrabl JO, Hilser VJ.

Top Curr Chem. 2013;337:95-121. doi: 10.1007/128_2012_410. Review.

PMID:
23543318
3.

Folding funnels and conformational transitions via hinge-bending motions.

Kumar S, Ma B, Tsai CJ, Wolfson H, Nussinov R.

Cell Biochem Biophys. 1999;31(2):141-64. Review.

PMID:
10593256
4.

The role of protein conformational fluctuations in allostery, function, and evolution.

Wrabl JO, Gu J, Liu T, Schrank TP, Whitten ST, Hilser VJ.

Biophys Chem. 2011 Nov;159(1):129-41. doi: 10.1016/j.bpc.2011.05.020. Epub 2011 May 31. Review.

PMID:
21684672
5.

The origin of allosteric functional modulation: multiple pre-existing pathways.

del Sol A, Tsai CJ, Ma B, Nussinov R.

Structure. 2009 Aug 12;17(8):1042-50. doi: 10.1016/j.str.2009.06.008. Review.

6.

Fluctuations within folded proteins: implications for thermodynamic and allosteric regulation.

DuBay KH, Bowman GR, Geissler PL.

Acc Chem Res. 2015 Apr 21;48(4):1098-105. doi: 10.1021/ar500351b. Epub 2015 Feb 17. Review.

PMID:
25688669
7.

Protein dynamics and allostery: an NMR view.

Tzeng SR, Kalodimos CG.

Curr Opin Struct Biol. 2011 Feb;21(1):62-7. doi: 10.1016/j.sbi.2010.10.007. Epub 2010 Nov 23. Review.

PMID:
21109422
8.

The ensemble nature of allostery.

Motlagh HN, Wrabl JO, Li J, Hilser VJ.

Nature. 2014 Apr 17;508(7496):331-9. doi: 10.1038/nature13001. Review.

9.

Allostery in pharmacology: thermodynamics, evolution and design.

Maksay G.

Prog Biophys Mol Biol. 2011 Sep;106(3):463-73. doi: 10.1016/j.pbiomolbio.2011.01.001. Epub 2011 Jan 9. Review.

PMID:
21223978
10.

Modulation of allostery of pyruvate kinase by shifting of an ensemble of microstates.

Lee JC.

Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):663-9. Review.

11.

Emerging computational approaches for the study of protein allostery.

Collier G, Ortiz V.

Arch Biochem Biophys. 2013 Oct 1;538(1):6-15. doi: 10.1016/j.abb.2013.07.025. Epub 2013 Aug 8. Review.

PMID:
23933229
12.

Elements and modulation of functional dynamics.

Gibbs AC.

J Med Chem. 2014 Oct 9;57(19):7819-37. doi: 10.1021/jm500325k. Epub 2014 Jun 10. Review.

PMID:
24913411
13.

Physicochemical bases for protein folding, dynamics, and protein-ligand binding.

Li H, Xie Y, Liu C, Liu S.

Sci China Life Sci. 2014 Mar;57(3):287-302. doi: 10.1007/s11427-014-4617-2. Epub 2014 Feb 19. Review.

PMID:
24554472
14.

Seeing the forest for the trees: fluorescence studies of single enzymes in the context of ensemble experiments.

Tan YW, Yang H.

Phys Chem Chem Phys. 2011 Feb 7;13(5):1709-21. doi: 10.1039/c0cp02412k. Epub 2010 Dec 23. Review.

PMID:
21183988
15.

Dynamic allostery: linkers are not merely flexible.

Ma B, Tsai CJ, Haliloğlu T, Nussinov R.

Structure. 2011 Jul 13;19(7):907-17. doi: 10.1016/j.str.2011.06.002. Review.

16.

Protein mechanics: how force regulates molecular function.

Seifert C, Gräter F.

Biochim Biophys Acta. 2013 Oct;1830(10):4762-8. doi: 10.1016/j.bbagen.2013.06.005. Epub 2013 Jun 19. Review.

PMID:
23791949
17.

Allostery in disease and in drug discovery.

Nussinov R, Tsai CJ.

Cell. 2013 Apr 11;153(2):293-305. doi: 10.1016/j.cell.2013.03.034. Review.

18.

Allostery and population shift in drug discovery.

Kar G, Keskin O, Gursoy A, Nussinov R.

Curr Opin Pharmacol. 2010 Dec;10(6):715-22. doi: 10.1016/j.coph.2010.09.002. Epub 2010 Sep 29. Review.

PMID:
20884293
19.

Adaptability in protein structures: structural dynamics and implications in ligand design.

Maity A, Majumdar S, Priya P, De P, Saha S, Ghosh Dastidar S.

J Biomol Struct Dyn. 2015;33(2):298-321. doi: 10.1080/07391102.2013.873002. Epub 2014 Jan 16. Review.

PMID:
24433438
20.

Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation.

Bahar I, Chennubhotla C, Tobi D.

Curr Opin Struct Biol. 2007 Dec;17(6):633-40. Epub 2007 Nov 19. Review.

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