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Items: 1 to 20 of 21

1.

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C.

J Biol Chem. 2008 Oct 31;283(44):30121-8. doi: 10.1074/jbc.M806092200. Epub 2008 Sep 3.

2.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
3.

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

Fluhrer R, Haass C.

Neurodegener Dis. 2007;4(2-3):112-6. Review.

PMID:
17596705
4.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
5.

Intramembrane proteolysis by presenilin and presenilin-like proteases.

Xia W, Wolfe MS.

J Cell Sci. 2003 Jul 15;116(Pt 14):2839-44. Review.

6.

The catalytic core of gamma-secretase: presenilin revisited.

Steiner H.

Curr Alzheimer Res. 2008 Apr;5(2):147-57. Review.

PMID:
18393799
7.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
8.

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.

Fluhrer R, Steiner H, Haass C.

J Biol Chem. 2009 May 22;284(21):13975-9. doi: 10.1074/jbc.R800040200. Epub 2009 Feb 3. Review.

9.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
10.

Intramembrane proteolysis by gamma-secretase.

Steiner H, Fluhrer R, Haass C.

J Biol Chem. 2008 Oct 31;283(44):29627-31. doi: 10.1074/jbc.R800010200. Epub 2008 Jul 23. Review.

11.

The function of presenilin-1 in amyloid beta-peptide generation and brain development.

Saftig P, Hartmann D, De Strooper B.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):271-9. Review.

PMID:
10653282
12.

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.

Voss M, Schröder B, Fluhrer R.

Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033. Review.

13.

Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides.

Evin G, Weidemann A.

Peptides. 2002 Jul;23(7):1285-97. Review.

PMID:
12128085
14.

Cellular functions of gamma-secretase-related proteins.

Haffner C, Haass C.

Neurodegener Dis. 2006;3(4-5):284-9. Review.

PMID:
17047369
15.

Structural biology of presenilins and signal peptide peptidases.

Tomita T, Iwatsubo T.

J Biol Chem. 2013 May 24;288(21):14673-80. doi: 10.1074/jbc.R113.463281. Epub 2013 Apr 12. Review.

17.

Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.

Golde TE, Wolfe MS, Greenbaum DC.

Semin Cell Dev Biol. 2009 Apr;20(2):225-30. doi: 10.1016/j.semcdb.2009.02.003. Epub 2009 Feb 13. Review.

PMID:
19429495
18.

Molecular mechanism of intramembrane proteolysis by γ-secretase.

Tomita T.

J Biochem. 2014 Oct;156(4):195-201. doi: 10.1093/jb/mvu049. Epub 2014 Aug 9. Review.

PMID:
25108625
19.

Sequence analyses of presenilin mutations linked to familial Alzheimer's disease.

Kim SD, Kim J.

Cell Stress Chaperones. 2008 Dec;13(4):401-12. doi: 10.1007/s12192-008-0046-0. Epub 2008 May 20. Review.

20.

Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.

Strisovsky K.

FEBS J. 2013 Apr;280(7):1579-603. doi: 10.1111/febs.12199. Epub 2013 Mar 20. Review.

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