Send to:

Choose Destination

Related Articles by Review for PubMed (Select 19296215)

See comment in PubMed Commons below
Breast Cancer Res Treat. 2009 Dec;118(3):575-81. doi: 10.1007/s10549-009-0368-3. Epub 2009 Mar 19.

No evidence of familial correlation in breast cancer metastasis.

Author information

  • 1Department of Health Research and Policy, Stanford University School of Medicine, Redwood Building, Room T204, Stanford, CA, 94305-5405, USA.


Animal experiments support the hypothesis that the metastatic potential of breast cancer is a heritable trait of the host. Our objective was to evaluate correlations in metastasis occurrence in large families with multiple cases of breast cancer. We evaluated correlation among pairs of relatives in the occurrence and timing of distant metastasis using retrospective cohort data from 743 female breast cancer patients in 242 families. We adjusted for correlation in their age at diagnosis, year of diagnosis, educational level, lymph node involvement, and estrogen receptor status. Distant metastasis occurred in 255 patients (34.3%) during mean followup of 11.7 years. None of the correlation coefficients for metastasis in blood relatives differed significantly from zero. The estimated correlation coefficient in first-degree relatives was -0.03 (95% confidence interval -0.11 to 0.06). These findings suggest that a family history of metastatic breast cancer does not contribute substantially to risk of metastasis for breast cancer patients.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk