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Results: 17

1.

Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.

Yang G, Yin YI, Chun J, Shelton CC, Ouerfelli O, Li YM.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):922-5. doi: 10.1016/j.bmcl.2008.11.117. Epub 2008 Dec 7.

PMID:
19097779
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Assembly of the presenilin γ-/ε-secretase complex.

St George-Hyslop P, Fraser PE.

J Neurochem. 2012 Jan;120 Suppl 1:84-8. doi: 10.1111/j.1471-4159.2011.07505.x. Epub 2011 Nov 28. Review.

PMID:
22122073
[PubMed - indexed for MEDLINE]
3.

Recent progress in the medicinal chemistry of gamma-secretase inhibitors.

Olson RE, Albright CF.

Curr Top Med Chem. 2008;8(1):17-33. Review.

PMID:
18220929
[PubMed - indexed for MEDLINE]
4.

Secretase as a target for Alzheimer's disease.

Wolfe MS.

Curr Top Med Chem. 2002 Apr;2(4):371-83. Review.

PMID:
11966461
[PubMed - indexed for MEDLINE]
5.

Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.

D'Onofrio G, Panza F, Frisardi V, Solfrizzi V, Imbimbo BP, Paroni G, Cascavilla L, Seripa D, Pilotto A.

Expert Opin Drug Discov. 2012 Jan;7(1):19-37. doi: 10.1517/17460441.2012.645534. Epub 2011 Dec 14. Review.

PMID:
22468891
[PubMed - indexed for MEDLINE]
6.

[Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease].

Tomita T.

Rinsho Shinkeigaku. 2008 Nov;48(11):907-9. Review. Japanese.

PMID:
19198114
[PubMed - indexed for MEDLINE]
7.

A fast growing spectrum of biological functions of γ-secretase in development and disease.

Jurisch-Yaksi N, Sannerud R, Annaert W.

Biochim Biophys Acta. 2013 Dec;1828(12):2815-27. doi: 10.1016/j.bbamem.2013.04.016. Review.

PMID:
24099003
[PubMed - indexed for MEDLINE]
Free Article
8.

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.

Evin G, Sernee MF, Masters CL.

CNS Drugs. 2006;20(5):351-72. Review.

PMID:
16696577
[PubMed - indexed for MEDLINE]
9.

gamma-Secretase as a therapeutic target in Alzheimer's disease.

Guardia-Laguarta C, Pera M, Lleó A.

Curr Drug Targets. 2010 Apr;11(4):506-17. Review.

PMID:
20015011
[PubMed - indexed for MEDLINE]
10.

Secretase inhibitors and modulators for Alzheimer's disease treatment.

Tomita T.

Expert Rev Neurother. 2009 May;9(5):661-79. doi: 10.1586/ern.09.24. Review.

PMID:
19402777
[PubMed - indexed for MEDLINE]
11.

Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation.

Panza F, Frisardi V, Solfrizzi V, Imbimbo BP, Logroscino G, Santamato A, Greco A, Seripa D, Pilotto A.

Curr Med Chem. 2011;18(35):5430-47. Review.

PMID:
22087836
[PubMed - indexed for MEDLINE]
12.

gamma-Secretase inhibitors as molecular probes of presenilin function.

Wolfe MS.

J Mol Neurosci. 2001 Oct;17(2):199-204. Review.

PMID:
11816793
[PubMed - indexed for MEDLINE]
13.

Relationship between presenilinase and gamma-secretase.

Xia W.

Drug News Perspect. 2003 Mar;16(2):69-74. Review.

PMID:
12792666
[PubMed - indexed for MEDLINE]
14.

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J.

Physiol Behav. 2007 Sep 10;92(1-2):115-20. Epub 2007 May 21. Review.

PMID:
17588625
[PubMed - indexed for MEDLINE]
15.

Presenilin: running with scissors in the membrane.

Selkoe DJ, Wolfe MS.

Cell. 2007 Oct 19;131(2):215-21. Review.

PMID:
17956719
[PubMed - indexed for MEDLINE]
Free Article
16.

Gamma-secretase: a complex target for Alzheimer's disease.

Lundkvist J, Näslund J.

Curr Opin Pharmacol. 2007 Feb;7(1):112-8. Epub 2006 Dec 13. Review.

PMID:
17169612
[PubMed - indexed for MEDLINE]
17.

The structure and function of Alzheimer's gamma secretase enzyme complex.

Krishnaswamy S, Verdile G, Groth D, Kanyenda L, Martins RN.

Crit Rev Clin Lab Sci. 2009;46(5-6):282-301. doi: 10.3109/10408360903335821. Review.

PMID:
19958215
[PubMed - indexed for MEDLINE]

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